Yes, I have been taking Effexor for about a year now and I am down to a few mild hot flashes a day. I started out at 12.5 mg twice a day for one week; then 25 twice a day for some months. When I told my oncologist that the Effexor was helping but did not completely stop the flashes, he increased the dose to 75 a day, and that is the dose I take now. I experience no side effects whatever, and consider the flashes I do have usually tolerable. By the way, I have been taking Tamoxifen for 3 1/2 years now. It will be interesting to see when I stop after 5 years if the hot flashes go away completely or if I'll still need the Effexor.