Anyone have experience with OPDIVO?

welcome to the club that no one wants to belong to.  This is a good place to come. Wonderful ladies.  I am not on Opdiv, but another immunotherapy drug called Keytruda.  I will be getting my 9th infusion tomorrow.  My oncologist choose Keytruda instead of Opdivo because Keytruda is given every three weeks and Opdivo every two.  They are very similar.  So far I have had very few side effects and most of the time I feel better than I have for a very long time.  Immunotherapy is different from chemo in a number of ways.  The first CT scan showed shrinkage everywhere, the second everything remained the same, except for one nasty tumor in my neck that grew.  It grew over some nerves and was causing a lot of pain so I just finished ten radiation treatments.  I am not disappointed with how Things are going and neither is my oncologist.  It has given me over six months of pretty high quality life that I wasn't expecting to have..  

Hugs and prayers, Lou Ann

I also visited with Dr. Chon last November for a second opinion after carbo/taxol did not work for me. CT/PET scans showed growth throughout pelvic and stomach lymph nodes, perioneatal lining and omentum. She recommended doxil + avastin and I will do third cycle this week. I have been told Keytruda is not an option for me because I do not show a PD-L1 receptor on the Caris molecular intelligence report. So I was wondering Ocalagal if you used any kind of molecular analysis to determine that Opdivo was potentially a good fit for you. I was told by onc there is a risk that if certain receptors are not present, these treatments can actually have a high risk of harming your organs. For the others who have used doxil, what has been the outcome for you all?  Doesn't sound very promising and that I may be "researching" next treatments again come May. Any instances of "success" with doxil from this board?  And like the others very interested in experiences with Opdivo. Also to continue to share what recommendations we Floridians are getting from Moffitt.  K   

I posted this interest under the recent Opdivo stream but thought I would pull it out as a separate discussion for those of us in Florida using Moffitt. I too saw Dr Chon for a second opinion last November and plan to continue to use Moffitt for consults since I am a Floridian. After carbo/taxol did not work for me (stage 3 UPSC) Dr. Chon recommended Doxil + avastin 28 day cycle for doxil and 15 for avastin and I will do third cycle this week. Reading the posts, I gather I should not be surprised if doxil is not the answer and come May I may be considering what next? I wondered if any of you ladies using Moffitt have looked at their clinical trials? Do you all have any good experiences with other chemos besides carbo/taxol or doxil?  K

I have restage Lung cancer metastasized into bones. Last week I received my 41st dose of Opdivo. (I had already had 1round radiation & 2 rounds chemo for primary non small cell lung cancer). I wouldn't survive a 3rd round of Taxol based chemo so my Onc. ( who helped invent Opdivo) suggested Opdivo. I have yet to show any side effects that are negative. I have energy stamina etc. All scans since starting Opdivo have shown significant shrinking of restage cancer. I'm pleased with the results so far. Please remember that everybody's bodies are different so results vary with Opdivo treatment.