Pete
Also, I think you had mentioned a dendritic cell vaccine trial in Melbourne (?). What do you know about that trial (which Phase is it in ?).
Does that interest you at all? Sounds like there is not much downside to vaccines, just that they won't work on large tumors, I guess just cells circulating around.
I think there are only Phase 1 dendritic trials in the U.S., actually only one that I know of.
Also, I was reading about a dendritic cell vaccine trial in Germany (i think, a Phase2).
Was wondering what you knew and thought, cause I appreciate all your research and sharing. Thank you!
Comments
-
janie its just my head is exploding
hi janie,
still focused on balance of treatments and life.
its a struggle, or a juggle but a joyful problem to have.
my top priority has been to back off internet research and focus on meditation and sleep and exercise and supplements.
so yes i am very very interested dendritic cell vaccine, but have not done anything about it specifically.
the trial in melbourne was for melanoma but the theory applies to all cancers i think.
yes my friend bob, had one made a few years ago from his tumour in germany, and i beleive the technolgy has moved on since his was done.
today i started the serious chelation therapy focus, getting 1000mg glutathione and my 60gram vit c over 3 hours while meditating.
so my focus at the moment is to confirm the extent of heavy metal toxicity ie hg and pb.
i am seeing dr emmunual the top chelation doc in sydney again friday while today i started the above program to go for 3 days a week for 4 weeks.
at the same time i am bumping up my zinc considerable 150mg daily divided break lunch and dinner to get my zinc to the top range of safe, as any chelation therapy can deplete zinc as well. has anyone else had their zinc levels done ?
so i ill try to fix heavy metals, but to do that i have to fix liver, or lets say getting it running as well as i can now that i know i am a chronic undermethylator.
as i understand it focusing on my glutathionation is an essential preparation step as a three of the chelation experts i have consulted with explained.
its possible my heavy metals disabled my immune system, which helped the little cancer get started.
so whats the point of a vaccine, if my immune system is not up to par.
so i firmly beleive that i will give my biology a chance to heal itself, but its step by step. almost everyday offers me a new insight into my health, my biology.
its possible i ate, lived, exposed myself to lots of toxins physical and mental and well they found a t4n1m0 back on 27th may 2010.
today i may have a few trouble crc's cells hanging on for their lives, while i have a very healthy and happy life. those cells are ones hanging on for life, not me, i really feel their days are numbered.
if cancer cells could be stressed, i know mine are, bloody well freaking out. if its not the white bloods cells eating them, its the tcm, k3, vitaminc c , or the chlorine dioxide, avemar, the quercetin, cimetidine, aspirin the iscador, progurt and juicing. i just don't have all day to type the list.
thanks for asking the question, yes i am interested, very in these vaccines and i guess most us here would be as well.
so say if they come up with the vaccine, we can all have a go.
i still think it prudent to be healthy, the means no toxins, no stress, an activated and well functioning immune system. thats my strategy.
thanks sincerely for asking, its helped me articulate why i am feel so positive.
now my onc warned me about FALSE HOPE.
my comeback is simple.
did any olympic athlete go in an event without the beleif in themselves that they can make it. i bet you most of the gold medalists had a dream of gold.
if they can dream of a gold medal, then i can simply dream of health and all that it entails.
my three H's, hope, happiness and health. its possible i may die from this disease but i am going to get immense satisfaction knowing that i have killed millions of crc cells along the way. if your getting chemo, you goto simile and think at least they killed a few of those troublesome cells on the last cycle, its just a shame about the collateral damage to the rest of our body.
I did me first headstand today in yoga, quiet an achievement as i was a yoga virgin only 3 months ago. I did have a helping hand, but it still felt so good. I also got up to 35 pushups yesterday, its along time since i could do that many, at least 50kg ago and probably 30 years.
I appreciate the kind comments, sometimes i feel that i am the only one buying off some of these strange internet sites like lef and iherb and puritans. sometimes i wonder if we
could have an alternative board.
even my alternative doctors described me as i am experimenting on myself, they say what do you want us to do to you today. i said hangon you guys are running the show are you? they looked at each other. i think they felt challenged when i was discussing the benefits of cr and adf and what did they believe. i like when the doctors have to search for answers, at least they are thinking. I also challenged them on the iv vit c mix and why saline and not hypertonic. being an informed patient may make me a pain in the arse, but at least i help them pay the rent.
i better go, this answer is getting long winded, but today was a great day in my war on my crc. i probably felt like i won a small battle today. my wife and kids are asleep and happy and so will i be soon. while i rest, i will hand over to subconsious to rest my brain and heal. did you know while you sleep your immune system is most active, i might dream of crc cells being eaten. i hope so.
