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VEGF Inhibitor

Tethys41's picture
Posts: 1248
Joined: Sep 2010

Avastin works as a VEGF inhibitor.  Elevated VEGF results in angiogenesis, excessive production of new blood vessels, allowing new blood vessels to develop and feed a tumor.  A tumor cannot grow larger than 2 mm, without a blood supply.  This research indicates that Grape Seed Extract is also a VEGF inhibitor:


Alexandra's picture
Posts: 1311
Joined: Jul 2012


Avastin (Bevacisumab) is one of the most expensive drugs, ranked #16 in sales. In 2012 Avastin sales were Billion $2.56. In the U.S. insurance companies have refused to pay for all or part of the costs of bevacizumab, and in countries with national health care systems, such as the UK and Canada, the health care systems have restricted its use because of the low ratio of benefits to cost. In Canada it is reported to cost $40,000 CAD per year.

Who would kill this cash cow in favor of grape seed extract?

Date Range Sales Rank Sales ($000)   Units (000)  
Q1 2013 16 1.04%
Q4 2012 16 -2.49% -2.12%
Q3 2012 16 (2) 0.41% -0.84%
Q2 2012 18 (2) 2.46% 3.48%
Q1 2012 20 (1) -1.92% -2.13%

I suspect that very old (1920) Johanna Brandt Grape Diet (12 hours of fasting, followed by 12 hours where you consume absolutely nothing except purple Concord grapes (and/or grape juice) with skins and seeds, worked among other reasons because of VEGF inhibition. http://www.cancertutor.com/Cancer/GrapeCure.html

Artemisia annua (Chinese wormwood), Viscum album (European mistletoe), Curcuma longa (curcumin), Scutellaria baicalensis (Chinese skullcap), resveratrol and proanthocyanidin (grape seed extract), Magnolia officinalis (Chinese magnolia tree), Camellia sinensis (green tea), Ginkgo biloba, quercetin, Poria cocos, Zingiber officinalis (ginger), Panax ginseng, Rabdosia rubescens hora (Rabdosia), and Chinese destagnation herbs.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891166/ part 1

http://www.ncbi.nlm.nih.gov/pubmed/17576449 part 2

Here's an interesting article from China on Marine-Derived Angiogenesis Inhibitors for Cancer Therapy http://www.mdpi.com/1660-3397/11/3/903   

and research from India rspublication.com/ijst/june12/18.pdf

and from Brazil https://www.sigaa.ufs.br/sigaa/verProducao?idProducao=51003&key=e41f549f3b86de2252ac856e4ccbd067  on natural VEGF inhibitors to treat cancer.

poopergirl14052's picture
Posts: 1185
Joined: Nov 2010

For the research you share..very informative. ..Val 

Posts: 471
Joined: Feb 2011


Your post is really well-informed: valuable to all of us.


I know a woman diagnosed with serous uterine cancer--quite aggressive--who refused chemo and instead did the grape diet you refer to.  Five years later, she is alive and well, with no recurrence.  Admittedly, she was diagnosed at Stage !A or 1B: so her disease hadn't yeat progressed too far.  

Nonetheless, serous tumors usually recur--even with treatment--within three years.


In addition, let's put in a word for apinigen, a great substance in celery and parsley: highly anti-angiogenic.


Rosey R












Tethys41's picture
Posts: 1248
Joined: Sep 2010

It's important not to blindly forge ahead with a treatment such as this.  You do need some level of VEGF to protect your heart.  If you were to take a VEGF inhibitor, when your VEGF is normal, you could drop it too low.  I, personally, take Bindweed extract, under the guidance of my ND, to reduce my VEGF level.  I know that it works for me because when we raise or lower the dosage, my VEGF changes accordingly.

gdpawel's picture
Posts: 538
Joined: May 2001


Good points about VEGF inhibition Tethys. Some French research has found out that very high doses of antioxidant polyphenols can shut down and prevent tumors by cutting off the formation of new blood vessels needed for tumor growth. Polyphenols are commonly found in red wine. However, the amount of polyphenols necessary to obtain an anti-cancer effect in red wine would be the equivalent of drinking about a bottle of it each day. This amount of daily alcohol consumption obviously would be unhealthy, but their research suggested that polyphenols "extracted" from plants or red wine could be converted into a pill that is highly likely to be safe. Such a pill also would be relatively easy and inexpensive to create and deliver.

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