I have been on Sutent for 6 months. I take 37.5 mg for two weeks and then I am off one week. I have been on some type of blood pressure medicine for the past 30 years. I have been taking Toprol 50 mg and Norvasc 5 mg since my surgery (complete nephrectomy of right kidney in July 2011) and my blood pressure has been perfect. Over the last week, I noted that my pressure was up significantly (160/96) and my oncologist recommended I call my internist who has been working with my pressures for the last 20 years. My internist doubled my dose of Norvasc, but I have seen no improvement. Anyone else have this issue? I need to know if anyone has had to stop taking Sutent due to blood pressure. That would really bum me out, since Sutent seems to really be working for me (regression and resolution of mets in the lungs). Next scan is next week and hoping for more good results.