positif biopsy

khalidg

hello everybody

my father had a PSA of 13 than a positif DRE, the urologist asked for a biopsy whitch came back postif, it said at the report of the biopsy:

gleason grade 4, gleson score 4+4=8 in 42% of the sample that was examinated
can you please explain to me what does that mean

VascodaGama

If in good health he has same choices of treatment
Khalid

Your father with a Gleason 8 is classified as a High Risk Patient. The PSA=13 is also high and he had a positive DRE which indicates that he may have extracapsular extension. The Gleason pattern 4 is an aggressive type of cancerous cells and he needs to get treatment soon. You can find more details of his diagnosis in the pathologist report or you can ask his doctor.
I do not know the age of your father but if in good health he has same choices of treatment such as radiation and hormonal therapy, or a combination of both. Surgery may not be advisable because of the high possibility in recurrence which means that he would require a salvage treatment latter.

You could help him in understanding the matters of the diagnosis and treatments by reading articles published in the net. Just google “Prostate Cancer Treatments and Side effects”. A recommended book for his status is “Beating Prostate Cancer; Hormonal Therapy and Diet” by Dr. Charles Myers (himself a cancer survivor). You can buy a used copy on sale at the Amazon site.

Hope you find a satisfying treatment for his case.

Welcome to the board.
VGama

khalidg

VascodaGama said:

If in good health he has same choices of treatment
Khalid

Your father with a Gleason 8 is classified as a High Risk Patient. The PSA=13 is also high and he had a positive DRE which indicates that he may have extracapsular extension. The Gleason pattern 4 is an aggressive type of cancerous cells and he needs to get treatment soon. You can find more details of his diagnosis in the pathologist report or you can ask his doctor.
I do not know the age of your father but if in good health he has same choices of treatment such as radiation and hormonal therapy, or a combination of both. Surgery may not be advisable because of the high possibility in recurrence which means that he would require a salvage treatment latter.

You could help him in understanding the matters of the diagnosis and treatments by reading articles published in the net. Just google “Prostate Cancer Treatments and Side effects”. A recommended book for his status is “Beating Prostate Cancer; Hormonal Therapy and Diet” by Dr. Charles Myers (himself a cancer survivor). You can buy a used copy on sale at the Amazon site.

Hope you find a satisfying treatment for his case.

Welcome to the board.
VGama

hiw can we know the satge of the cancer
is there any possibilitie to know the satge of the cancer from the gleason score?

VascodaGama

khalidg said:

hiw can we know the satge of the cancer
is there any possibilitie to know the satge of the cancer from the gleason score?

The pathologist who did the analysis should give him the stage
Khalid

To grade the stage of your father’s case you need several data from the biopsy’s pathologist report. Gleason score and DRE are important information but the number of positive cores taken from each prostate lobo, their percentage of cancer as well as any findings related to extracapsular extension verified in the cores or from an image study such as CT or MRI, to access any metastasis, became crucial for the classification.

I believe that the pathologist who did the analysis is the right person to give you his stage. Based on the info you give above, your father could be stage II (T2) or III (T3). In the old system it would be stage B or C. If metastases are present, then it would be stage IV.

You can find the meaning of stages in this site;
http://www.psa-rising.com/prostatecancer/staging.htm

Hope this helps in your quest.
VGama