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New clinical trial from The University of Colorado Cancer Center

BluebirdOne's picture
BluebirdOne
Posts: 191
Joined: Jul 2018

Endometrial cancer clinical trial aims to pave the way for practice-changing therapy

https://coloradocancerblogs.org/endometrial-cancer-clinical-trial-aims-to-pave-the-way-for-practice-changing-therapy/

“We are excited to be one of the first cancer centers in the nation to offer this therapy to our patients,” says Bradley Corr, MD, assistant professor on the gynecologic oncology team at the CU Cancer Center.

Corr developed this trial in collaboration with Clovis Oncology.  CU Cancer Center will be the primary site, Additionally, this trial will be nationally enrolling patients at two other institutions; The University of Pennsylvania and Fox Chase Cancer Center. 

“The Phase II clinical trial aims to determine the effectiveness of the anti-cancer drug Rucaparib as maintenance therapy for patients with metastatic or recurrent endometrial cancer that have been treated initially with chemotherapy,” explains Corr. “Very basically, Rucaparib, a PARP inhibitor, works by stopping cancer cells from repairing their DNA appropriately.  Cancer cells can hijack the body’s system to repair their own DNA, which allows them to multiply. Without the ability to repair damaged DNA, the cancer cells eventually die. Rucaparib is an FDA- approved oral drug used in other cancer types and has been well studied.”

Currently PARP inhibitors are utilized mostly in BRCA ovarian cancer patients, with outstanding sucess. However, preclinical data has demonstrated that patients with a PTEN deficiency may respond to PARP inhibitors as if they had a BRCA mutation.  The PTEN mutation is found in over 80% of endometrial cancer.  This trial will be one of the first to use this drug class in endometrial cancer.  

 

Sounds very promising. 

derMaus's picture
derMaus
Posts: 552
Joined: Nov 2016

Thank you for posting. I hadn't seen this yet, it's very hopeful.

zsazsa1
Posts: 288
Joined: Oct 2018

Wow!  That's great news!

TeddyandBears_Mom's picture
TeddyandBears_Mom
Posts: 1504
Joined: Jun 2015

Thanks for sharing.... What great news for all of us!

Love and Hugs,

Cindi

BluebirdOne's picture
BluebirdOne
Posts: 191
Joined: Jul 2018

with the CU doctors and have nothing but great things to say about them. Since I used to live in Colorado half time I seriously considered getting some of my treatment there and the Mayo people were very comfortable with them.  Luckly, I did not need them due to being 1a and now NED. They are the only NCI designated facility for many states. This was really exciting for me to read that they have a new trial that could help anyone of us now or down the road, especially with the accessibility to the eastern US. If we can help even one of us to get enrolled it is worth the effort and also under scores the fact that treatment options besides chemo and radiation are continuing to expand. 

evolo58
Posts: 293
Joined: Dec 2017

the risk of leukemia. Granted, it happened in fewer than 2% of patients, and granted, ALL treatment drugs have risks, but that risk scares me. For Pete's sake, I have a mutation that only 1% of all cancer patients have! 

BluebirdOne's picture
BluebirdOne
Posts: 191
Joined: Jul 2018

It will be interesting to see how this trial goes. 

Denise 

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