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Poorly differeniate diffuse signet ring cells

Posts: 26
Joined: Jun 2010

In the world of stomach cancer how aggressive is this type of cancer cell. We were asked to be tested (whole family) for the CDH1. Is this cancer type linked to the genetic carrying cancer? Thanks


Terri Lou
Posts: 4
Joined: Aug 2010

Hi Ellen
CDH1 is a genetic mutation that is known to cause Hereditary Diffuse Gastric cancer. However, HDGC has been known to run in families that do not carry the CDH1 mutation. This is very rare and represents only a fraction of stomach cancers. Any family that finds clusters of gastric cancer, particularly early onset (age 50 or under) should become informed about CDH1 and HDGC.
As far as it being aggressive, that's not how I would describe it at all. More like "sneaky." This cancer does not form large tumors, rather the cells are scattered and often hiding in the stomach lining. Because of this, it is very hard to detect until it has spread. I would refer you to the website
There you will find lots of information and links to even more information about this condition.

Posts: 7
Joined: Nov 2010

I had a Roux n Y a year ago this month. I had an EGD 3 weeks ago and the biopsies were all negative for cancer. I was told signet cell gastric cancer is caused by having had a previous gastrectomy, I had a gastrectomy 40 years ago. Signet cell cancer is supposed to be the "best" type of gastric cancer. My cancer was poorly differentiated but encapsulated in a gasric polyp.I would not think this would be genetic. What does her surgeon say about it? Diane

Posts: 2
Joined: May 2017

I also have "poorly differentiated" and "diffuse signet cell type" adenocarcinoma. I had most of my stomach removed, followed by 5FU chemotherapy plus radiation. After that ended, my oncologist started me on the "XELOX" regimen (Xeloda plus oxaliplatin). I was wondering if anybody else received this treatment, or has any experience with it. 

Posts: 3
Joined: Jun 2017

Please see my post from today--we are in the same boat!

Posts: 3
Joined: Jun 2017

I am on EOX--Xeloda and Oxaliplatin included. Not fun.

Posts: 4
Joined: Jun 2017

Hello Sima,

My husband was diagnosed with the same as you in the first week of April 2017. He had first chemo on apr 26 and second on may 16. His treatment is ECX every 3 weeks. He is on Xeolda from the beginning.  He is 53. He did not have any side effects other than hair loss.  How are you doing?  I am very emotional. I have 3 young kid. I hope you are feeling better.

Posts: 3
Joined: Oct 2017

Helo sima,

I had right ovarian mass which was removed on july 2016 it showed signet ring cell.investigations were done to find primary site of lesion.they found cancer poorly differenciated adenocarcinoma in my stomach ,so was given 6 cycles of chemo DCF regimen,and was on xeloda 2000mg per day but my pet scan of october 2017 showed left ovarian mass so left ovary was also removed.now there is no evidence of cancer elsewhere.but dr adviced me for EOX chemo.hw r u tolerating EOX regimen?previously i had DCF regimen lost all my hairs and was extremely weak for 7-8days after every cycle of chemo.is it the same with EOX?

Posts: 3
Joined: Jun 2017

I also have "poorly differentiated" and "diffuse signet cell type" gastric adenocarcinoma. I was diagnosed on April 13 and was fully staged (4) by May 10, the date of my first EOX chemo treatment--3 cycles, then will re-stage. I am in the Bay Area, treated at Alta Bates and consulting at Stanford. I am looking into possibly HIPEC (CA options for HIPEC include City of Hope in L.A. and UCSD). Scared but taking it day-by-day. I welcome input! 

Posts: 4
Joined: Jun 2017

Hope you feel better.  Any side effects?  keep in touch

Posts: 3
Joined: Aug 2017

My sister has been diagnosed with stage IV, signet cell adenocarcinoma of the stomach and we are desperate to find a hospital, cancer center, or doctor that is familiar with kind of cancer. Also what kind of chemo and treatments have others received that can slow this runaway train down. Any and all help is appreciate.

Thank you


Posts: 1
Joined: Dec 2017

Hello: Am new to this forum. My husband was diagnosed with stage 4 signet ring carcinoma in October of 2015. Surgeon diagnosed it as colon cancer, and did a hemicolectomy excising hopefully all of the cancer in the colon. Biopsy showed it to be poorly differentiated. Then in August of 2017, he was having some belching, so a gastroenterologist did a scope on him and did a biopsy of some tissue. The diagnosis was changed to gastric cancer. The doctor said his type of cancer grows very flat, so technically it has never "shown" on any of his PET scans and CT scans. We have used two different oncologists as we were not happy with either one - just providing little knowledge and a reluctance to fully answer questions - extremely frustrating. Both oncologists had to have known that gastric cancer often grows flat, so they should not have told my husband that he was in remission. His chemo was cut back, then the stomach scope of August 2017, which changed the doctor's mind on remission. Twice, his doctor has told him that he is surprised my husband has lasted this long - that is really not a compliment and a patient does not need to hear this, for pete's sake. Could write volumes on the insensitivity of many physicians. My husband's doctor believes in systemic chemo and has been totally resistant to immunotherapy. Finally, he tested my husband and found him PDL1-negative, which means he is not a candidate for immunotherapy. The doctor also seems very reluctant to Hipec surgery and cannot really give a reason that I can comprehend. My husband is presently on Taxol and Cyramza as the other chemo finally gave too many side effects. Again, the cancer has not shown on any PET or CT scans, so we wonder how bad can it be? He feels pretty good except for tiredness. I know it seems like the thing to do would be to change doctors, but since we have changed already, my husband is reluctant to change again and doesn't want to spend a lot of time at a hospital like M.D. Anderson. If it was up to me, I'd move on to a third oncologist. Any advice from any of you fine people on anything I have written - would be much appreciated.

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