I would like to do the vaccine, at some point, even if its as insurance. its just a matter of when and where and i guess much much.
hugs,
Pete
ps i had a profound insight tonight while reading my son to sleep, the greatest gift i can give my kids and wife, besides my long term presence is an awareness of health. so i helped my 6 year old meditate and we discussed how his white blood cells will come and eat his wart while he sleeps. did you know hypnosis can cure warts? the power of our minds, i hope so. so we eat free range egss, organic chickens and have filtered water. we go to start somewhere.1 -
Thank you, Pete. I knowpete43lost_at_sea said:janie its just my head is exploding
hi janie,
still focused on balance of treatments and life.
its a struggle, or a juggle but a joyful problem to have.
my top priority has been to back off internet research and focus on meditation and sleep and exercise and supplements.
so yes i am very very interested dendritic cell vaccine, but have not done anything about it specifically.
the trial in melbourne was for melanoma but the theory applies to all cancers i think.
yes my friend bob, had one made a few years ago from his tumour in germany, and i beleive the technolgy has moved on since his was done.
today i started the serious chelation therapy focus, getting 1000mg glutathione and my 60gram vit c over 3 hours while meditating.
so my focus at the moment is to confirm the extent of heavy metal toxicity ie hg and pb.
i am seeing dr emmunual the top chelation doc in sydney again friday while today i started the above program to go for 3 days a week for 4 weeks.
at the same time i am bumping up my zinc considerable 150mg daily divided break lunch and dinner to get my zinc to the top range of safe, as any chelation therapy can deplete zinc as well. has anyone else had their zinc levels done ?
so i ill try to fix heavy metals, but to do that i have to fix liver, or lets say getting it running as well as i can now that i know i am a chronic undermethylator.
as i understand it focusing on my glutathionation is an essential preparation step as a three of the chelation experts i have consulted with explained.
its possible my heavy metals disabled my immune system, which helped the little cancer get started.
so whats the point of a vaccine, if my immune system is not up to par.
so i firmly beleive that i will give my biology a chance to heal itself, but its step by step. almost everyday offers me a new insight into my health, my biology.
its possible i ate, lived, exposed myself to lots of toxins physical and mental and well they found a t4n1m0 back on 27th may 2010.
today i may have a few trouble crc's cells hanging on for their lives, while i have a very healthy and happy life. those cells are ones hanging on for life, not me, i really feel their days are numbered.
if cancer cells could be stressed, i know mine are, bloody well freaking out. if its not the white bloods cells eating them, its the tcm, k3, vitaminc c , or the chlorine dioxide, avemar, the quercetin, cimetidine, aspirin the iscador, progurt and juicing. i just don't have all day to type the list.
thanks for asking the question, yes i am interested, very in these vaccines and i guess most us here would be as well.
so say if they come up with the vaccine, we can all have a go.
i still think it prudent to be healthy, the means no toxins, no stress, an activated and well functioning immune system. thats my strategy.
thanks sincerely for asking, its helped me articulate why i am feel so positive.
now my onc warned me about FALSE HOPE.
my comeback is simple.
did any olympic athlete go in an event without the beleif in themselves that they can make it. i bet you most of the gold medalists had a dream of gold.
if they can dream of a gold medal, then i can simply dream of health and all that it entails.
my three H's, hope, happiness and health. its possible i may die from this disease but i am going to get immense satisfaction knowing that i have killed millions of crc cells along the way. if your getting chemo, you goto simile and think at least they killed a few of those troublesome cells on the last cycle, its just a shame about the collateral damage to the rest of our body.
I did me first headstand today in yoga, quiet an achievement as i was a yoga virgin only 3 months ago. I did have a helping hand, but it still felt so good. I also got up to 35 pushups yesterday, its along time since i could do that many, at least 50kg ago and probably 30 years.
