Scan results (round 7 on Folfiri + Cetuximab)

spainmum

Hi to all,

A Couple of weeks ago my mom had the results of the CT after round 7 of the comparison arm of a clinical trial.

For those that haven't read my old post about my mom, this is her journey: dx on October 2011 at that moment she had a primary on the sigmoid and another primary on the cecum and multiple mets on Liver, Lungs, Peritoneum and retroperitoneum, she wasn't candidate for surgery. The two biggest of the Liver were 57 mm and 38 mm and the biggest of the Lungs were 21 mm and the CEA was 317, then she had 6 rounds of Folfox that didn't work and then enter on this trial, now the results for the moment are that CEA goes of 143 at the start of the trial to 33 now, the big one of the Liver goes from 56 mm to 44 and the another big one of the liver from 43 mm to 41 and the two biggest of the Lungs goes from 24 mm to 21 and from 24 mm to 25 mm, although this is not bad the onc said that one day this chemo will not work and then we will have to found another trial of a drug on phase I. Since hearing this I had the hope that one day she could be candidate to surgery, but now I don't now what to expect.


Celeste.

pepebcn

Hi Celeste this are good news!
There are other options beside Folfox, like folfiri and the new regoranfenib and afilbercept, with not needing of a new trial!
Did they offered any of them?
Hug my friend!

spainmum

pepebcn said:

Hi Celeste this are good news!
There are other options beside Folfox, like folfiri and the new regoranfenib and afilbercept, with not needing of a new trial!
Did they offered any of them?
Hug my friend!

Hi Pepe
She said regoranfenib only is in a trial that my mom don't acomplish the conditions to enter and that as Folfox didn't work in the past then when Folfiri stop working then they won't have any other chemo. They said this before the aproval of afilbercept but I had read that this is a drug to combined with Folfiri. They don't want to give her avastin because they may have to do a surgery for obstruction.

Hugs Pepe.

pepebcn

spainmum said:

Hi Pepe
She said regoranfenib only is in a trial that my mom don't acomplish the conditions to enter and that as Folfox didn't work in the past then when Folfiri stop working then they won't have any other chemo. They said this before the aproval of afilbercept but I had read that this is a drug to combined with Folfiri. They don't want to give her avastin because they may have to do a surgery for obstruction.

Hugs Pepe.

I would insist in Regoranfenib ! Many hospitals are giving it
In open trial so nothing requested for it , which hospital is mum? Concerning to alfibercept ,yes is mixed with Folfiri but the combo can work even with old drugs that you have tried before and tha they stop it's effectivity! that's the trick on this new medicines !
Hugs!

peterz54

FDA Approves Aflibercept
FDA Approves Aflibercept

June status for Regorafenib
Regorafenib status
My wife is similar to your mother in terms of the spread of cancer yet her Onc mentioned going on Regorafenib. Maybe you could ask for details as to why your mother's onc thinks otherwise for her.

but be aware that, despite the hype, these drugs only add weeks (roughly 6), to the average patient's life. much the same as each of the drugs which have been added since the days of 5FU only.

Some studies suggest that staying on avastin beyond progression adds more time, yet it is not clear to me that this is standard practice.

your mother appears to be K-RAS wild type and so can take EGFR inhibitors, which is a good thing.

spainmum

pepebcn said:

I would insist in Regoranfenib ! Many hospitals are giving it
In open trial so nothing requested for it , which hospital is mum? Concerning to alfibercept ,yes is mixed with Folfiri but the combo can work even with old drugs that you have tried before and tha they stop it's effectivity! that's the trick on this new medicines !
Hugs!

Thanks
Thanks Pepe,

I'm finding solutions for when this combo stop working. The hospital were are treating my mom is the "Institut Català d'Oncologia" but the onc said when this happens she will be derived to Vall d'Hebron. I hope when this happens the Regoranfenib will be approved.

Hugs.

spainmum

peterz54 said:

FDA Approves Aflibercept
FDA Approves Aflibercept

June status for Regorafenib
Regorafenib status
My wife is similar to your mother in terms of the spread of cancer yet her Onc mentioned going on Regorafenib. Maybe you could ask for details as to why your mother's onc thinks otherwise for her.

but be aware that, despite the hype, these drugs only add weeks (roughly 6), to the average patient's life. much the same as each of the drugs which have been added since the days of 5FU only.

Some studies suggest that staying on avastin beyond progression adds more time, yet it is not clear to me that this is standard practice.

your mother appears to be K-RAS wild type and so can take EGFR inhibitors, which is a good thing.

Thanks for the information
Thanks Peter for the information, yes I know that all this drugs only adds time, but I have the hope the tumors could shrink enough to be a candidate for surgery.

About the Kras type, the primary tumor is mutated, but for entering on this trial they made a biopsy of the liver and found that this met is wild type and for this reason she is on Cetuximab.

Hugs and hoping Rogarafenib works good for your wife.

peterz54

spainmum said:

Thanks for the information
Thanks Peter for the information, yes I know that all this drugs only adds time, but I have the hope the tumors could shrink enough to be a candidate for surgery.

About the Kras type, the primary tumor is mutated, but for entering on this trial they made a biopsy of the liver and found that this met is wild type and for this reason she is on Cetuximab.

Hugs and hoping Rogarafenib works good for your wife.

Celeste, I will have to
Celeste, I will have to check into the issue of liver vs primary KRAS and use of EGFR inhibitors. was not aware this might be an option. My wife's primary is K-mut and she has significant liver mets.

spainmum

peterz54 said:

Celeste, I will have to
Celeste, I will have to check into the issue of liver vs primary KRAS and use of EGFR inhibitors. was not aware this might be an option. My wife's primary is K-mut and she has significant liver mets.

Yes,
Yes, I was surprised when they give us the results and put her in the arm of Erbitux, I think we were lucky entering in this trial because she don't get the new drug(GA201), but has the opportunity of being in Erbitux, that seems to be working in one of the liver tumors.