Mom's Pathology Report

A1pena

Hi There,

We got my mom's pathology report today and wanted to share the results with you. Would be great to hear some thoughts and compare notes. So here goes:

FIGO Grade 3 Serous Adenocarcinoma
Stage 3C
Myometrial invasion at 80%
Tumor size 8cm in uterus and 3.1cm in cervix, ovaries and f. tubes were clear
Lymph Nodes: 124 removed!!!! 104 positive!!! crazy I know- just glad they are out- phew!
Margins- Negative
Pelvic/abdominal Cytology- negative
Omentum- negative
CEA- negative
Vimentin- focally positive
ER- patchy positive in tumor
p53- diffusely positive in tumor
WT1- patchy positive in tumor
p16- diffusely positive in tumor
CA 125= 50 pre surgery (didnt do one post).

Do any of you see good/bad news with this? I'm researching the findings until we can meet with the doctor again but with so much info out there its hard sift through. They didnt do any functional profiling or testing for EGFR which bummed us out. I understand that she has an aggressive cancer with high chance for recurrence- moreso trying to see how this will help/hurt her prognosis.

THANK YOU!!!

Olga and Amanda

lindaprocopio

Grade 3-c UPSC: just like me.
((((Olga & Amanda)))). Well, the Serous Adenocarcinoma is definitely UPSC, but I assume you knew that. The p53 is interesting, and I'll have to check my notes, but that may make her a good candidate for Avastin as a part of her chemo cocktail. I think P53 testing is pretty close to functional profiling. Use the SEARCH feature on this Board and put in "p53" and see what posts come up. I think we have good research on that posted here somewhere.

The negative Pelvic/abdominal Cytology is good news: always better not to have cancer cells floating around in the wash; you can take some comfort there for sure. That was a crazy amount of lymph nodes they removed (124!!! I thought when I had 25 removed that was a lot! wow!) but her surgeon obviously saw problems and took that many as a part of the 'optimal debulking' so you can feel good about your surgeon that he was aggressive. Seeing how many of the nodes were positive, you know that he did the right thing. The myometrial invasion depth isn't that much of a prognosis indicator with UPSC as other uterine cancers. With Stage 3 UPSC, chemo is a must, for sure.

A1pena

lindaprocopio said:

Grade 3-c UPSC: just like me.
((((Olga & Amanda)))). Well, the Serous Adenocarcinoma is definitely UPSC, but I assume you knew that. The p53 is interesting, and I'll have to check my notes, but that may make her a good candidate for Avastin as a part of her chemo cocktail. I think P53 testing is pretty close to functional profiling. Use the SEARCH feature on this Board and put in "p53" and see what posts come up. I think we have good research on that posted here somewhere.

The negative Pelvic/abdominal Cytology is good news: always better not to have cancer cells floating around in the wash; you can take some comfort there for sure. That was a crazy amount of lymph nodes they removed (124!!! I thought when I had 25 removed that was a lot! wow!) but her surgeon obviously saw problems and took that many as a part of the 'optimal debulking' so you can feel good about your surgeon that he was aggressive. Seeing how many of the nodes were positive, you know that he did the right thing. The myometrial invasion depth isn't that much of a prognosis indicator with UPSC as other uterine cancers. With Stage 3 UPSC, chemo is a must, for sure.

Thank you for your post
Thank you for your post Linda! Being that the p53 and p16 tests were diffusely positive really have us worried. From what I have been reading it sounds like it could be a mutation of the gene which leads to an even poorer prognosis Trying not to read to much into it but its tough.

Thanks again Linda,

Olga and Amanda

lindaprocopio

A1pena said:

Thank you for your post
Thank you for your post Linda! Being that the p53 and p16 tests were diffusely positive really have us worried. From what I have been reading it sounds like it could be a mutation of the gene which leads to an even poorer prognosis Trying not to read to much into it but its tough.

Thanks again Linda,

Olga and Amanda

I think I read that 60% of UPSC patients test positive
Please don't be too alarmed. I think I read that 60% of tested UPSC patients test positive for these factors. So your mother is not alone. I just popped in to post the hopeful opinion of my oncologist that I just got THIS MORNING! Even after my recurrance, my chemo-oncologist still holds hope for me for a CURE, or at least a prolonged multi-year remission!! I didn't think he still held out that hope; I had pretty much let that hope die in my heart. But, in light of my clear PET scan, he suggested that we do one more 'balls-to-the-wall' 4 months of full strength carbo/taxol again as an option, obviously feeling I had a good enough chance to still achieve a cure or a long remission to put my body through that again. So hope springs eternal! Try not to be afraid. I am getting a second opinion on Monday, and I had a CA-125 drawn this morning that I don't have the results of yet that will play into my decision. I guess I'm saying, do not dispair! It ain't over 'till it's over!

A1pena

lindaprocopio said:

I think I read that 60% of UPSC patients test positive
Please don't be too alarmed. I think I read that 60% of tested UPSC patients test positive for these factors. So your mother is not alone. I just popped in to post the hopeful opinion of my oncologist that I just got THIS MORNING! Even after my recurrance, my chemo-oncologist still holds hope for me for a CURE, or at least a prolonged multi-year remission!! I didn't think he still held out that hope; I had pretty much let that hope die in my heart. But, in light of my clear PET scan, he suggested that we do one more 'balls-to-the-wall' 4 months of full strength carbo/taxol again as an option, obviously feeling I had a good enough chance to still achieve a cure or a long remission to put my body through that again. So hope springs eternal! Try not to be afraid. I am getting a second opinion on Monday, and I had a CA-125 drawn this morning that I don't have the results of yet that will play into my decision. I guess I'm saying, do not dispair! It ain't over 'till it's over!

Great news!
OMG Linda- that is GREAT NEWS! and just the news I need to hear. Thank you so much for sharing your story and continually posting your progress. It has truly helped our family find the strength to fight this and take an active role in my mom's treatment.

Looking forward to continued great news!

hugs,

Amanda