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Curcumin clinical trial???

smokeyjoe
Posts: 1428
Joined: Feb 2011

I wish I know how to post a link!!

Phase I Study of Surface-Controlled Water Soluble Curcumin (THERACURMIN CR-011L)
This study is currently recruiting participants.
Verified April 2012 by M.D. Anderson Cancer Center

First Received on September 9, 2010. Last Updated on April 19, 2012 History of Changes
Sponsor: M.D. Anderson Cancer Center
Collaborators: Gateway for Cancer Research
Theravalues, Inc.

Information provided by (Responsible Party): M.D. Anderson Cancer Center
ClinicalTrials.gov Identifier: NCT01201694

Purpose
The goal of this clinical research study is to find the highest tolerable doses of surface-controlled water dispersible curcumin (curcumin) that can be given to patients with advanced cancer. The safety of this drug will also be studied.

Condition Intervention Phase
Advanced Cancers
Drug: Surface-Controlled Water Soluble Curcumin
Drug: Surface-Controlled Water Soluble Curcumin MTD
Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase I Study of Surface-Controlled Water Soluble Curcumin (THERACURMIN CR-011L) in Patients With Advanced Malignancies

steved
Posts: 835
Joined: Apr 2004

Not sure I fancy volunteering to see how much turmuric I can take before I turn yellow!

Strangely there is actually some data on curcuminoids promoting cancer - particularly colon cancer but I assume that is irrelavant in these participants who all have advanced cancer.

steve

jasminsaba
Posts: 157
Joined: Jul 2011

I have never read or come across any data that indicates Curcumin/curcuminoids promote cancer ... all data points to its potential use/benefit in particularly preventing, possibly treating colon cancer.

smokeyjoe
Posts: 1428
Joined: Feb 2011

I haven't seen that they promote cancer either!! Steve can you tell us where you saw that, I'd like to check it out....all I've seen is various good things curcumin is supposed to have a positive effect on.

tanstaafl's picture
tanstaafl
Posts: 1292
Joined: Oct 2010

Potential interactions of curcumin and irinotecan have been mentioned before. One curcumin product warning stated:

"INTERACTIONS/CONTRAINDICATIONS Curcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies. In vitro research revealed that curcumin decreased camptothecin-induced death of cultured breast cancer cells. Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer. The concurrent use of curcumin with these agents should be avoided."

We're not using irinotecan, so we feel comfortable with curcumin.

smokeyjoe
Posts: 1428
Joined: Feb 2011

Thanks Tanstaafl....I've googled curcuminoids promote cancer and came up with nothing....yet....other than these interactions I'd be interested to see any other info. I saw somewhere that it promotes your gallbladder to purge or something....sounded kinda similar to that thing Pete was talking about to get rid of stones.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

MD doing a clinical on turmeric, I don't feel so foolish now,

You know the politex behind these trials, so they look for Max safe dose, let's all enrol, exceptthose contrad out. Thanks tans.

Yellow from turmeric is better that black from dead.

I gotta meditate , that dam rooster woke me again.

My thoughts and prayers are for us all and that we each find hope, health and happiness.

Hugs,
Pete

Ps early to bed, early rise you know the ending.
Pps oh and I bet my life they will find the heavy turmeric cohort last a bit more. I hope so, it's going to be called an observation, while at Max safe dose.

Pps had anyone enrolled, if anyone get the details let me know.
My only critic would be water solvable, when I know they make liposomal that supposed to have much better absorption.

northernlites
Posts: 96
Joined: Jun 2011

Hi all,
Is turmeric the same as curcumin? I am taking turmeric in capsule form

Tessa

neons356
Posts: 58
Joined: Dec 2010

I cook with it a lot. Actually I was using it before I found out a few years ago that it might be good as a preventive for the beast, and perhaps helpful in beating it. I really like it as a spice, especially with chicken, rice, and in macaroni&cheese.

janderson1964
Posts: 2215
Joined: Oct 2011

Curcumin is the active ingrediant in Tumeric that is supposed to be effective in fighting cancer.

Steved I have researched curcumin extensively and haven't read anywhere that it can promote cancer. In fact Johns Hopkins has done several studies on it. There are several hospitals that have been doing trials/studies on it. None with negative results.

