I think I must have low-grade ovarian cancer. I was diagnosed in January of 2006. Altogether, I was on at least 6 different chemos and even added Avastin but my CA-125 would briefly fall and then would start climbing again usually before I finished any of the rounds. I started going to MD Anderson Houston, in September 2009. My doctor decided to try a estrogen blocker and my numbers started to fall like a rock. It has been 18 months since I started the medication (a little gold pill taken once a day) and have done great. Unfortunately, my CA-125 has started to rise again. Does anyone know if changing to a different estrogen blocker is likely to stop the growth of tumors or if the tumors are now resistant to all estrogen blockers? I am so scared. I had foolishly began to think maybe I would be free of chemo now.