PARP inhibitors what do you know -updated with new question

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worriedson714
worriedson714 Member Posts: 333 Member
edited May 2021 in Colorectal Cancer #1

         So I been doing my research and found out that PARP inhibitors are used to treat cancer's with BRCA mutations . My dad has BRCA mutations but yet his oncologist told us targeted drugs won't work on my dad which has me confused . Anyone know anything about this PARP Inhibitors are they for rectal cancer ? Are they only for cancer that has spread ? What other restrictions are there as to why a patient couldn't have them ? Does it matter if the cancer is in soft tissue ? 

       I just don't get it unless I am wrong my dad's oncologist should be targetting his mutation but yet if my dad's biopsy comes back positive he only wants to use folfiri no targeted drugs . I plan to call the oncologist tomorrow but usually he just tells me he doesn't want to talk about it until the biopsy comes back so I don't think he's going to explain . Also have a phone appointment wiht a second opinion oncologist tomorrow just looking for some info before that thanks . 

 

Updated - Meant with my dad's surgeon and she is really pushing my dad towards radiation as it is " cureable " with it . However it is to the same spot as the last radiation however now my dad has no prostate or bladder there and there is a Omentum flap she used as a kind of wall to hold back my dad's small intestine . Anyone have experience with this issue or having radiation to the same spot twice . Any advice about this would be very helpful as well thanks in advance . 

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  • Tueffel
    Tueffel Member Posts: 327 Member
    #2
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    To give an answer

    To give an answer to your questions, I always have to do a quick research. 

    So PARP inhibitors are used in breast and ovarian cancers especially if the reason for this cancer is the BRCA mutation.

    Your dad needs to be tested if the tumor he has is BRCA mutated with next genome sequencing. If the tumor has the mutation then you can add it to chemo according to my source which is unfortunately in German. 

    I thunk Avastin/Bevacizumab might be an option cause it is 2nd line treatment with Folfiri. 

    Do you know if your fathers tumor is BRAF, RAS or MMR mutated yet? I recently read a study from 2018 I think were only 50% of the tested hospitals do that testing which I think is quite low. But definetely ask why your dad cannot have targeted therapy/ monoclonal antibodies?

    Tueffel

  • worriedson714
    worriedson714 Member Posts: 333 Member
    #3
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    Tueffel said:

    To give an answer

    To give an answer to your questions, I always have to do a quick research. 

    So PARP inhibitors are used in breast and ovarian cancers especially if the reason for this cancer is the BRCA mutation.

    Your dad needs to be tested if the tumor he has is BRCA mutated with next genome sequencing. If the tumor has the mutation then you can add it to chemo according to my source which is unfortunately in German. 

    I thunk Avastin/Bevacizumab might be an option cause it is 2nd line treatment with Folfiri. 

    Do you know if your fathers tumor is BRAF, RAS or MMR mutated yet? I recently read a study from 2018 I think were only 50% of the tested hospitals do that testing which I think is quite low. But definetely ask why your dad cannot have targeted therapy/ monoclonal antibodies?

    Tueffel

    2nd opinion

          The second opinion oncologist just told me foundation one testing showed my dad has BRCA mutation and PARP inhibitors have just started being used in CRC so they would look at that . He also said the foundation one testing shows a mutation in the PK something gene so they would look at that to . He didn't mention BRAF RAS or MMR so I don't think he has those I need to get a copy of the foundation one test . That's what I thought why not avastin will folfiri I am for sure going to be asking more about that . Both oncologist seem to really be pushing more for radiation saying it can cure the cancer . 

  • abita
    abita Member Posts: 1,152 Member
    edited May 2021 #4
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    I get the frustration with

    I get the frustration with them not giving possible scenarios for the various results that could come back. I like to know all the possibilties and as a group, onologists seem to want to know what they are dealing with before giving the scenarios. I do understand why they do it, but I like to play it all in my head, so waiting is not easy for me to do.

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