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vaccine ... so near and yet so far

alligatorpointer's picture
Posts: 131
Joined: Jul 2012
It is so frustrating to know that vaccines like this are so close to being perfected, yet so far from being available to the patients who so desperately need them: 



French researchers at the Universite Paris Descarte in France have invented a promising new vaccine - administered as a nasal spray - being developed to treat several cancers.

It is one of a growing number of vaccines developed in the last few years to fight cancer that ultimately will eliminate outdated harsh chemotherapies and radiation treatments and use the bodies own natural immune system.

The vaccine has been first tested on head and neck cancers.


When a person develops cancer, the body mounts an immune response against the renegade cells but it is often too weak to halt their spread. So, to supplement radiation and chemotherapy treatment, scientists have been working to develop vaccines to boost the body's natural defenses against the tumors. Two promising vaccines in late-stage human trials target prostate cancer and metastatic melanoma, the deadliest form of skin cancer.

Another vaccine in the pipeline is designed to treat solid tumors that form in the mucosal tissues that line passages in the head, neck, lungs and genitals. The tissues produce a thick lubricating fluid containing powerful chemicals that normally protect against infection. Unfortunately, they also also block the immune cells that would otherwise fight the cancerous tumors. Now researchers have developed a nasal spray vaccine which overcomes this resistance, activating and mobilizing a specific type of immune cell, called a CD8+ T-cell, in the tissue at the tumor site.

Eric Tartour, a researcher with the Universite Paris Descarte, led a team studying the effectiveness of the intranasal spray on solid mucosal tumors in mice.

He says the tumors developed after the mice were infected with a strain of human papilloma virus that's known to cause cancer.

"The tumor shrank," said Tartour. "And we also analyzed the tumors after they shrank. And they were heavily infiltrated by immune cells which destroyed the tumors."

Tartour and colleagues also compared the effectiveness of their vaccine when it was injected, and found it was less potent than when given by nasal spray.

"What we demonstrated in this study is that it is important the way that you administer a vaccine," he said. "It is not only [important] to have a good cancer vaccine. It is also important to have a proper way to administer it."

Tartour says the researchers' next goal is to see how well their intranasal vaccine, which has been five years in development, works against tumors that have metastasized or spread to distant sites in the body.

Eric Tartour and colleagues describe their anti-cancer nasal spray in an article in the journal Science Translational Medicine.




alligatorpointer's picture
Posts: 131
Joined: Jul 2012

According to the article ...
"The vaccine has been first tested on head and neck cancers."

Has anyone else seen information about this vaccine?

Posts: 1914
Joined: May 2012

Hello !

I wanted to respond to this very interesting post.  I know 3/4 or more of us just want our cancers gone, and to move on with life.  I agree to a point.  But this monster keeps rearing it's head and destroying lives daily.  I haven't checked this article out yet, but will.  I'm hooked up with an org. that is international and it is amazing on what other countries are doing with research and tx's, that are unavailable here in the states.  I want to thank you for pointing this one out.  No we are not medical proffessionals....but we are living it daily.  Any and all info. that may make a dent is valuable.   Katie 

Posts: 213
Joined: Feb 2013

Does anyone know if this has had a human trial?  I agree we need info on this deal.

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