Celebrex-adhesions

smokeyjoe

Adhesions - bands of scar tissue that bind together two internal body surfaces - develop in 55 percent to more than 90 percent of patients undergoing surgery, depending on the type of operation. They are part of normal healing, but when surfaces fuse together that shouldn't, serious pain and complications can result. Adhesions are a major cause of bowel obstruction and infertility, and repeat surgery is often needed to cut through them. Unfortunately, adhesions often recur after these surgeries, and there has been no good way of preventing them.

Investigations led by Dr. Mark Puder and Dr. Arin Greene in the Department of Surgery and the Vascular Biology Program at Children's Hospital Boston tested COX-2 inhibitors in an animal model of abdominal adhesion formation. After undergoing surgery, groups of 6 to 18 mice received either COX-2 inhibitors (Celebrex or Vioxx), non-selective COX inhibitors (such as ibuprofen and aspirin) or placebo for 10 days.

"Results were dramatic," says Puder, senior investigator on the study.

At 10 days, the placebo group had obvious abdominal adhesions. Mice receiving non-selective COX inhibitors had a slight reduction in adhesions, and the COX-2 inhibitor group had a larger reduction. The greatest reduction was in the mice given Celebrex, and 6 of 11 Celebrex-treated mice (55%) were completely adhesion-free.

pete43lost_at_sea

interesting research
just an fyi i heard from a pharmacist i trust, that celebrex might be black boxed, thats terminalogy for it being withdrawn. so just keep this warning in the back of your mind, i would ask my doctor before going on it. possibly the benefits may out weigh the possible negatives. the joys , the uncertainties of crc.
hugs,
pete

John23

Vioxx etc...

My wife suffered a ruptured cerebral aneurysm (2, actually)
as a direct result of taking VIOXX (It erodes the inside of
arteries and veins).

They remove things from the market for good reason, and
all too often, too, too late.

The way to avoid adhesions takes place during the operation.
Attempting to -chemically- reduce or remove adhesions afterward,
is dangerous at the least!

Best wishes,

John

Nana b

John23 said:

Vioxx etc...

My wife suffered a ruptured cerebral aneurysm (2, actually)
as a direct result of taking VIOXX (It erodes the inside of
arteries and veins).

They remove things from the market for good reason, and
all too often, too, too late.

The way to avoid adhesions takes place during the operation.
Attempting to -chemically- reduce or remove adhesions afterward,
is dangerous at the least!

Best wishes,

John

I just got off celebrex, I'm
I just got off celebrex, I'm glad I did. It's so expensive for me to take anyway.

I still wonder about the antibiotic that I was on, and all my pains in the joints. I can't remember the name of it now, but it's one of the best out there but causes tendons to give out.

thingy45

Nana b said:

I just got off celebrex, I'm
I just got off celebrex, I'm glad I did. It's so expensive for me to take anyway.

I still wonder about the antibiotic that I was on, and all my pains in the joints. I can't remember the name of it now, but it's one of the best out there but causes tendons to give out.

I took Celebrex years ago
I took Celebrex years ago and wound up with a stomach bleeding. Cause was Celebrex I was told.

smokeyjoe

thingy45 said:

I took Celebrex years ago
I took Celebrex years ago and wound up with a stomach bleeding. Cause was Celebrex I was told.

They were suggesting just a
They were suggesting just a very short course of this before and after surgery, not long term from what I read, it seemed like what they suggested was just for days, not anything long tems, perhaps just during the inital healing process after surgery. I thing I read for something like 10 days only.