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Pete I think you'll find this clinical trial of interest

smokeyjoe
Posts: 1428
Joined: Feb 2011

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Feasibility Clinical Study of Targeted and Genome-Wide Sequencing

SummaryTrial DetailsEligibilityCentres / ContactsOfficial Title
Feasibility Clinical Study of Targeted and Genome-Wide Sequencing

Summary:
This research is being done to find out what types of gene mutations are present in people with cancer. This study is designed to help researchers and doctors understand more about cancer. With this information, doctors may have a better idea as to which cancer treatments are most appropriate for certain patients. The information will also help researchers find out the how to identify genes in cancers from biopsies and blood samples and how to use this information to help doctors and patients make treatment decisions.

Trial Description
Primary Outcome:

•Time from patient recruitment to final results ≤ 3 weeks in ≥ 90% of patients
Secondary Outcome:

•Number of participants with actionable genomic results
•Number of participants with adverse events due to tumour biopsies on study
•Patient and physician experience of this research process and their understanding of genomic analysis including perceptions of benefit versus disadvantages, impact on clinical care and decision making
This is a prospective cohort study with the goal of obtaining fresh tumour biopsies and one blood sample from patients with a confirmed histological or cytological diagnosis of cancer, who are potential candidates for a phase I or II clinical trial at their local institution. DNA from fresh tumour biopsies and from mononuclear blood cells will be subjected to targeted and genome-wide sequencing to enable molecular characterization of tumours. Application of genomic information by investigators will be captured. Archived tumour samples will be requested from all patients. For patients with malignant ascites or pleural effusions, fluid and tumour samples will be evaluated

janie1
Posts: 753
Joined: Apr 2011

It's me (not Pete)....where is Pete?
This study looks interesting. Looks like they only use fresh tumor biopsies so anyone in remission/or no tumor to biopsy couldn't participate.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

thanks smokeyjoe,

this is the genetics of the tumour and its onco genes i think.

the genetics test i did was more looking at diet, lifestyle and supplement interventions about tweaking our detox pathways and keeping our inflamation down.

all awareness of our genetics, or uniqueness means we can truly targetted and focused therapies at our own biologics.

so i may need fish oil and you may not.

i see suspect we are getting a climpse of the tip of the iceberg.

thanks for putting this up here, I know my obsession with my biology and research is over the top. i am amazed it took 13 months after my surgergy to spend the money on the molecular testing.

my argument is that if someone had told me to do it day one, i might have said yes, i might have pursued the targetted natural therapies from day one. granted a bit difficult during chemo, but i would have tried. would i be around today with a cea=0 , hard to say, but one thing is fore sure. discussing the molecular tests, and then the genetic tests, and their are lots of different genetic tests. at least we are discussing these sujbects here, maybe newbies will ask questions. if they learn from our experiences, they may make better decisions that may help them.

hugs,
pete

ps i have been in hiding after my multidisciplenary post. i think its safe to come out!

steved
Posts: 835
Joined: Apr 2004

As Pete says this is a glimpse of the future. Most of us have been through generic chemo regimes of 5FU, oxaliplatin etc which studies show help some people and we all hope we will be one the ones it helps. This type of study is the beginning of developing more targeted treatments for those that carry certain gene types. It does show how foetal the research is though that they are simply looking at the whole genome for patterns and associations. At current levels of understanding really thinking we can use much of our genetic information to guide treatment is little more than guess work (except for cetuximab for KRAS tumours which was more an incidental finding if I understand its history right).

However I would encourage people to participate in this kind of study though (which does include using archived biopsies not just fresh ones) as will benefit future generations (including our children, some of whom unfortunately will carry our wonky cancer genes).

steve

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

My genes analysis fitgenes makes. Diet, exercise and lifestyle recommendation, now many here still claim diet and exercise are not backed by evidence based med.

That is the last nail in the coffin as far as ebm. I need no further proof,
My obsessiond are based on science and commonsence. IMHO.

If you got 90 min watch the lecture from the conference, seems pretty good to me.

Different strokes, different folks.

I have faith in Jesus easy, faith in ebm is hard and believing KFC and macs is good for me, well it would be easier for me talk walk on water.

I just do what gives me peace, that means I also defend my beliefs for me based in science.

Hugs,
Pete

Ps read about omega 3 omega 6 ratio and trans fat and tell that every burger and fries sold is not feeding cancer. Who needs healthy cell membranes anyway? I do, at least, look in the mirror when biting your big MAC and look in your eyes if you have to. If you can enjoy it, knowing about trans fat, sugar and putrification then enjoy. I'd rather have chemo any day then big MAC at least one is anti cancer and one is pro cancer.

Chart cancer rates and growth of fast food. I just think fast death,
and I want to live.

Some say my diet stuff is extreme, I feel like a conservative taking the safest anticancrt approach, anyone one else well sort well I admire your faith in ebm, in chemo and the sad. Sad equal standard American diet.

