CureToday.com article

allmost60
allmost60 Member Posts: 3,178 Member
in Lymphoma (Hodgkin and Non-Hodgkin) #1
Hi Guys,
Just thought I would share this info with you. I get newsletters from CureToday and this was in my e-mail today. Hope everyone is doing good. We are expecting snow today, so I'm getting hunkered down in case it turns out to be more snow than whats being predicted.BRRRRR!
Love...Sue (FNHL-2-3A-6/10)

CuereToday.com
BY ELIZABETH WHITTINGTON
PUBLISHED JANUARY 5, 2012

GA101, an investigational cancer therapy that targets the CD20 receptor found on non-Hodgkin lymphoma cells, could be the next step for patients who relapse on Rituxan (rituximab), a current standard of therapy.

Rituxan also targets the CD20 receptor and uses the body’s immune system to attack cancerous cells. This monoclonal antibody has been around for about a decade and treats several types of non-Hodgkin lymphoma and certain other lymphoid malignancies. “There is a real motivation to take it one step further and create a new [drug] that might work better or to use once Rituxan stops working,” said Laurie H. Sehn, MD, MPH, who headed up the phase 2 study.

Scientists compared GA101, also called obinutuzumab, with Rituxan and found the novel agent improved response rates. Patients with relapsed NHL received either drug for four weekly injections (called induction therapy) and then as maintenance therapy for two years. After two years follow-up, complete remission rates more than doubled from 5.3 percent in the Rituxan arm to 12.2 percent in the GA101 arm. Patients receiving GA101 had a higher risk of infusion reaction, but had fewer severe reactions compared with patients receiving Rituxan. A phase 3 trial is currently under way.

Additional studies are looking at combining GA101 with chemotherapy and testing the drug in both newly diagnosed and relapsed advanced follicular lymphoma as well as newly diagnosed chronic lymphocytic leukemia.

Comments

  • miss maggie
    miss maggie Member Posts: 929
    #2
    Thank you
    Dear Sue,

    Thank you so very much for posting the latest news for indolent NHL.

    Right now I am in remission as of Jan 2011. My DX as of Jan 2009 is Marginal B cell lymphoma,
    stage 1, low grade of the small bowel. I suppose it is a form of indolent NHL.
    My oncologist informed me it might return in 5 years or so. Maybe sooner. If it
    did return, she would treat me with Rituxan only. Maybe if the NHL returns, I might have another option.

    You are so sweet posting your research, thanks again. Love you still. How is the baby?

    Love Maggie
  • COBRA666
    COBRA666 Member Posts: 2,401 Member
    #3
    A New Drug
    Sue,
    So glad you posted the article about the newer drug for lymphoma. It gives the people here even more hope if a relapse should happen.It has been a slow week thus far on the board,but I am sure as time goes on most will click on and read the latest article. John(FNHL-1-4A-5/10)
  • allmost60
    allmost60 Member Posts: 3,178 Member
    #4
    miss maggie said:

    Thank you
    Dear Sue,

    Thank you so very much for posting the latest news for indolent NHL.

    Right now I am in remission as of Jan 2011. My DX as of Jan 2009 is Marginal B cell lymphoma,
    stage 1, low grade of the small bowel. I suppose it is a form of indolent NHL.
    My oncologist informed me it might return in 5 years or so. Maybe sooner. If it
    did return, she would treat me with Rituxan only. Maybe if the NHL returns, I might have another option.

    You are so sweet posting your research, thanks again. Love you still. How is the baby?

    Love Maggie

    Your welcome...
    Hi John and Maggie,
    I'm glad you read the article and yes...it does give us hope for another option if we have a recurrance. We must never give up hope! Lizzy is doing fine Maggie and thanks for asking. she's growing like a weed! She rolls all over the house as she hasn't quite mastered crawling yet. She's a chunk weighing in at 27 pounds. She's 9 mo's old and doing so many funny things that keep me laughing all day long. We woke up to a bunch of snow this morning, so she doesn't know what to make of it. Next year I'll have her outside playing it...can't wait!!! Hope you both have a great day...looks like I'll be house bound until the snow lets up. They say a possibility of 15 inches..YIKES!..ha! Oh well...thats what happens when you live in the Pacific Northwest, and we love our 4 seasons...snow included!
    Take care...Love ya...Sue (FNHL-2-3A-6/10)
  • trustinJesus
    trustinJesus Member Posts: 59
    #5
    COBRA666 said:

    A New Drug
    Sue,
    So glad you posted the article about the newer drug for lymphoma. It gives the people here even more hope if a relapse should happen.It has been a slow week thus far on the board,but I am sure as time goes on most will click on and read the latest article. John(FNHL-1-4A-5/10)

    Thanks
    Thanks for the info. I passed it on to my dad.
  • onlytoday
    onlytoday Member Posts: 609 Member
    #6
    Obinutuzumab
    Hi,

    My oncologist had mentioned this to me last year as a possibility down the road.I guess it's not quite approved yet but it sounds exciting! Thanks for sharing this with everyone. I know that the trials are going on and lots of research is happening behind the scenes but I wish it would all happen sooner rather than later. :)

    Donna
  • Rose46
    Rose46 Member Posts: 1
    #7
    curetoday.com article
    Thanks much for the info. I have been living with SLL since 2007. Just recently had CT scan that shows progression of the cancer after 4 plus years of good scans following chemo. I am bummed out at this point. Will find out plan of attack next week when I see my oncologist to discuss. I just joined this site today, so thank you very much for being there.
  • allmost60
    allmost60 Member Posts: 3,178 Member
    #8
    Rose46 said:

    curetoday.com article
    Thanks much for the info. I have been living with SLL since 2007. Just recently had CT scan that shows progression of the cancer after 4 plus years of good scans following chemo. I am bummed out at this point. Will find out plan of attack next week when I see my oncologist to discuss. I just joined this site today, so thank you very much for being there.

    Welcome Rose46
    Hi Rose,
    Welcome to our group. I'm so sorry your cancer has started to progress. Getting 4 years of clean scans and then to have it start acting up again, is definetely a bummer. One bright spot in all of this is that new treatments seem to be looking promising for management when we do have a recurrance. I hope next week your Onc will have a good plan to put your cancer back in check again. Stick with the group and we can help you through whatever you may have facing you. There's a whole group of us waiting and wondering when we may have to go through the same thing as you...we certainly understand and will be here for you. Let us know what you find out. Best wishes...Sue
    (Follicular NHL-stage3-grade2-typeA-diagnosed June 2010) age 60.
  • COBRA666
    COBRA666 Member Posts: 2,401 Member
    #9
    Rose46 said:

    curetoday.com article
    Thanks much for the info. I have been living with SLL since 2007. Just recently had CT scan that shows progression of the cancer after 4 plus years of good scans following chemo. I am bummed out at this point. Will find out plan of attack next week when I see my oncologist to discuss. I just joined this site today, so thank you very much for being there.

    Hi Rose
    I am one of those waiting and wondering if or when mine will return as well. Hell of a way to live ain't it? Like Sue said there are newer ways they have to keep this stuff in check. It looks like from way it is going they are not far from either letting the cure out OR suppressing the progression for years and years. John (FNHL-4-1A-5/10)
  • regans
    regans Member Posts: 2
    #10
    GA101
    Does this work on CD20 Negative?

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