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signet ring cell cancer in colon

Posts: 1
Joined: May 2019

I am new to this site. My 30 yr old son was diagnosed with colon cancer

in Jan. The tumor he had was an unusual one in that this type of tumor

generally appears in stomach or liver, not in colon. Does anyone have

any information on signet ring cell cancer? Thank you

Trubrit's picture
Posts: 4777
Joined: Jan 2013

I would be devestated if he were diagnosed. 

We have had members with Signet ring Cell Cancer and I hope that someone will come along soon to give you the help and advice you need. 

I just wanted to welcome you to the forum, and wish your son well as he moves forward with this terrible disease. 


Butt's picture
Posts: 288
Joined: May 2018

It is very rear and aggressive. You want to consider a large cancer center where they gave more experience. Butt.

Posts: 17
Joined: Jun 2019

Do you know what stage it is? Specifically if there was any nodes involved. They stage cancer by TNM (tumor, nodes, and mets). Signet generally produces mucin, and if found early has generally a good prognosis,  but the mucin can make it easier to spread. Knowing where it was, as well as the RNM will help you get as much helpful information as possible. Only look up scholarly journals, as will as studies from NIH to have reliable info.



marbleotis's picture
Posts: 696
Joined: Mar 2012

Hi and sorry that you are here.

I had stage 3b signet cell colon cancer and was dx'ed at 49 years old.

I have been NED (No Evidence of Disease) for  7 1/2 years.

I had the surgery to remove the tumor and 12 rounds of 5fu and oxi.

I was told that "signet cell" is rare and agressive.  Well I thought cancer is in general rare and agressive.  I focussed on getting through the infusions, went organic, have a consistant exercise plan, added yoga and here I am 7 1/2 years NED.


I am heartbroken about your son.  My story had a twist, after I become NED my son in law had some issues (pain, bleeding...) had a colonoscopy and he was dx'ed with stage 4 rectal cancer with mets to liver/lungs - at 28.  So my happiness for myself quickly changed to big concerns over him.  He is in infusion for 3 1/2 years now and will be on chemo for the long term - he is working the plan!

My advise is get the best Drs and don't be shy about asking questions.  If you are not comfortable - get second opinions.  Your son needs to feel comfortable with your Onc choice.  Best of luck.  You can IM me if you like.

Posts: 2
Joined: Jun 2019

Hi Marbleotis, my Dad just got diagnosed with stage 3 colon cancer, and his biopsy showed signet ring cells. They removed that portion of his colon and now he has a meeting with an oncologist at Wash U in St Louis. He is a very young 70 and extremely fit so he is recovering quickly from surgery. Do you know of any hospitals or oncologists who specialize in signet ring cells? His tumor had high microstatic instability, so it should respond well to chemo despite the SRCs. Or at least, we think. He did have 3 positive lymph nodes and a tumor deposit. It's so encouraging that you also had stage 3 and that you are NED after 7 years! I would love to hear more about where you received your treatment.



Posts: 2
Joined: Jun 2019

GayleGailGale, What stage does your son have? I'm very sorry to hear about his diagnosis bc he is so young. Was he symptomatic? 


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