I appreciate the kind comments, sometimes i feel that i am the only one buying off some of these strange internet sites like lef and iherb and puritans. sometimes i wonder if we
could have an alternative board.
even my alternative doctors described me as i am experimenting on myself, they say what do you want us to do to you today. i said hangon you guys are running the show are you? they looked at each other. i think they felt challenged when i was discussing the benefits of cr and adf and what did they believe. i like when the doctors have to search for answers, at least they are thinking. I also challenged them on the iv vit c mix and why saline and not hypertonic. being an informed patient may make me a pain in the arse, but at least i help them pay the rent.
i better go, this answer is getting long winded, but today was a great day in my war on my crc. i probably felt like i won a small battle today. my wife and kids are asleep and happy and so will i be soon. while i rest, i will hand over to subconsious to rest my brain and heal. did you know while you sleep your immune system is most active, i might dream of crc cells being eaten. i hope so.
I would like to do the vaccine, at some point, even if its as insurance. its just a matter of when and where and i guess much much.
hugs,
Pete
ps i had a profound insight tonight while reading my son to sleep, the greatest gift i can give my kids and wife, besides my long term presence is an awareness of health. so i helped my 6 year old meditate and we discussed how his white blood cells will come and eat his wart while he sleeps. did you know hypnosis can cure warts? the power of our minds, i hope so. so we eat free range egss, organic chickens and have filtered water. we go to start somewhere.
Thank you, Pete. I know you know a lot of people by now through your research. So I thought I would see if you had heard much from anyone about this subject.
I know what you mean about "head exploding". So much information, but what to do. Chemo is at the top of my list of things I hate. So any "new idea" is very, very, much welcomed.
I love your persistence and determination. I do think quality sleep is one of the best things for the body and the immune system.....so that is important along with everything else.
It's weird, for almost 10 years I only slept about 3 hours per night. I never took a sleep-aid. I'm sure the lack of sleep was one of several factors in this cancer diagnosis. After I was diagnosed, the colon resection got most of the cancer out.
From then on, I started sleeping 8 hours a night, no problem......even in spite of the anxiety that hits me first thing each time I wake up by not letting me forget the crappy disease. I would venture to say that my immune system is better than it's been in a long time. I would like to keep it that way before more chemo messes with it.
Well, enough of my rambling.........
Thank you - - AGAIN.0 -
I think the one in my hospital is the only one in advanced Flljanie1 said:Thank you, Pete. I know
Thank you, Pete. I know you know a lot of people by now through your research. So I thought I would see if you had heard much from anyone about this subject.
I know what you mean about "head exploding". So much information, but what to do. Chemo is at the top of my list of things I hate. So any "new idea" is very, very, much welcomed.
I love your persistence and determination. I do think quality sleep is one of the best things for the body and the immune system.....so that is important along with everything else.
It's weird, for almost 10 years I only slept about 3 hours per night. I never took a sleep-aid. I'm sure the lack of sleep was one of several factors in this cancer diagnosis. After I was diagnosed, the colon resection got most of the cancer out.
From then on, I started sleeping 8 hours a night, no problem......even in spite of the anxiety that hits me first thing each time I wake up by not letting me forget the crappy disease. I would venture to say that my immune system is better than it's been in a long time. I would like to keep it that way before more chemo messes with it.
Well, enough of my rambling.........
Thank you - - AGAIN.
Full Text View
Tabular View
No Study Results Posted
Related Studies
Randomized Trial With Dendritic Cells in Patients With Metastatic Colorectal Cancer
This study is currently recruiting participants.
