A little on Onco-VAX vaccine for Stage II CRC (plus two new):

coloCan
coloCan Member Posts: 1,944 Member
edited August 2012 in Colorectal Cancer #1
www.sacbee.com/2012/08/27/4760103/human-vaccines-immunotherapeutics.html

Some interesting trials:TAS-102

medicalxpress.com/news/2012-08-drug-trial-patients-advanced-colorectal.html

and avastin,temsirolimus and liposomal doxorubicin:

clincancerres.aacrjournals.org/content/early/2012/08/25/1078-0432.CCR-12-1158.abstract

Comments

  • k1
    k1 Member Posts: 220
    future vaccines for CRC patients based on individual genetics
    Awesome news about the future vaccine for Stage 2 CRC patients. This is the same company that has the test out since 2010 for Stage 2 diagnosed patients that predicts risk of recurrence or effectiveness of chemo based on individual tumor genetics, isn't it?

    K1
  • So Worried
    So Worried Member Posts: 111
    k1 said:

    future vaccines for CRC patients based on individual genetics
    Awesome news about the future vaccine for Stage 2 CRC patients. This is the same company that has the test out since 2010 for Stage 2 diagnosed patients that predicts risk of recurrence or effectiveness of chemo based on individual tumor genetics, isn't it?

    K1

    Wow
    This is very interesting as my hubby is stage 2a. I wonder what it means exactly?
  • coloCan
    coloCan Member Posts: 1,944 Member
    k1 said:

    future vaccines for CRC patients based on individual genetics
    Awesome news about the future vaccine for Stage 2 CRC patients. This is the same company that has the test out since 2010 for Stage 2 diagnosed patients that predicts risk of recurrence or effectiveness of chemo based on individual tumor genetics, isn't it?

    K1

    Don't know if this is still available from Nov,2010:
    "Study uses the patient's tumor to form vaccine" at:physorg.com/print209816809.html

    (Also,a biopsy from one part of a tumor may show different makeup than another section......)

    Here's a report from Jan,2012 from a German trial:fiercebiotech.com/print/node/297085
  • coloCan
    coloCan Member Posts: 1,944 Member
    coloCan said:

    Don't know if this is still available from Nov,2010:
    "Study uses the patient's tumor to form vaccine" at:physorg.com/print209816809.html

    (Also,a biopsy from one part of a tumor may show different makeup than another section......)

    Here's a report from Jan,2012 from a German trial:fiercebiotech.com/print/node/297085

    A little more on TAS-102:
    medpagetoday.com/HematologyOncology/ColonCancer/34443

    (Reolysin with Folfiri is also in trial)
  • steved
    steved Member Posts: 834
    TAS 102/OncoVax
    This looks interesting and would e interested to hear from anyone who is entering the new trial- tehre is a 800 patient international Phase 3 trial starting soon to look at TAS102 in people with refractory colorectal cancers. The Phase 2 trial was very (almost too) positive with increased tumour stability and survival- the results are more inpressive than the phase 2 trials in regorafenib and aflibercept- so good phase 3 results may lead to licensing failry quickly.

    Oncovax sounds interesting though seems a little unproven. It is interesting that they are going for FDA approval after only phase 2 trials so will be interesting to see if they get it. AGain the results sound a little too good to be true and there are many drugs that show great results at phase 2 and never make it to market as phase 3 trials (bigger, more robust and controlled trials) don't show similar results.

    Overall great to hear of lots of possible good developments but important not to get over excited about things that sound good in the media but are a fair way off being used widely.

    steve
  • steved
    steved Member Posts: 834
    TAS 102/OncoVax
    This looks interesting and would e interested to hear from anyone who is entering the new trial- tehre is a 800 patient international Phase 3 trial starting soon to look at TAS102 in people with refractory colorectal cancers. The Phase 2 trial was very (almost too) positive with increased tumour stability and survival- the results are more inpressive than the phase 2 trials in regorafenib and aflibercept- so good phase 3 results may lead to licensing failry quickly.

    Oncovax sounds interesting though seems a little unproven. It is interesting that they are going for FDA approval after only phase 2 trials so will be interesting to see if they get it. AGain the results sound a little too good to be true and there are many drugs that show great results at phase 2 and never make it to market as phase 3 trials (bigger, more robust and controlled trials) don't show similar results.

    Overall great to hear of lots of possible good developments but important not to get over excited about things that sound good in the media but are a fair way off being used widely.

    steve
  • janie1
    janie1 Member Posts: 753
    steved said:

    TAS 102/OncoVax
    This looks interesting and would e interested to hear from anyone who is entering the new trial- tehre is a 800 patient international Phase 3 trial starting soon to look at TAS102 in people with refractory colorectal cancers. The Phase 2 trial was very (almost too) positive with increased tumour stability and survival- the results are more inpressive than the phase 2 trials in regorafenib and aflibercept- so good phase 3 results may lead to licensing failry quickly.

    Oncovax sounds interesting though seems a little unproven. It is interesting that they are going for FDA approval after only phase 2 trials so will be interesting to see if they get it. AGain the results sound a little too good to be true and there are many drugs that show great results at phase 2 and never make it to market as phase 3 trials (bigger, more robust and controlled trials) don't show similar results.

    Overall great to hear of lots of possible good developments but important not to get over excited about things that sound good in the media but are a fair way off being used widely.

    steve

    I'm not able to read this on
    I'm not able to read about this on my phone.
    Question - Does this have to be given with another chemo.....like irinotecan, folfox, of folfuri......i hope not. Too many people ran the course on first and second lines. It would be so wonderfulllllllllll to have something new without having to mix it in with the old regimens.
    Thanks.