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Autoimmune Hemolytic Anemia

Lauraisabel
Posts: 54
Joined: Jun 2017

Hi there, I found out that I'm severely anemic. I'm having a bonemarrow biopsy,with a rituxin infusion. Has anyone had this i and how did it go?

I also. Have MZL....have been on w/w this whole time...but feel really tired all the time. I am so thankfu for all of you because I learn a lot by reading your experience. You are all heroes!

Thank you for any feedback.

Laura.

 

Lauraisabel
Posts: 54
Joined: Jun 2017

Hi there...is there a way that I can send you a copy of report?

laura

po18guy
Posts: 1101
Joined: Nov 2011

You can post up some of the info, but reading and interpreting reports is far from my strong suit - if I even have one! Your best bet is still to have the biopsy sample (all recent examples, if available) sent to Moffitt/MD Anderson/Memorial Sloan Kettering or another world class facility for more sophisiticated pathology and diagnostics. As you are well aware, lymphoma can be diabolically dificult to properly identify.

Lauraisabel
Posts: 54
Joined: Jun 2017

Interpretation.... there are mixed b and T cells of uncertain significance.

There is a significant number of nodular and well circumscribed lymphoid aggregates comprised of small lymphoid cells with dense chromatin ....the aggregates are comprised of mixed B and T cells with an overall T cell predominance.

po18guy
Posts: 1101
Joined: Nov 2011

The presence of T-Cells, especially thier predominance, seems to indicate that something unexplained is occurring. T-Cells, in particular, normally migrate from the marrow to the thymus, where they receive their education and then flow into blood and lymph for immune system duty. If the T lymphocytes are immature, it might mean an over production in the marrow. If they are mature, post-thymic T lymphocytes, then they have migrated to the marrow for some reason.

There is no mention of FISH or Flow Cytometry done on the sample. Without that information, it is basically impossible to determine if they are performing some immune function, or are replicating themselves in a malignant process. Thus, they need to go to the lab for further workup. You have been fighting this for some time. MZL is an indolent, chronic lymphoma, and one lives with it. However, the marrow aspirate is unusual enough that it warrants further investigation, IMO.

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