Anybody tried ursolic acid for CRC?

tachilders
tachilders Member Posts: 313
in Colorectal Cancer #1
A friend of mine's dad is a senior researcher at Mayo, and he recommended I look into ursolic acid for my colon cancer. I googled and found several scientific articles where they showed good anti-colon cancer activity in human cancer cells (in vitro) and in animal models for colon cancer. Ursolic acid is found in some plants/fruits like apple peels, cranberries, sage, etc... There is a company in Missouri that cells tablets. It has also shown anti-cancer activity against cervical cancer, prostate cancer, and a few others. Thanks for any help you can provide.

Tedd

Comments

  • janie1
    janie1 Member Posts: 753 Member
    #2
    Thanks for the info,
    Thanks for the info, Tedd.
    Haven't tried it, but like to read about anything with potential benefits.
    Hope you are doing well.
  • janie1
    janie1 Member Posts: 753 Member
    #3
    janie1 said:

    Thanks for the info,
    Thanks for the info, Tedd.
    Haven't tried it, but like to read about anything with potential benefits.
    Hope you are doing well.

    Hey Tedd.......me
    Hey Tedd.......me again.
    Just curious if your friend's dad recommended taking a tablet, or just eating a good variety of food that contains it.
    Sometimes you can't get enough of a substance through food alone. Can't see where a supplement of this would do any harm.
    Also, there was a fairly recent thread on this. Urosilic (sp?) acid was studied at MD Anderson. The results were the same as what your friend's dad said. Also, anyone on the oral chemo, Xeloda, the research said it "enhanced" the effectiveness of Xeloda when the urosilic acid was given. Don't have a clue as to the dosage they were talking about......that could be a big difference.
    Did your friend's dad say anything about a dosage (or does he know?) if taking a supplement? Might want to ask him that.
    The reason I ask these things, are because if there is something so easy that could be done to help ourselves, then I say "go for it".
    I don't take any supplements on the days that chemo is in my body.....i don't want to mess up anything with the chemo, but on the "off" days...i like to take what makes sense.
    Thanks again.
  • tachilders
    tachilders Member Posts: 313
    #4
    janie1 said:

    Hey Tedd.......me
    Hey Tedd.......me again.
    Just curious if your friend's dad recommended taking a tablet, or just eating a good variety of food that contains it.
    Sometimes you can't get enough of a substance through food alone. Can't see where a supplement of this would do any harm.
    Also, there was a fairly recent thread on this. Urosilic (sp?) acid was studied at MD Anderson. The results were the same as what your friend's dad said. Also, anyone on the oral chemo, Xeloda, the research said it "enhanced" the effectiveness of Xeloda when the urosilic acid was given. Don't have a clue as to the dosage they were talking about......that could be a big difference.
    Did your friend's dad say anything about a dosage (or does he know?) if taking a supplement? Might want to ask him that.
    The reason I ask these things, are because if there is something so easy that could be done to help ourselves, then I say "go for it".
    I don't take any supplements on the days that chemo is in my body.....i don't want to mess up anything with the chemo, but on the "off" days...i like to take what makes sense.
    Thanks again.

    Not too much to add...
    ... but my friend's dad just indicated a place to get the tablets. The dose appears to be 150 mg/day (3 tablets), and a month's supply is $80. The company he indicated is Essence of Life in Missouri. There may be other suppliers of it, but I haven't done extensive research on that. I was also thinking of taking it on my chemo off-week. Not sure how much is in the various plants that contain it, but it can't hurt to eat more apples or cranberries.

    Tedd
  • tachilders
    tachilders Member Posts: 313
    #5
    tachilders said:

    Not too much to add...
    ... but my friend's dad just indicated a place to get the tablets. The dose appears to be 150 mg/day (3 tablets), and a month's supply is $80. The company he indicated is Essence of Life in Missouri. There may be other suppliers of it, but I haven't done extensive research on that. I was also thinking of taking it on my chemo off-week. Not sure how much is in the various plants that contain it, but it can't hurt to eat more apples or cranberries.

    Tedd

    Did some googling
    Only recommendation of dosing that I could find was 1.6 mg/kg for humans, based on a conversion from a rat dose. That means that 156 mg (the daily dose from Essence of Life tablets) would be appropriate for a 100 kg (220 lb) person. The good news is that UA demonstrates good activity at really low doses in mice, so 1.6 mg/kg might be even higher than needed. I would think 2 tablets a day would be enough for most people, but that's just a guess. I couldn't find any info on how much UA would be in a single apple peel.

    Tedd
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #6
    thanks for reminding me tedd
    look at the discussion a few months back.

    http://csn.cancer.org/node/244354

    we talked about this a while ago.

    good luck with it, the prunes and the cranberies and apple skins are my sources.

    hugs,
    Pete
  • smokeyjoe
    smokeyjoe Member Posts: 1,425 Member
    #7
    pete43lost_at_sea said:

    thanks for reminding me tedd
    look at the discussion a few months back.

    http://csn.cancer.org/node/244354

    we talked about this a while ago.

    good luck with it, the prunes and the cranberies and apple skins are my sources.

    hugs,
    Pete

    Apparently the rind of
    Apparently the rind of watermelons is high in ursolic acid....weird... the part we don't eat and toss away!!!

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