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P53 Positive

sun1970king
Posts: 5
Joined: Feb 2020

I met with my oncologist today and she was a little confused by my pathology report. It said I had endometrioid adenocarcinoma grade 3, but it also said I was p53 positive. She said those two things usually don't go together. p53 positive typically goes with serous carcinoma. Furthermore, it is usually with postmenopausal women, which I don't believe that I am. Anyone know anything about this? Thank you in advance if you do.

Denise66
Posts: 74
Joined: Aug 2018

What percentage was the P53?  That makes a big difference. P53 was seen in less than 2% of my tumor. I was told by the pathologist that anything less than 5% was negative. I had a grade 2 tumor. You will need to find out the percentage of P53.  That is very important. What stage were you?  You could send your tumor to Sloane Kettering for a second opinion. 

 

 

sun1970king
Posts: 5
Joined: Feb 2020

I have not had surgery yet. This is the original report from the sample they took at my gynecologist's office. Should I not freak out until I have the pathology report from post-surgery?

sun1970king
Posts: 5
Joined: Feb 2020

My surgery is scheduled for the 27th.

Denise66
Posts: 74
Joined: Aug 2018

Please don’t get upset.  The pathologist needs to examine the cells. You do not have hardly any information at this point.  have they done a CT?  

 

 

sun1970king
Posts: 5
Joined: Feb 2020

They did it yesterday and will call me with the results on Monday. My oncologist is also having her pathologist look over my original slides.

Forherself's picture
Forherself
Posts: 503
Joined: Jan 2019

I have read quite a bit about pathollogy.  My first pathololgy changed when I was referred so I also tried to understand why.   And what I have read over and over is that pathololgy for uterine cancer is difficult.  And some slides will be graded differently by different pathologists.  They look at many characteristics of the cells.  Each case of endometrial cancer is different.  There are pathology papers that deal with these difficult slides.  And P53 is an immunohistochemical test.  I think all the characteristis can appear in both types of cancer.  Your oncologist can request that someone else look at the slides for a second opinion.   But it is quite possible that the current pathology is correct, just not the usual picture.  We all say we are a statistic of one.

MAbound
Posts: 1104
Joined: Jun 2016

Hi, "Sunny"!

Welcome to the club that nobody wants to be a part of. Your cancer diagnosis is just a part of the journey you really have no choice but to embark on and there is so much you are going to need to learn for the decisions that are coming down the pike for you.

First of all, this is going to be a potentially long process that will take up the better part of a year to get through. I was diagnosed with the same type and grade of uterine cancer (there is more than one kind) March 18 of 2016 and didn't finish treatment (testing, surgery, recovery, chemo, and radiation) until about Christmas that year and it took a bit longer beyond radiation to recover from that. So prepare yourself for the reality that you are going to need some help getting through some ups and downs this year. You'll be able to live your life between low points, but you will have times where you will be almost too tired to sit up in a chair.

It's all pretty overwhelming and frightening in the beginning because it is all in front of you and so unexpected. If that gives you trouble coping or sleeping, be sure to ask for an anti-anxiety med. Your doctor will understand and there is no shame in it. It's really important to eat and sleep to be able to get through it all. 

The other thing to keep in mind is that this is all a one-step-at-time process. Focus on the current step or prepare for the next, but don't get ahead of yourself because there are so many variables involved with fighting this particular cancer that it's not helpful at all to needlessly scare yourself with statistics or other peoples experiences that probably wouldn't end up applying to your circumstances anyway. We are all unique in what we bring to this journey and the experience is usually different for each of us, but we all have found that it is very doable.

This is a slow growing cancer and the most treatable iteration of it, so there is time to get through further testing and appointments that will precede surgery and to recover from it before anything else. There can be no treatment plan until surgery removes all tissue to stage your cancer and determine other factors that influence treatment options. Use the time to keep learning, ask questions like you are doing, and arrange what you need to in your life so you can focus on yourself when you need to. This is the time to cook and clean so that the dust bunnies don't upset you and the family can fend for themselves.

You've gotten your diagnosis and may have already discussed a hysterctomy with your oncologist. A grade three cancer is more high risk even if it has been caught in early stages, so treatment is likely to be more aggressive than just surgery. Frontline treatment is everyone's best shot for a cure, so this is the time to throw the kitchen sink at it. 

You've come to a really active support group that helps each other get down the road no matter where they are in the process. You are not alone as you face this. There's a lot of practical advice to be found in the threads, so do take time to read through them. We are here to help you with whatever you need whether it's a safe place to vent your feelings, practical advice, or just understanding of what you are going through. 

I'd like to direct you to the My CSN Space so that you can tell us a bit more about yourself and update your journey as things occur. We all have a hard time remembering the particulars about each other and that's the easiest place to go to refresh our memories before responding to each other.

Good luck and always remember you are not alone!

sun1970king
Posts: 5
Joined: Feb 2020

Thank you so much for your responses. I am trying not to get ahead of myself. My surgery is scheduled for the 27th. It will have to be an open surgery because I have a large hernia and some mesh already inside. Thank you again, everyone, for all of your knowledge and support.

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