Different hormone results - initial pathology vs. Oncotype Dx

Double Whammy

My initial pathology on my breast tumor biopsy was Estrogen positive, Progesterone negative, HER-2 negative.

I subsequently had an oncotype DX test and the ER, PR and HER2 scores were repeated. The report clearly says that "these results may differ from ER, PR, or HER2 results reported using other methods or reported by other laboratories". There is a difference for me. The Oncotype DX results say "PR = 5.8 positive. The positive/negative cut off of 5.5 units was validated from a study of 761 samples using the PR636 antibody (immunohistochemistry) and another study of 607 samples using the Pr 636 antibody (immunohistochemistry). The standard deviation for the PR score is less than 0.5 units".

I just noticed this and I will ask my oncologist about it, but what do you think? Is this a discrepancy?

Thanks.

Suzanne

cahjah75

I don't
Suzanne, I don't know. My initial pathology report stated that I was ER+, PR+ and HER2-. I see my oncologist on Monday and plan on asking him about the OncotypeDx test.
Char