have any of you asked your Onco....

alta29

about this vaccine ????
November 15, 2006, 4:31 AM CT

Vaccine Against Colorectal Cancer

British scientists have developed a vaccine that stimulates colorectal cancer patients' immune systems to fight malignant cells.

In a clinical trial of 67 patients, scientists at the University of Nottingham found that when the vaccines were administered before and after surgery to remove malignant tumors, they helped stimulated immune cell production in up to 70 percent of patients. These results are reported in the November 15 issue of Clinical Cancer Research.

"This is the first vaccine shown to stimulate TNF-alpha an immune-system protein that is very effective at killing cancer cells," said Lindy Durrant, senior author of the study and professor of cancer immunotherapy at the university.

The vaccine works by stimulating the patients' immune response to generate infection-fighting white blood cells called T cells, which in turn produce immune system proteins called cytokines that destroy cancer cells. The antibody contained in the vaccine, called 105AD7, was cloned from a patient who survived seven years with liver metastases from colorectal cancer, Durrant explained.

"

alta29

Just to add a note to it....I keep reading more and more about how much the inmune systems plays a role in cancer....I have been taking this inmune pills for a year now...( I take 6 of them a day..yeap... very expensive too) But I wondered if maybe..just maybe...when I had the recurrance...it just stayed in my lymph nodes,because of these vitamins...maybe I shoould take 20 a day !!! hahhahhah
Merry Christmas to you all...God bless
Ileana

CAMaura

alta29 said:

Just to add a note to it....I keep reading more and more about how much the inmune systems plays a role in cancer....I have been taking this inmune pills for a year now...( I take 6 of them a day..yeap... very expensive too) But I wondered if maybe..just maybe...when I had the recurrance...it just stayed in my lymph nodes,because of these vitamins...maybe I shoould take 20 a day !!! hahhahhah
Merry Christmas to you all...God bless
Ileana

Pretty interesting, and I have never heard of the vaccine. Great post, though. I really need to remind myself every single day to try to keep my immune system going strong - or stronger. Would you mind talking a bit about the immune pills - herbal, mushroom-based, a mixture?
Thanks and have a great Holiday!! - Maura

shmurciakova

Are you taking IP-6 w/ Inositol? That is what I have been taking but I only take 4xday, however, I have heard you can take much, much more than that. If not, what are you taking?
My friend sent this article to me a few weeks ago. I hope it is something that can be used to prevent recurrences!
If anyone has spoken to their doc about this, please let us know what they said.
-Susan

only54

Is this the one they are calling TroVax? I have read a little about that one and I asked my oncologist about it. He had not heard of it - I am trying to find a clinical trial for it - there is a doctor in Texas working with it but from what I can find out - it is only for kidney cancer. If anyone has any other information - I would be most appreciative. Hope you all had a great Christmas.

Rita

shmurciakova

only54 said:

Is this the one they are calling TroVax? I have read a little about that one and I asked my oncologist about it. He had not heard of it - I am trying to find a clinical trial for it - there is a doctor in Texas working with it but from what I can find out - it is only for kidney cancer. If anyone has any other information - I would be most appreciative. Hope you all had a great Christmas.

Rita

This is definitely for colon cancer, but it may have other uses I am not sure. Here is the rest of the article......

New Vaccine Stimulates Colorectal Cancer Patient’s Immune Systems to Fight Cancerous Cells


105AD7 is structurally similar to CD55, a protein that attaches to sugar molecules and is overexpressed in colorectal cancer cells, protecting them from attack by the body's immune system. While low levels of CD55 occur in all cells exposed to the immune system, increased expression of the protein has been observed in multiple types of tumors, including up to 80 percent of colorectal cancers.

During the trial -- the largest to date looking at 105AD7 plus surgery -- 67 patients with colorectal cancer who were scheduled for surgery to remove their primary tumor were randomly assigned to receive either 100 micrograms of 105AD7 with a powder to help absorb the vaccine, 105AD7 along with BCG (a bacteria used to stimulate the immune system in cancer patients) during the first immunization and the powder in subsequent vaccinations, or no treatment. The patients, who had varying degrees of disease, averaged age 66. Twenty-eight patients had colon cancer while in 39 patients the primary tumor was located in the rectum.

Patients were immunized before surgery on the day they were recruited for the study, and again two weeks later if surgery had not yet been performed. The vaccines were continued three, six and 12 weeks after surgery, and then at three monthly intervals up to a maximum of 24 months after surgery. Blood samples were collected from the patients during recruitment, at surgery, and at the time of the three-, six- and 12-week post-operative immunizations. Additional blood samples were acquired one month after each subsequent immunization.

Laboratory tests of the blood samples indicated that a T-cell response against the vaccine was recorded in the majority of patients. The responses tended to have two peaks: one following the start of the immunization schedule and another several months later, after additional immunizations. About 70 percent of patients produced both TNF-alpha and GM-CSF - a protein that stimulates white blood cell production - in response to both the vaccine and to CD55.

