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Is the night time the right time for 5-FU?
coloCan
Posts: 1956
Joined: Oct 2009
Apr 09, 2013 - 7:14 pm
Is 5-Fu given via a pump to take home for 46 hours done so because during the night time liver enzymes that detoxify the liver are more abundant than during the day thus making the 5-Fu less toxic?-
I was told that 5FU has a very short half-life (something like 10 minutes), so that to ensure that there is some active in your system, it is given in a 46 hours drip.
and given the idea that supposedly 2/3s of the efficacy of FOLFOX is derived from the 5-FU it must be pretty potent yet i always thought it was the oxi that was the stronger
When I was getting 5-fu,it was with a chemo pump delivering 1 1/4 cc Hr 24/7. That lasted all 5 weeks I was getting radiation. 2010 was quite a year, but the resection,ileostomy,and reversal worked! My colonoscopy in 2011 showed NED. Been NED ever since living a normal(?) life.
Joined: Mar 2010
It's because you need the continuous drip of 5FU
I was told that 5FU has a very short half-life (something like 10 minutes), so that to ensure that there is some active in your system, it is given in a 46 hours drip.
Alice
Joined: Oct 2009
i had asked that based on the following article
from last sentence of second paragraph
http://medicalxpress.com/print284730928.html
and given the idea that supposedly 2/3s of the efficacy of FOLFOX is derived from the 5-FU it must be pretty potent yet i always thought it was the oxi that was the stronger
Joined: Jun 2012
Might also be to minimize
Might also be to minimize side effects. I always get a bolus of about 950mg and then like 5000mg for the 46 hours.
Joined: Apr 2012
5-fu
When I was getting 5-fu,it was with a chemo pump delivering 1 1/4 cc Hr 24/7. That lasted all 5 weeks I was getting radiation. 2010 was quite a year, but the resection,ileostomy,and reversal worked! My colonoscopy in 2011 showed NED. Been NED ever since living a normal(?) life.
Joined: Oct 2009
While i've never heard of this and i doubt you have either
i wonder what the astronauts have to say about this "risk"
www.myhealthnewsdaily.com/3711-space-travel-colon-cancer-risk.html
Joined: Jun 2012
I did a
post on circardian rythym and Chemo (here somewhere) , the right time makes a huge difference on effiacy and side effects