Answer me this.....

Timlong

Is "Advanced Prostate Cancer" determined by the Gleason score or is the term used
if and when mets occurs?

Jeff

Kongo

It depends
Jeff,

Good question and I think there are many answers. There can be locally advanced which is usually characterized by stage and Gleason score as well as "metastatic cancer" where there are mets involved. Both are "advanced." Some suggest that an expanded definition is needed.

See this article on the evolving definition of advanced prostate cancer

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472896/?tool=pubmed

This is another useful definition document:

http://www.ncbi.nlm.nih.gov/pubmed/17845994