"The immune responses to both the vaccine and CD55 were measurable, adding support to the use of CD55 as a target in cancer treatment," Durrant said.

Nineteen of the patients died during the follow-up period. Durrant and colleagues noted that the trial was not designed to study the effect of the vaccines on survival.

The research was supported by The Research Foundation Stiftelsen Onkologiska Klinikens i Uppsala Forskningsfond.

# # # #

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes more than 24,000 basic, translational, and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 70 other countries. AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care. AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship, and advocacy.

only54

shmurciakova said:

This is definitely for colon cancer, but it may have other uses I am not sure. Here is the rest of the article......

New Vaccine Stimulates Colorectal Cancer Patient’s Immune Systems to Fight Cancerous Cells


105AD7 is structurally similar to CD55, a protein that attaches to sugar molecules and is overexpressed in colorectal cancer cells, protecting them from attack by the body's immune system. While low levels of CD55 occur in all cells exposed to the immune system, increased expression of the protein has been observed in multiple types of tumors, including up to 80 percent of colorectal cancers.

During the trial -- the largest to date looking at 105AD7 plus surgery -- 67 patients with colorectal cancer who were scheduled for surgery to remove their primary tumor were randomly assigned to receive either 100 micrograms of 105AD7 with a powder to help absorb the vaccine, 105AD7 along with BCG (a bacteria used to stimulate the immune system in cancer patients) during the first immunization and the powder in subsequent vaccinations, or no treatment. The patients, who had varying degrees of disease, averaged age 66. Twenty-eight patients had colon cancer while in 39 patients the primary tumor was located in the rectum.

Patients were immunized before surgery on the day they were recruited for the study, and again two weeks later if surgery had not yet been performed. The vaccines were continued three, six and 12 weeks after surgery, and then at three monthly intervals up to a maximum of 24 months after surgery. Blood samples were collected from the patients during recruitment, at surgery, and at the time of the three-, six- and 12-week post-operative immunizations. Additional blood samples were acquired one month after each subsequent immunization.

Laboratory tests of the blood samples indicated that a T-cell response against the vaccine was recorded in the majority of patients. The responses tended to have two peaks: one following the start of the immunization schedule and another several months later, after additional immunizations. About 70 percent of patients produced both TNF-alpha and GM-CSF - a protein that stimulates white blood cell production - in response to both the vaccine and to CD55.

"The immune responses to both the vaccine and CD55 were measurable, adding support to the use of CD55 as a target in cancer treatment," Durrant said.

Nineteen of the patients died during the follow-up period. Durrant and colleagues noted that the trial was not designed to study the effect of the vaccines on survival.

The research was supported by The Research Foundation Stiftelsen Onkologiska Klinikens i Uppsala Forskningsfond.

# # # #

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes more than 24,000 basic, translational, and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 70 other countries. AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care. AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship, and advocacy.

http://www.medicalnewstoday.com/medicalnews.php?newsid=33840. Here is the link to the TroVax article. I think we are talking about two different vaccines but I am not sure.

Rita

shmurciakova

only54 said:

http://www.medicalnewstoday.com/medicalnews.php?newsid=33840. Here is the link to the TroVax article. I think we are talking about two different vaccines but I am not sure.

Rita

Hi again,
From what I can gather from reading this, TroVax targets a protein called 5T4 while the vaccine mentioned here targets a protein CD55. All of this is very confusing, especially when they use a "brand name" like TroVax. However, I do think these are two different vaccinations. A good question for your doctor...
However, the more the better. It sounds like the one below (105AD7) is not as far along in the process as TroVax which is why it is not yet named. Hey, is this the one that guy Mark was in a clinical trial for? Remember him, the one who's caregiver always writes in. I cannot remember her user name now......
At any rate, it is good news that new therapies are in the works.
-Susan

StacyGleaso

I have first-hand information about this from an investment standpoint. Rather than bore everyone with statistics, e-mail me through this site if you're interested in more information.

It's not a preventative measure, but to treat those already dianosed.

Hugs,
Stacy

StacyGleaso

StacyGleaso said:

I have first-hand information about this from an investment standpoint. Rather than bore everyone with statistics, e-mail me through this site if you're interested in more information.

It's not a preventative measure, but to treat those already dianosed.

Hugs,
Stacy

Diagnosed, that is....dang chemo brain and fast fingers! lol

StacyGleaso

StacyGleaso said:

I have first-hand information about this from an investment standpoint. Rather than bore everyone with statistics, e-mail me through this site if you're interested in more information.

It's not a preventative measure, but to treat those already dianosed.

Hugs,
Stacy

Diagnosed, that is....dang chemo brain and fast fingers! lol