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Does anyone know anything about this?

Posts: 710
Joined: Jan 2017

it could be the magic bullet for lymphoma. Israelis suffer a much higher rate of b-cell lymphomas than most others so they are motivated to find a cure. I am checking into trials Via friend in Tel Aviv.




Posts: 710
Joined: Jan 2017

A new treatment for non-Hodgkins lymphoma, a cancer of the circulatory system, has passed its Phase II clinical trial.

The good news was announced by CureTech, a portfolio subsidiary of Teva, which holds 33 percent of CureTech, and Clal Biotechnology Industries. Teva has the option of purchasing all the shares.

The treatment, CT-011, is an investigational anti-PD-1 monoclonal antibody – a humanized monoclonal antibody that modulates the immune response and inhibits tumor growth and the spread of metastases. It interacts with PD-1 (Programmed Death-1), an inhibitory receptor belonging to the B7-receptor family that is expressed on lymphocytes and myeloid cells.

PD-1 and its ligand, PD-L1, have been shown to play a central role in tumor recurrence and progression. The presence of these molecules on different tumors, including lymphomas, colorectal carcinoma, renal cell carcinoma and others, has been associated with poor prognosis.

Preliminary analyses indicate that 70 percent of the patients treated with CT-011 were progression-free at the end of the follow-up period, as compared to only 47 percent in the historical control. Furthermore, 84 percent of the patients treated with CT-011 were alive by the end of the follow-up period, compared to only 62 percent in the historical control.

“We are very pleased to have achieved this major milestone in the clinical development of CT-011,” said Dr. Michael Schickler, CEO of CureTech.

So far, researchers say CT-011 has enabled patients with Diffuse Large B Cell Lymphoma (DLBCL) to reach a primary endpoint of improved progression-free survival (PFS) following autologous stem cell transplantation. In addition, statistically significant results were achieved in the secondary endpoint of Overall Survival (OS).

“DLBCL is an aggressive type of non-Hodgkin's Lymphoma (NHL) affecting about 40% of all NHL patients," said Jacob M. Rowe MD, Director, Department of Hematology, Shaare Zedek Medical Center in Jerusalem, Israel. “I am very encouraged by the results of this trial and am certain that if these results will be confirmed in future controlled Phase III studies, CT-011, a truly novel anti cancer therapy will improve the lives of many DLBCL patients.”


“The results of this early study are exciting,” said Arnon Nagler, MD, Director of the Division of Hematology, BMT and CBB at the Chaim Sheba Medical Center, Israel and co-International Principal Investigator in the study. “There is a significant unmet medical need for therapies that could benefit these patients and I am pleased that such a promising treatment came out of Israeli science. http://www.israelnationalnews.com/News/News.aspx/144511#.Tr_acPQr27s

Max Former Hodg...
Posts: 3699
Joined: May 2012

Shady, I have been hearing about major cancer research announcements to be made in Israel for a few weeks now. I don't know a lot of particulars yet, except that it is supposidly a new modality: not quite Car-T or chemo.  This article of course referrs to a new monoclonal.

Evarista's picture
Posts: 320
Joined: May 2017

This looks much more promising than some others I have seen recently.  The published Phase I/II clinical trial numbers in MM were small (15 patients) but the results were promising. They were published in 2014 and 2015 in respectable journals (Blood and J. Haematology).  They may have more data that has not been published, but their website does not indicate that, so hard to know. Abstract for the 2nd publication:   https://www.ncbi.nlm.nih.gov/pubmed/25496030

I think sometimes these hyped-up announcements are for the purpose of raising venture capital (Phase III's are mega-costly).  Not saying that that is necessarily the case here. Will be keeping an eye on their progress.

Posts: 710
Joined: Jan 2017

Is very interesting. The monoclonal not so much. The hype is always a big issue. Really can’t count on the news flashes because so many of these research groups are fishing for grants. Still it bears watching. I really do expect some major breakthroughs soon. They will not necessarily be made in the USA. I wish I was as knowledgeable and as articulate as Evarista.

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