Tanstaafl. I am doing Irrinotecan. I told my Oncologist everything I was taking and he didn't see any problem with it including tumeric/curcumin. He specializes in gastrointestinal cancers and is at an NCI hospital so I trust his opinion.

Pete I am seeing more major cancer centers researching natural approaches (MD Anderson, Memorial Sloan Kettering, Johns Hopkins etc.) It seems as though they are coming to thier senses as long as the big drug companies don't try to put an end to it.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

The Japanese have been doing gersin for 15 year's in big hospitals.
Our countries are so slow, alas. Goto sleep now, coffee at 4.30am before exercise

Soon they might do a clinical trial on water, maybe even oxygen.

Hugs,
Pete

smokeyjoe
Posts: 1428
Joined: Feb 2011

Pete my mind wanders to strange places every time I see the word "coffee" in your posts :) Sorry Bud, just sayin.....

Tans....after I saw your post on turmeric and drug interactions I started to do a search, and came up with one for cimetidine and turmeric...I believe it was on Livestrong...I think basically because turmeric can cause more acid in your stomach. But, I found that interesting.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

Getting our livers to function well is the goal of gersin, the diet and the treatments.
It's also why I dropped cimetidine and why too much turmeric to the point of stomach irritation is a concern.

We need knuffer liver cells working.

Hugs,
Pete

Ps I'll stop joking about my coffee.
I'm just glad you did this great little post about turmeric.

smokeyjoe
Posts: 1428
Joined: Feb 2011

Oh no Pete don't stop joking 'bout it.....I didn't mean it that way....just if you ever invite me to meet for a coffee I won't know how to take that :)

steved
Posts: 835
Joined: Apr 2004

I am not an expert in the use of a lot of the alternative/ complementary therapies as I haven't really engaged with them personally. However, my reading around curcumin is that it is one of the more widely used complementary treatments and does have some evidence of anticarcinogenic effets mainly from in vitro (test tube) and animal studies- no randomised human studies I am aware of. The theory mainly is that it promotes apoptosis (cell death) in cancer cells and leaves helathy cells unaffected.

However I am also aware of a few studies that suggest carcinogenic effects:

Kawanishi et al. remarked that curcumin, like many antioxidants, can be a "double-edged sword" where, in the test tube, carcinogenic and pro-oxidant effects may be seen in addition to anticancer and antioxidant effects.[46] Carcinogenic effects are inferred from interference with the p53 tumor suppressor pathway, an important factor in human colon cancer.[47] In vitro and in vivo studies suggest that curcumin can have carcinogenic effects.[48][49][50]

The quoted studies for those really interested are:

46.^ Kawanishi, S.; Oikawa, S.; Murata, M. (2005). "Evaluation for safety of antioxidant chemopreventive agents". Antioxidants & Redox Signaling 7 (11–12): 1728–1739.
47.^ Moos, P. J.; Edes, K.; Mullally, J. E.; Fitzpatrick, F. A. (2004). "Curcumin impairs tumor suppressor p53 function in colon cancer cells". Carcinogenesis 25 (9): 1611–1617. 48.^ a b Burgos-Moron, E.; Calderón-Montaño, J. M.; Salvador, J.; Robles, A.; López-Lázaro, M. (2010). "The dark side of curcumin" (pdf). International Journal of Cancer 126 (7): 1771–1775.
49.^ Dance-Barnes, S. T. (2009). "Lung tumor promotion by curcumin". Carcinogenesis 30 (6): 1016–1023. doi:10.1093/carcin/bgp082. . PMID 19359593.
50.^ López-Lázaro, M.; Kock, N. D.; Moore, J. E.; Lin, E. Y.; Mosley, L. J.; d'Agostino, R. B.; McCoy, T. P.; Townsend, A. J. et al (2008). "Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent". Molecular Nutrition and Food Research 52 (Supplement 1): S103–S127. doi:10.1002/mnfr.200700238. PMID 18496811.

Personally I support the idea of robust trials truly investigating many of these treatments in the same ways that medicines are as I am sure some genuinely do have value and others do nothing, while some potentially can do harm- at present we don't have the knowledge to know which are which and this trial is a step in the right direction.

steve

smokeyjoe
Posts: 1428
Joined: Feb 2011

SteveD, thanks, interesting.

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