Verified November 2011 by Fundacion Clinic per a la Recerca Biomédica
First Received on August 9, 2011. Last Updated on November 2, 2011 History of Changes
Sponsor: Fundacion Clinic per a la Recerca Biomédica
Information provided by (Responsible Party): Ramon Vilella Puig, Fundacion Clinic per a la Recerca Biomédica
ClinicalTrials.gov Identifier: NCT01413295
Purpose
The different alternatives used since 1996 to treat metastatic colorectal cancer (MCRC) have increased the mean survival of these patients. This outstanding advance is due to the extended indications for resection of hepatic metastases and to the use of new chemotherapeutic drugs (fluoropyrimidine, irinotecan and oxaliplatin) and monoclonal antibodies (bevacizumab, cetuximab and panitumumab). However, none of these treatments is curative and the majority of patients are overwhelmed by the illness. The first line of treatment for MCRC is FOLFOX and the second, irinotecan plus cetuximab for patients with wild type KRAS gene (60%) with a 30% responses, and bevacizumab plus irinotecan with a 5-10% of responses, in patients with mutated KRAS (40%). A treatment with autologous dendritic cells (DCs) pulsed with autologous tumour antigens is proposed as a third line of therapy. A randomized phase II trial would be performed, by selecting two groups of patients, one of them would be treated with the best supportive treatment and the other with DCs plus the best supportive treatment. The aim of the study would be to analyze the outcome after 4 months of treatment. In patients treated with DCs, IFN-γ spot forming cells and proliferative responses would be determined pre and post treatment in lymphocytes stimulated with autologous DCs pulsed with autologous tumour antigens. Pre and post treatment serum levels of IFN-γ, TNF-α, TGF-β e IL-12, would also be measured.
Condition Intervention Phase
Colorectal Neoplasms
Drug: Dendritic Cell Vaccine
Other: Supportive treatment
Phase II
Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Phase II Trial in Patients With Progressive Stage IV Colorectal Cancer to Two Lines of Chemotherapy, in Order to Compare the Best Supportive Treatment Versus Treatment With Dendritic Cells Plus the Best Supportive Treatment
Resource links provided by NLM:
MedlinePlus related topics: Cancer Colorectal Cancer
U.S. FDA Resources
Further study details as provided by Fundacion Clinic per a la Recerca Biomédica:
Primary Outcome Measures:
Progression Free Survival [ Time Frame: 4 months ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
Overall Survival [ Time Frame: 4 months ] [ Designated as safety issue: No ]
Estimated Enrollment: 76
Study Start Date: August 2011
Estimated Study Completion Date: August 2014
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Dendritic Cells Vaccine
Dendritic Cells Vaccine after 2 lines of chemotherapy
Drug: Dendritic Cell Vaccine
Vaccination with autologous dendritic cells loaded with autologous tumor antigens
Supportive treatment
Supportive treatment after 2 lines of chemotherapy
Other: Supportive treatment
Supportive treatment after progression of the illness after 2 lines of chemotherapy
Eligibility
Ages Eligible for Study: 18 Years and older
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria:
Age over 18 years.
Capacity of understanding and signing the informed consent and to undergo the study procedures.
Previously treated with 2 lines of chemotherapy.
ECOG <= 2.
Adequate renal, hepatic and bone marrow function
Confirmed diagnosis of colorectal cancer with hepatic metastasis, suitable for biopsy.
Availability of tumor tissue, for maturing dendritic cells
RECIST.1 criteria
Exclusion Criteria:
Clinically relevant diseases or infections (HBV, HCV, HIV).
Pregnant or breast feeding women.
Immunosuppressant treatment.
Concurrent cancer, with the exceptions allowed by the principal investigator (PI).
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01413295
Locations
Spain
Hospital Clínic Barcelona Recruiting
Barcelona, Spain, 08036
Contact: Ramon Vilella, PhD rvilella@clinic.ub.es
Sub-Investigator: Jordi Milà, Biology
Sub-Investigator: Miguel Caballero, M.D.
Sub-Investigator: Antoni Castells, M.D. PhD
Sub-Investigator: Joan Maurel, M.D. PhD
Sub-Investigator: Miriam Cuatrecasas, M.D. PhD
Sub-Investigator: Antonio Maria De Lacy, M.D. PhD
Sub-Investigator: Ramon Vilana, M.D. PhD
Sub-Investigator: Xabier Adrián García, M.D. PhD
Sub-Investigator: Mario Pagés, M.D.
