Hi My brother was diagnosed with aggressive form of Large B-cell with CNS involvement in July 2004. Had standard CHOP (8 cycles)and 4 cylces of Methotrexate for brain involvement from July to Dec '04. Was declared in remission after 4 cycles of CHOP in Oct '04 but cancer relapsed in January '05. After 3 weeks of radiation, my brother was admitted to the hospital for a autogolous stem cell transplant (his own bone marrow) and has been out of the hospital for 4 weeks. Yesterday, we discovered "bits" of the disease in the spine. (We are at a loss as to why the transplant didn't work given all but 10 of his white cells were erradicated by chemo) I'm very interested in others stories and potential experimental treatments that may be used now that standard treatments have been exhausted (i.e clinical trials, mini-transplants, new drugs etc) I'm looking to get as much info and perspective as possible....please reply with any info or perspective from your experiences.