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Grapefruit juice?

Posts: 41
Joined: May 2018

Anybody have a bad reaction to grapefruit juice after starting immunotherapy?

Manufred's picture
Posts: 241
Joined: May 2017

Never tried it - always heard that grapefruit juce can enhance the action of many medicines.

Posts: 68
Joined: Oct 2013

Good Morning, Jeffris!

Grapefruit juice interacts unfavorably with a number of medications.  I don't know about immunotherapy, but my husband is on Sutent and the doctors, as well as documentattion from the Pfizer cautioned against mixing the two.  As Manufred said, it can enhance the effect of some meds.  I would check with your doctor.

For what it's worth, which may not be more than a penny, I recently read on another board that pomegranete and Seville oranges (used in some marmaldes) can cause similar reactions.

todd121's picture
Posts: 1449
Joined: Dec 2012

It messes with an enzyme in the liver that is used for about 50% of drug metabolization. It can cause you to either metabolize the drug too slowly or too quickly depending on the drug (as I understand it). The enzyme is CYP3A4. You should check the drug(s) you are taking whether or not it's ok to drink grapefruit juice with the drug you're taking. Some other citrus also affects this enzyme.

You should also be very careful about your antiacid usage with your drugs. Lowering stomach acid can change how you digest the pills you are taking. If you want to be careful talk to your pharmacist or doctor about these interactions. I've seen some suggestions on when to take antiacids relative to certain medications. You also have to consider the type of antiacid. They work in different ways.


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