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cimetadine and immunity

vinaykumar
Posts: 66
Joined: Dec 2012

found this rather technical but good study of effects of cimetadin on immunity and dendritic cells

 

http://www.readcube.com/articles/10.1038/sj.bjc.6600233?locale=en

tanstaafl's picture
tanstaafl
Posts: 1292
Joined: Oct 2010

My personal view is that cimetidine works best from the first day of diagnosis for about 2/3rds of the stage IIIs, the biomarked ones most likely to recur, and maybe as much as 3/4ths of the stage IVs.   My wife necrosed much of her initial load in 4 weeks before surgery and did not metastasize after carrying a large  cluster of para aortic lymph nodes for over a year where her tumor tissues were among the strongly CA19-9/CSLEX1 biomarked damned.  

Of course we do a lot of naughty supplement stuff along with her very continuous, light metronomic chemo (3x oral everyday).

LEF recommended type of supplements and generics plus even more vit D3, K2/K3, oral and IV vit C.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

i stopped cimetidine, 6 weeks later cea 23 up from 2.8

i am back onit.

great article.

Chelsea71
Posts: 1170
Joined: Sep 2012

Does anyone take cimetidine while on Irenotecan? Steves oncology pharmacist said it could cause liver toxicity. I haven't come across this as being contraindicated. I don't really trust this pharmacist and am thinking maybe it's worth the risk. Any thoughts?

Sundanceh's picture
Sundanceh
Posts: 4408
Joined: Jun 2009

Morning Chels:)

Check out this link.....I highlighted a couple of things of interest....

http://en.wikipedia.org/wiki/Cimetidine

In Asia, cimetidine, which molecularly targets EGF, VEGF and e-selectin associated with sialylated Lewis biomarkers and metastasis, has been combined with long term, continuous low dose 5FU[10] or metronomic tegafur-uracil chemotherapy for advanced epithelial cancers, with unusually long survival[11] including for stage III colorectal cancers,[12] as well as refractory and recurrent cancers

Adverse effects and interactions[edit]

Cimetidine is a known inhibitor of many isozymes of the cytochrome P450 enzyme system[13] (specifically CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4). This inhibition forms the basis of the numerous drug interactions that occur between cimetidine and other drugs. For example, cimetidine may decrease metabolism of some drugs, such as those used in hormonal contraception. Cimetidine is a competitive antagonist at the dihydrotestosterone (DHT) receptor, leading to exaggerated effects of estrogens. In women, this can lead to galactorrhea, whereas in men, gynecomastia has been reported;[14] during postmarketing surveillance in the 1980s, cases of male sexual dysfunction were also reported.[15][16] Cimetidine also affects the metabolism of methadone, sometimes resulting in higher blood levels and a higher incidence of side effects, and may interact with the antimalarial medication hydroxychloroquine.[17] Cimetidine is also known to potentiate the effects of several opioids which are partially metabolized via the cytochrome P450 pathway via inhibiting their metabolism and a temporary decrease of liver function due to reduced hepatic blood flow. This can lead to extreme plasma levels of these drugs and can easily lead to a fatal overdose.[18]

 

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

so i have been back on cimetidine for a few weeks, my liver enzymes have never been better, so I think when using off label stragegies the buck stops with you, do all your bloods, every week or two. i do, look for anything that seems attributable to cimetidine in this case, I built my extensive routine by adding all the off labls and supplements ovr time, not all at once, that would be two dangerous.

so much you can do for liver detox assistance from mushrooms, milk thistle, dandelion tea, diet, water, exercise, sauna therapy, enemas. all these remove toxins away from the liver, effectively reducing its burden. its all apart of the strategy, its always been the key organ in the survival game. its really resilient, we have to stop the mets from forming, we have to slow the aggressiveness of the tumours growth in this key organ.

strateies that target hif via exercise, and even.

if you go for cimetidine, i tak 400mg morning and night. with every meal I take supplemental enzymes and bentan hci to boost stomach acid. I can live with sexual dysfunction from cimeidine, but we cannot live without amino acids from protien, we need acid for that.

coffee enemas speed the liver detox pathway. so it all seems to be working well for me at present. my CRP just fell back 0.3, it was 7 a week ago. the focused therapies are working. 

strategies for targetting systemic inflamaion is really where the money is at, cimetidine is a simple no brainer. goodluck if you try it, none of this is medical advice, just my experience.

hugs,

pete

ps i just popped 1000mg xeloda, 3 hours before full body hyperthermia, now its nice to think my cimetidine inhibit the clearing of the low dose xeloda, effectively giving me a longer benefit of the chemo. for every interaction we have a risk and a possible benefit. this is just speculation on my part, so far I am alive, as i am typing. 

compared to chemos toxicity, cimetidine is childs play. afterall mcrc is considered terminal

lp1964's picture
lp1964
Posts: 1238
Joined: Jun 2013

Dear Pete,

You mentined full body hyperthermia. What does it do and how do you create hyperthermia?

Thaks,

Laz

Chelsea71
Posts: 1170
Joined: Sep 2012

Thanks for the above info, Craig. I'm really mixed up when it comes to Cimetidine. Steve was taking 1000 mg daily. Ten days into it his ALP went up to almost 400 and he started having fevers. The timing made me suspicious of the cimetidine. If it wasn't for him starting Folfirinox, he would give it another try. We meet the new onc on Friday. Will get his opinion. Like Pete pointed out, it is a pretty serious situation. May be worth taking the risk???

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

goodluck, you need more than cimetidine, i fear.

i suspect the extra long survial craig mentions, is due to the boost to the immune system, i just realised that now i am a low dose xeloda kind of guy, on cimetidine and psk = coriolos i fit the therapy mix that enjoyed long term survival. that made me happy. another clear benedit to leaving the standard of care to the skeptics. if they want its their, those that want first class care well, its easily achievable.

well xeloda, psk, cimetidine mix is a no brainer really, even most oncs would agree, i just realised i am adding avastin to this mix today. now thats geting really exciting.

hugs,

 

vinaykumar
Posts: 66
Joined: Dec 2012

for my dad , i keep the cimetadine to abt 600 mg  for 4 days after oxi infusion and then ramp it up to 1200 day for rest of the days. also i try to give my dad probiotic drinks and space out the cimetadine to 1 hour after food.

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