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There's always something new on the horizon

SandiaBuddy's picture
SandiaBuddy
Posts: 841
Joined: Apr 2017

I came accross this article about the potential of ultrasound to treat colorectal metastises.  I post not suggesting this is a viable treatment, but just to suggest that there are hundreds of treatments under examination and perhaps buying a few extra years of survival will help us to see new and hopefully better treatments.  Cheers.

https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/2211-5463.12642

Metastasis is the primary contributor to colorectal cancer mortality. High‐intensity focused ultrasound (HIFU) is an emerging technology for tumor therapy, which exerts its effects through tumor ablation, mechanical disruption, and enhancement of immune responses. . .  Here, we examined the effect of HIFU on tumor metastasis of colorectal cancer cells and the underlying mechanisms. HIFU was observed to inhibit migration of HCT‐116 cells in vitro and suppress lung metastasis in a mouse model of colon cancer. In addition, HIFU upregulated miR‐124 expression, which inhibited the activation of STAT3 and inhibited migration of HCT‐116 cells. Treatment with an inhibitor of MiR‐124 reversed the effect of HIFU on cell migration. In conclusion, our results suggest that HIFU exerts anti‐metastatic effects in colon cancer, and this effect is possibly mediated via upregulation of miR‐124 and subsequent miR‐124‐mediated STAT3 suppression.

myAZmountain's picture
myAZmountain
Posts: 241
Joined: Apr 2018

Do happen! Am hoping for some breakthrough in near future! Thanks for posting, and for all of your informative posts!

abita's picture
abita
Posts: 579
Joined: Dec 2017

I believe that one day there will be a cure for me. I have to hold on til then.

JanJan63's picture
JanJan63
Posts: 2482
Joined: Sep 2014

Thanks for sharing that! So often what works on a mouse doesn't transwer to humans but one of these days someone's got to make another breakthrough. I want to see it in my lifetime, even if it's too late for me. I want to die knowing that nobody else will die of this.

Jan

beaumontdave's picture
beaumontdave
Posts: 963
Joined: Aug 2013

One step closer, even when the experiments fail, it focuses the efforts.............................................Dave

myAZmountain's picture
myAZmountain
Posts: 241
Joined: Apr 2018
SandiaBuddy's picture
SandiaBuddy
Posts: 841
Joined: Apr 2017

Well, at least we have all seen the man on the moon part.  Mortality is inevitable, but it would be nice to get this cancer issue out of the way.  Hopefully the researchers and pharmaceutical companies will work it out one of these days.  Hopefully we will live to see that day.

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