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Why the liver?

SandiaBuddy's picture
SandiaBuddy
Posts: 892
Joined: Apr 2017

Liver metasteses are a frequently discussed topic on this forum.  My surgeon says if I have a recurrence it is about a 66% chance it will be in the liver.  I found this recent abstract (I cannot get the full article) both troubling and interesting:

https://academic.oup.com/carcin/advance-article-abstract/doi/10.1093/carcin/bgy115/5090278

Liver metastases develop in more than half of patients with colorectal cancer (CRC) and are associated with a poor prognosis. The factors influencing liver metastasis of CRC are poorly characterized, but this information is urgently needed. We have now discovered that small extracellular vesicles (sEVs, exosomes) derived from CRC can be specifically targeted to liver tissue. . .

Another:

https://www.ajmc.com/journals/supplement/2018/managing-evolving-landscape-colorectal-cancer/evolution-biomarkers-guide-treatment-metastatic-colorectal-cancer

Approximately 50% to 60% of patients with CRC develop metastatic CRC (mCRC), and 80% to 90% will have unresectable liver metastases.

mountainhiker
Posts: 54
Joined: Aug 2018

Liver first, lungs second, after that it's anyone's guess.

BGNor's picture
BGNor
Posts: 28
Joined: Feb 2018

Depends on the location of the primary cancer I believe. Rectal cancer is more prone to metastase til lungs.

I had rectal cancer, now got 9 lung mets. Liver is OK - so far.

darcher's picture
darcher
Posts: 257
Joined: Jun 2017

  The lymph nodes go to the liver from the colon and rectum. Theyre the first thing infected with cancer cells outside the colon itself.  That's what I was told and even though mine were clean they still made me do 4 months of chemo.  I'm glad they did since who knows how many cells it takes to start up a new tumor.  

beaumontdave's picture
beaumontdave
Posts: 996
Joined: Aug 2013

My onc. was very succinct about it, said "it's just the next stop". I was good with that answer, lol..........................................Dave

Kazenmax's picture
Kazenmax
Posts: 355
Joined: Feb 2016

It also depends on where the tumor is located. My cancer came back in my left lung. My doctor said there's lots of blood vessels in the area of my tumor (very low, close to sphincter). He figures microscopic cells got through.

K

SandiaBuddy's picture
SandiaBuddy
Posts: 892
Joined: Apr 2017

Ugh!  These cavalier statistics they throw into academic articles are certainly worrisome.  I guess the only answer is to live life to its fullest every day.

beaumontdave's picture
beaumontdave
Posts: 996
Joined: Aug 2013

I'm glad I didn't read those tidbits early on, they sound worse than the odds I did read, and they're one more reason to tell my story and say " here I am". 

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