High Grade Endometrial Stromal Sarcoma (HGESS)

Has anyone diagnosed with HGESS and Stage IVB taken Doxil therapy monthly?  if yes, how did it go?


  • NoTimeForCancer
    NoTimeForCancer Member Posts: 2,999 Member
    jcotton, I am sorry, I cannot

    jcotton, I am sorry, I cannot answer the question you posed simply because I have no experience with either.  I think there are a few women here who have experienced Doxil and you might find some information by doing a search of the content and hopefully those ladies chime in.

    Please let us know how it goes.  

  • Northwoodsgirl
    Northwoodsgirl Member Posts: 571
    edited November 2019 #3


    Treatment of uterine high-grade endometrial stromal sarcoma with apatinib combined with chemotherapy: A case report.

    Zhang Y, et al. Medicine (Baltimore). 2019.


    RATIONALE: The standard treatment for uterine high-grade endometrial stromal sarcoma (HGESS) is chemotherapy after surgery. However, the traditional combination chemotherapy has certain limitation, for example, the cancer cells will quickly become resistant to the chemotherapy drugs. Apatinib is a small-molecule antiangiogenic agent which has shown promising therapeutic effect against diverse tumor, but it still remains unknown whether apatinib has an antitumor effect in patients with endometrial stromal sarcoma (ESS). Here, we report a case of pulmonary metastasis from uterine HGESS successfully treated with apatinib combined with chemotherapy. We also review relevant literature discussing treatment of ESS.

    PATIENTS CONCERNS: A 54-years-old Chinese woman complained of intermittent pain in the waist and abdomen for 4 months. The patient was diagnosed as uterine fibroids before operation. The surgeon performed a total hysterectomy with bilateral salpingo-oophorectomy, resection of peritoneal disseminated lesions, and the pathological examination revealed a HGESS.

    DIAGNOSIS: Uterine HGESS stage IV with lung metastases.

    INTERVENTIONS: The patient underwent surgery, chemotherapy, chemotherapy combined with apatinib, apatinib maintenance therapy, and radioactive particle implantation for lung metastasis.

    OUTCOMES: The patient experienced the above interventions and achieved good results. And continue oral apatinib (500 mg daily) as maintenance therapy. It has been 16 months since the initial diagnosis, and the patient is still in follow-up.

    LESSONS: Apatinib combined with chemotherapy and apatinib monotherapy as maintenance therapy could be a new therapeutic strategy for ESS.


     30921232 [Indexed for MEDLINE]



    Full text

  • Forherself
    Forherself Member Posts: 686 Member
    Welcome Jcotton

    I had the same thought, I can't answer your question.   But welcome.  I do remember one woman who had a ery rare cancer type and someone referred her to a. web group...  I think it was CMB.   Hopefully someone will have some inormation for you.  

  • cmb
    cmb Member Posts: 885 Member

    I have a different type of cancer (uterine carcinosarcoma or MMMT). My front line treatment consisted of four different chemo drugs. The first four cycles were Paclitaxel/Carboplatin, followed by four cycles of Ifosfamide/Adriamycin.

    The Adriamycin that I had is the older from of Doxorubicin, versus the newer Doxil. I did have worse side effects with Ifosfamide/Adriamycin, but I can't say which of the two (or both) caused the problems. However, I have not suffered any long-term effects from chemo, except for some mild neuropathy in my toes (which I attribute to the Paclitaxel/Carboplatin) and most recently some lymphadema in my legs.

    I was staged as 3B and am still NED after the chemo and external radiation.

    There is a Yahoo group for women with MMMT, which I've referenced in other posts, but I'm sorry that I'm not familiar with one that is specific to HGESS.