Neuropathy 'prevention' info

dianetavegia Member Posts: 1,942 Member
edited March 2014 in Colorectal Cancer #1
Shands Teaching Hospital article

Glutathione: Glutathione is a small protein that is involved in detoxification; it binds to toxins in the body and transforms them into a form that can be excreted in urine or bile. Glutathione appears to significantly reduce numbness and tingling in the extremities, which is a common side effect of the chemotherapy drug Eloxatin.

In a clinical trial that involved 52 patients with advanced colorectal cancer undergoing Eloxatin chemotherapy, half were treated with glutathione and the other half received a placebo (inactive substitute). After eight courses of chemotherapy, only 43% of patients treated with glutathione experienced peripheral neuropathy, compared to 79% of patients who received placebo. Severe numbness and tingling did not occur in any patients treated with GSH, but occurred in 26% of patients who received placebo. Glutathione did not alter the effectiveness of chemotherapy, as anticancer responses, progression-free survival, and overall survival at nearly one year were the same between the two groups of patients


  • coloCan
    coloCan Member Posts: 1,944 Member
    Thanks for the info
    Wed I;ll ask onc about this, Thanks Diane......steve

    PS: just checked like glutathione is a very important antioxindant I was not familiar with,,,,,
  • ann2008
    ann2008 Member Posts: 118
    Is this a prescription med? I just went to MD today and he was hoping my neuropathy would be resolved or minimal by now. He increased my neurontin dose hoping this will help. Will check into this. Thanks, Ann