irinotecan +oxaliplatin
My mum onc mentioned about using irinotecan and oxaliplatin at the same time. Have any one of you been on this regimen?
I would like to explore more about it before we move to our next step.
Many thanks!
Dora
Comments
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me and
Hi Dora,
I'm on FOLFOXFIRI which is 5FU, oxaliplatin and irinotecan (CPT11). I know at least one other member of this board is on the same regime (sorry just forgot the name!).
It is considered a fairly brutul regime but I have done OK on it. Not much different from other "cocktails" I have been on (and I've been on lots!). Side effects for me have been: mild nausea, mild fatigue, mild temporary peripheral neuropathy (from oxi) and occasional bouts of diarrhea (from CPT-11). I know some others have sufffered quite serious diarrhea from the CPT11. Mine usually just lasts a couple of days and is controllable with a couple of Immodium. I've finished number 7 and about to do #8.
Good luck to your mum!!0 -
Dear TarataraHK said:me and
Hi Dora,
I'm on FOLFOXFIRI which is 5FU, oxaliplatin and irinotecan (CPT11). I know at least one other member of this board is on the same regime (sorry just forgot the name!).
It is considered a fairly brutul regime but I have done OK on it. Not much different from other "cocktails" I have been on (and I've been on lots!). Side effects for me have been: mild nausea, mild fatigue, mild temporary peripheral neuropathy (from oxi) and occasional bouts of diarrhea (from CPT-11). I know some others have sufffered quite serious diarrhea from the CPT11. Mine usually just lasts a couple of days and is controllable with a couple of Immodium. I've finished number 7 and about to do #8.
Good luck to your mum!!
Thank you very much for your detail descriptions. I just have one more question: do you have mouth sore and change of taste from this regimen? When my mum was on FOLFOX, she had serious mouth sore and change of taste and I wasn't sure if that was from oxaliplatin or 5-Fu.
Best wishes to you and your treatments.
Dora0 -
Dearest Doraluvmum said:Dear Tara
Thank you very much for your detail descriptions. I just have one more question: do you have mouth sore and change of taste from this regimen? When my mum was on FOLFOX, she had serious mouth sore and change of taste and I wasn't sure if that was from oxaliplatin or 5-Fu.
Best wishes to you and your treatments.
Dora
I had very few mouth sores on oxy. On 5fu I had a very bad time with mouth sores, cracked lips, eyes etc.
but eeryone is so different Dora....can only tell you that is was the 5FU for me.
Tara i cannot believe how well you are doing on that cocktail....gooooo girl!!
maggie0 -
side effectsluvmum said:Dear Tara
Thank you very much for your detail descriptions. I just have one more question: do you have mouth sore and change of taste from this regimen? When my mum was on FOLFOX, she had serious mouth sore and change of taste and I wasn't sure if that was from oxaliplatin or 5-Fu.
Best wishes to you and your treatments.
Dora
While side effects are very different for everyone, she can certainly expect change of taste - that happens on almost every chemo. I have had mouth sores on every combination I have been on. They were the worst on FOLFOX. I have not had Oxaliplatin and Irinotecan together. Normally when they put the two together, 5-FU or Xeloda is part of it. Oxaliplatin works best WITH 5-FU, but Irinotecan can be used on its own. I would question using Oxy + Irinotecan w/o 5-FU or Xeloda - ask for statistics on effectiveness.0 -
Oxaliplatin and IrenotecanKathryn_in_MN said:side effects
While side effects are very different for everyone, she can certainly expect change of taste - that happens on almost every chemo. I have had mouth sores on every combination I have been on. They were the worst on FOLFOX. I have not had Oxaliplatin and Irinotecan together. Normally when they put the two together, 5-FU or Xeloda is part of it. Oxaliplatin works best WITH 5-FU, but Irinotecan can be used on its own. I would question using Oxy + Irinotecan w/o 5-FU or Xeloda - ask for statistics on effectiveness.
Hi: I too am on folfoxfiri (Oxaliplatin + Irenotecan + 5FU pump + leucovin). My first chemo regime was cisplatin/gemcitibine. I have just today finished my 9th folfoxfiri treatment. My oncologist is using it to stabilize/shrink/remove nodules on my peritoneum which seeded from my gallbladder tumour (removed with part of my liver April 2010). It is a new treatment here in Canada as both gallbladder cancer and peritoneum cancer are very rare. I think I have 3 more treatments. My latest MRI showed shrinkage, stability, and removal of the peritoneum nodules (I had 6 little ones at the start) so my oncologist is thrilled and is recommending me for the peritoneum stripping/HIPEC surgery which is only done in one city here in Canada (Calgary).
