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Different chemotherapy treatments for CC. with K-ras mutated.

pepebcn
pepebcn CSN Member Posts: 6,331 Member
edited March 2014 in Colorectal Cancer #1
Are you aware about the different choices in the US?
Not all drugs approved by the FDA are approved here by EMA so l would like to know
which are the choices in the US.
Thanks Folks!
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Comments

  • ktlcs
    ktlcs CSN Member Posts: 358
    #2
    Erbitux
    is often used with wild type KRAS with some good results

    Kathy
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  • pepebcn
    pepebcn CSN Member Posts: 6,331 Member
    #3
    ktlcs said:

    Erbitux
    is often used with wild type KRAS with some good results

    Kathy

    Kathy thank you for your prompt response, are you sure?
    l thought Cetuximab, is only working with normal Kras!
    Any way if you know any positive experience with Cetuximab and people with mutated kras let me know!
    Thank you so much!
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  • Betsydoglover
    Betsydoglover CSN Member Posts: 1,248 Member
    #4
    ktlcs said:

    Erbitux
    is often used with wild type KRAS with some good results

    Kathy

    Wild-type KRAS
    Right - just a comment on the original title. "Wild-type" KRAS is the non-mutated type rather than the mutated type.

    Erbitux and Vectibix are not effective in mutated KRAS. However, there is some research going on and at least one trial somewhere aimed at seeing if another new drug combined with Erbitux can possibly make it effective in mutated KRAS patients.

    Betsy (a mutant)
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  • ktlcs
    ktlcs CSN Member Posts: 358
    #5
    Betsydoglover said:

    Wild-type KRAS
    Right - just a comment on the original title. "Wild-type" KRAS is the non-mutated type rather than the mutated type.

    Erbitux and Vectibix are not effective in mutated KRAS. However, there is some research going on and at least one trial somewhere aimed at seeing if another new drug combined with Erbitux can possibly make it effective in mutated KRAS patients.

    Betsy (a mutant)

    Yes
    Erbitux is used for people with wld type KRAS not the mutated gene
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  • pepebcn
    pepebcn CSN Member Posts: 6,331 Member
    #6
    ktlcs said:

    Yes
    Erbitux is used for people with wld type KRAS not the mutated gene

    thank you kathy it seems
    My English is causing me certain misunderstandings!
    Thank you!
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  • pepebcn
    pepebcn CSN Member Posts: 6,331 Member
    #7
    Betsydoglover said:

    Wild-type KRAS
    Right - just a comment on the original title. "Wild-type" KRAS is the non-mutated type rather than the mutated type.

    Erbitux and Vectibix are not effective in mutated KRAS. However, there is some research going on and at least one trial somewhere aimed at seeing if another new drug combined with Erbitux can possibly make it effective in mutated KRAS patients.

    Betsy (a mutant)

    Ohhh sorry! my English some times causes me certain troubles
    hahaha! l will edit it now!
    tank you both two!
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  • pepebcn
    pepebcn CSN Member Posts: 6,331 Member
    #8
    Betsydoglover said:

    Wild-type KRAS
    Right - just a comment on the original title. "Wild-type" KRAS is the non-mutated type rather than the mutated type.

    Erbitux and Vectibix are not effective in mutated KRAS. However, there is some research going on and at least one trial somewhere aimed at seeing if another new drug combined with Erbitux can possibly make it effective in mutated KRAS patients.

    Betsy (a mutant)

    Betsy l have seen you have been treated with xeloda,
    did it worked in a mutant?
    thanks for your interest .
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  • snommintj
    snommintj CSN Member Posts: 601
    #9
    pepebcn said:

    Betsy l have seen you have been treated with xeloda,
    did it worked in a mutant?
    thanks for your interest .

    trials
    There is a bunch of stuff going on with Gemzar and erbitux for folks who would normally be uneffected by erbitux alone. There are some early signs of success.
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  • coloCan
    coloCan CSN Member Posts: 1,944 Member
    #10
    snommintj said:

    trials
    There is a bunch of stuff going on with Gemzar and erbitux for folks who would normally be uneffected by erbitux alone. There are some early signs of success.

    Something called "Imprime PGG" added to Erbitux improves
    the response for those with the wild type of KRAS, as per businesswire article on July 5, 2010.....steve
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