If you want great health, it takes a little sacrifice and effort.

toyfox's picture
toyfox
Posts: 158
Joined: Apr 2011

I guess some would also think our diet and lifestyle is extreme.
Were eating a raw organic whole plant food diet. Maybe have
organic meat once or twice a month. We avoid all cleaning and personal
care products that contain harmful chemicals.

We know all about trans fat, sugar and and problems with
fast food. Never plan are stepping into another fast food place
again especially after watching the video (earthlings) listed below.
Earthlings, this video show what is done to animals just to
provide us with the cheapest food or cheap clothing.

http://www.youtube.com/watch?v=FHA4HNbmDLg&feature=related
If you care for animals this is heartbreaking to watch.

We are going to do everything possible to stay healthy and take
care of this beautiful earth we have been given.
Linda

smokeyjoe
Posts: 1428
Joined: Feb 2011

I heard a news snippet today that rising obesity rates and contributing to cancer incidences on the rise...70% increase of risk for, (I think they said) kidney cancer.

Buckwirth's picture
Buckwirth
Posts: 1272
Joined: Jun 2010

Increases the risk factor for most cancers, among other things. If you are young, and do not already have cancer, the single best thing you can do for your health is maintain a healthy weight.

The 70% figure is a kind of journalistic scare tactic. As an example, you may have a 1% lifetime risk of developing kidney cancer, and obesity raises that risk to 1.7%. The real risk of 1.7% is not scary, but saying your risk goes up 70% is scary.

I really consider reporting that way to be dishonest. Treat us like adults and give us real numbers, not scaremongering percentages.

clever_user_name
Posts: 8
Joined: Feb 2012

Blake, this is an interesting article about how percentages can be misleading:

http://www.bbc.co.uk/news/magazine-17389938

In this case, the percentage has to do with an extra serving of red meat per day.

- drummond

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

Welcome, good link.

Do you have crc? Or just passing through.
I hope its the later.

Chances are you have family or griendvwith crc, it a dam popular cancer.

I hopevyou are well, regardless.

Hugs,
Pete

Ps introduce yourself in another post, if it suits you.

coloCan
Posts: 1956
Joined: Oct 2009

not smoking, not being overweight and exercising and moving about, not being sedentary for long periods of time. Diet plays a role as does environment and a bit due to hereditary. For CRC prevention, of utmost import is a timely colonoscopy...

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

Well just $fffffff$k

If west life causes, surely anti west life may help cure.

Is that to unscientific, to me it commonsense.

But I am a vegan rabbit who cheats I had eggs today, a piece of ham and pinapple pizza with my kids on the beach tonight. I was lucky the vegan police did not shoot me.

I love your research.

Hugs,
pete

coloCan
Posts: 1956
Joined: Oct 2009

their own supplements as well, like Dr Mercola's site,alot of good diet, anti-GMO info there too.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

american capitalism at its finest, and they are not for profit it think.

at least they hawk in our faces.
they pass the hawk test for me, in that i read the articles keenly and buy very little from them, not their products are bad, they seem to have good quality , its just many speciality supplement companies have better products ie value or bioavailability etc etc.

hugs,
Pete

steved
Posts: 835
Joined: Apr 2004

This site has always been a source of fascinating information from a wide range of perspectives and that is one of its greatest strengths (interesting videos posted above - thank you). We all travel this journey differently and being exposed to different ways to travel it is useful. It is also vital to respect peoples' choices as to how to do it best for themselves considering their own stories and lives.

I strongly believe in a general healthy lifestyles both in preventing and fighting cancer but my own approach is based on moderation as its main principle- all things are fine in moderation and even healthy activities such as exercise can be harmful if taken to extremes.

This journey is also about managing the challenging and at times overwhelming emothions associated with facing cancer and our own mortalities. One possible side effects of sites like this for some is feelings of guilt that they aren't doing EVERYTHING to fight the cancer. There is always someone doing some form of treatment or lifestyle adjustment that you aren't and this can lead peole to feel woried and ashamed that perhaps they could be doing more.

It is always important to be mindful of these things when we post of our own opinions, ideas and choices.

I am enjoying being back at the site though and seeing it thrive with the energy and enthusiasm that always impressed me so much,

steve

)we seemed to have drifted off teff the original thread of research but hey!)

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hi steve,

you have raised in a concise way some of the most vexing issues i face, some of us face, and why i post most of my experimentation on my blog and not here anymore.

where the discussion of genetics takes us, well into the future of cancer treatment and our own treatment and quality of life.

i feel personally my own future, my survival is based on undoing the cancer friendly life i lived that enabled my crc to thrive, on now focusing on my anticancer life. using genetics a key piece of the puzzle.

I am trying to be impartial, and i just wish our cancer treatments and cures were less controversial. like vit c its claimed expensive and dangerous, i have just started making my own at home, second day, so far so good. want to extend the treatment to gsh and tumeric. yes i know about bias everywhere, meanwhile we have decisions to make. i hope we just make the best decisions we can.

so i guess we can all just share peacefully our journey's and offer our learnings.

hugs,
pete

ps april 2004, you have been around a while, welcome back

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