As far as side effects...well, this is a tougher regime than the cisplatin/gemcitibine treatment (I have no side effects with that one) but the side effects are largely controllable. Oxaliplatin is well known for its neuropathy. I had it bad at the first treatment but started taking supplements (L-Glutamine fermented, Alpha lipoic acid, Vit B6, calcium/magnesium) and have had few problems since.The oncologist also reduced the amount and infusion rate. The others are known for severe diarrhea and I certainly get that starting 2 days after the 5FU pump is removed. I take lomotil for that starting right after the pump is removed. The fatigue - well, it too starts 2 days after the pump is removed and the only thing I do is walk my dog and take sips of an energy drink like RockStar. I also get the sweats apparently from the steroids given during chemo. I did not have a change in taste fortunately. I can't do Xeloda here in Canada - would cost far far too much (I already have to pay for the oxaliplatin and xeloda is more costly).
Good luck!
Cheryl0 -
mouth soresluvmum said:Dear Tara
Thank you very much for your detail descriptions. I just have one more question: do you have mouth sore and change of taste from this regimen? When my mum was on FOLFOX, she had serious mouth sore and change of taste and I wasn't sure if that was from oxaliplatin or 5-Fu.
Best wishes to you and your treatments.
Dora
HI Dora,
I haven't had serious mouth sores on this regime but definitely sensitivity --and change in taste (lasts less than one week). I gargle with soluble aspirin 1-2 times a day (oncologist's recommendation -- seems to help.....Don't use alcohol-based mouthwashes - ouch!0 -
sister!westie66 said:Oxaliplatin and Irenotecan
Hi: I too am on folfoxfiri (Oxaliplatin + Irenotecan + 5FU pump + leucovin). My first chemo regime was cisplatin/gemcitibine. I have just today finished my 9th folfoxfiri treatment. My oncologist is using it to stabilize/shrink/remove nodules on my peritoneum which seeded from my gallbladder tumour (removed with part of my liver April 2010). It is a new treatment here in Canada as both gallbladder cancer and peritoneum cancer are very rare. I think I have 3 more treatments. My latest MRI showed shrinkage, stability, and removal of the peritoneum nodules (I had 6 little ones at the start) so my oncologist is thrilled and is recommending me for the peritoneum stripping/HIPEC surgery which is only done in one city here in Canada (Calgary).
As far as side effects...well, this is a tougher regime than the cisplatin/gemcitibine treatment (I have no side effects with that one) but the side effects are largely controllable. Oxaliplatin is well known for its neuropathy. I had it bad at the first treatment but started taking supplements (L-Glutamine fermented, Alpha lipoic acid, Vit B6, calcium/magnesium) and have had few problems since.The oncologist also reduced the amount and infusion rate. The others are known for severe diarrhea and I certainly get that starting 2 days after the 5FU pump is removed. I take lomotil for that starting right after the pump is removed. The fatigue - well, it too starts 2 days after the pump is removed and the only thing I do is walk my dog and take sips of an energy drink like RockStar. I also get the sweats apparently from the steroids given during chemo. I did not have a change in taste fortunately. I can't do Xeloda here in Canada - would cost far far too much (I already have to pay for the oxaliplatin and xeloda is more costly).
Good luck!
Cheryl
Hi Cheryl -- Sorry I couldn't remember your name! Chemo brain! Yes -- you champion. You are 2 ahead of me - -I've completed #7 and about to do #8.
Good luck!
Tara0 -
Mouth SorestaraHK said:mouth sores
HI Dora,
I haven't had serious mouth sores on this regime but definitely sensitivity --and change in taste (lasts less than one week). I gargle with soluble aspirin 1-2 times a day (oncologist's recommendation -- seems to help.....Don't use alcohol-based mouthwashes - ouch!
Hi: I get them every once in awhile, particulary if I'm dumb enough to have something spicy. The oncologist here prescribed a wonderful mouth wash called Benzydamine Hcl 0.15% mixed with sucralfate in equal parts (the pharmacist mixes it up for me). You swish and spit 2-4 tspns four times daily before meals and bed. Works well!
Cheryl0
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