I completed 3 cycles of RCHOP - at the finish of the first tx I was given an injection of 6 mg of Neulasta as a preventative to nertropenia. My side effects were horrible - lots of bone pain, joint and body aches, head ache, jaw pain, gum pain, teeth pain ear aches etc. The next two cycles we cut the dose to 3 mg to see if it would take care of it. The pharmacist also suggested trying claritin to reduce side effects. Although not as bad as on the higher dose the constant pain and tiredness is putting be into a real funk. My WBCs and neutrophils are fine. I am going to talk to my doctor about skipping the neulasta. I am off work during this time and feel I can protect myself from infection. Are others doing RCHOP without using neulasta or neupogyn? It seems I have read a number of posts where folks don't start it until there is a problem - not before.