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New Treatment for Liver Mets

shmurciakova
CSN Member Posts: 906 Member
Trans-arterial chemoembolization (TACE) of liver metastases from colorectal cancer using irinotecan-eluting beads: preliminary results.
Aliberti C, Tilli M, Benea G, Fiorentini G.
Department of Interventional Radiology Delta Hospital, via delle Tombe 65, 47023 Lagosanto, Ferrara, Italy. camy.ali@libero.it
PURPOSE: The purpose of the study was to evalutate the feasibility of irinotecan drug-eluting beads (DC Bead) administered as trans-arterial chemoembolization (TACE) in patients with liver metastases from colorectal cancer (CRC). PATIENTS AND METHODS: Ten patients with liver metastases from CRC were treated with TACE adopting irinotecan-eluting beads at a dose of 100 mg every 3 weeks. Computed Tomography (CT) was performed 24h before and after TACE. RESULTS: TACE with irinotecan eluting beads was found to be feasible and well-tolerated. Right upper quadrant pain (RUQP) lasting 4 days (range 2-7) was reported by all the patients. After 30 days, a reduction >50% of CEA levels and of the lesional contrast enhancement was observed in all the patients. Conclusion: Irinotecan drug-eluting beads administered as TACE were shown to be active and safe in patients with liver metastases from CRC.
Aliberti C, Tilli M, Benea G, Fiorentini G.
Department of Interventional Radiology Delta Hospital, via delle Tombe 65, 47023 Lagosanto, Ferrara, Italy. camy.ali@libero.it
PURPOSE: The purpose of the study was to evalutate the feasibility of irinotecan drug-eluting beads (DC Bead) administered as trans-arterial chemoembolization (TACE) in patients with liver metastases from colorectal cancer (CRC). PATIENTS AND METHODS: Ten patients with liver metastases from CRC were treated with TACE adopting irinotecan-eluting beads at a dose of 100 mg every 3 weeks. Computed Tomography (CT) was performed 24h before and after TACE. RESULTS: TACE with irinotecan eluting beads was found to be feasible and well-tolerated. Right upper quadrant pain (RUQP) lasting 4 days (range 2-7) was reported by all the patients. After 30 days, a reduction >50% of CEA levels and of the lesional contrast enhancement was observed in all the patients. Conclusion: Irinotecan drug-eluting beads administered as TACE were shown to be active and safe in patients with liver metastases from CRC.
Comments
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I remember 2 years ago , when I started this journey...reading the cancer was going to be treated as a disease 2 years from then....maybe we are relly getting closer to it...I will have my first cea result tomorrow after I started chemo....staying really positive..will let u all know tomorow..
God bless
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