Sub-Investigator: Luis Bianchi, M.D. PhD
Sub-Investigator: Miguel Lozano, M.D. PhD
Sub-Investigator: Pedro José Marín, M.D. PhD
Sponsors and Collaborators
Fundacion Clinic per a la Recerca Biomédica
Investigators
Principal Investigator: Ramon Vilella, PhD Fundació Clinic Recerca Biomédica
More Information
No publications provided
Responsible Party: Ramon Vilella Puig, Senior consultant, Fundacion Clinic per a la Recerca Biomédica
ClinicalTrials.gov Identifier: NCT01413295 History of Changes
Other Study ID Numbers: MCBRVP, 2009-017247-33, TRA-082
Study First Received: August 9, 2011
Last Updated: November 2, 2011
Health Authority: Spain: Agencia Española de Medicamentos y Productos Sanitarios
Keywords provided by Fundacion Clinic per a la Recerca Biomédica:
Colorectal Neoplasms
Dendritic Cells
Additional relevant MeSH terms:
Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
ClinicalTrials.gov processed this record on February 13, 20120 -
thanks pepepepebcn said:I think the one in my hospital is the only one in advanced Fll
Full Text View
Tabular View
No Study Results Posted
Related Studies
Randomized Trial With Dendritic Cells in Patients With Metastatic Colorectal Cancer
This study is currently recruiting participants.
Verified November 2011 by Fundacion Clinic per a la Recerca Biomédica
First Received on August 9, 2011. Last Updated on November 2, 2011 History of Changes
Sponsor: Fundacion Clinic per a la Recerca Biomédica
Information provided by (Responsible Party): Ramon Vilella Puig, Fundacion Clinic per a la Recerca Biomédica
ClinicalTrials.gov Identifier: NCT01413295
Purpose
The different alternatives used since 1996 to treat metastatic colorectal cancer (MCRC) have increased the mean survival of these patients. This outstanding advance is due to the extended indications for resection of hepatic metastases and to the use of new chemotherapeutic drugs (fluoropyrimidine, irinotecan and oxaliplatin) and monoclonal antibodies (bevacizumab, cetuximab and panitumumab). However, none of these treatments is curative and the majority of patients are overwhelmed by the illness. The first line of treatment for MCRC is FOLFOX and the second, irinotecan plus cetuximab for patients with wild type KRAS gene (60%) with a 30% responses, and bevacizumab plus irinotecan with a 5-10% of responses, in patients with mutated KRAS (40%). A treatment with autologous dendritic cells (DCs) pulsed with autologous tumour antigens is proposed as a third line of therapy. A randomized phase II trial would be performed, by selecting two groups of patients, one of them would be treated with the best supportive treatment and the other with DCs plus the best supportive treatment. The aim of the study would be to analyze the outcome after 4 months of treatment. In patients treated with DCs, IFN-γ spot forming cells and proliferative responses would be determined pre and post treatment in lymphocytes stimulated with autologous DCs pulsed with autologous tumour antigens. Pre and post treatment serum levels of IFN-γ, TNF-α, TGF-β e IL-12, would also be measured.
Condition Intervention Phase
Colorectal Neoplasms
Drug: Dendritic Cell Vaccine
Other: Supportive treatment
Phase II
Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Randomized Phase II Trial in Patients With Progressive Stage IV Colorectal Cancer to Two Lines of Chemotherapy, in Order to Compare the Best Supportive Treatment Versus Treatment With Dendritic Cells Plus the Best Supportive Treatment
Resource links provided by NLM:
MedlinePlus related topics: Cancer Colorectal Cancer
U.S. FDA Resources
Further study details as provided by Fundacion Clinic per a la Recerca Biomédica:
Primary Outcome Measures:
Progression Free Survival [ Time Frame: 4 months ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
Overall Survival [ Time Frame: 4 months ] [ Designated as safety issue: No ]
Estimated Enrollment: 76
Study Start Date: August 2011
Estimated Study Completion Date: August 2014
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Dendritic Cells Vaccine
Dendritic Cells Vaccine after 2 lines of chemotherapy
Drug: Dendritic Cell Vaccine
Vaccination with autologous dendritic cells loaded with autologous tumor antigens
Supportive treatment
Supportive treatment after 2 lines of chemotherapy
Other: Supportive treatment
Supportive treatment after progression of the illness after 2 lines of chemotherapy
Eligibility
Ages Eligible for Study: 18 Years and older
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria:
Age over 18 years.
Capacity of understanding and signing the informed consent and to undergo the study procedures.
Previously treated with 2 lines of chemotherapy.
ECOG <= 2.
Adequate renal, hepatic and bone marrow function
Confirmed diagnosis of colorectal cancer with hepatic metastasis, suitable for biopsy.
Availability of tumor tissue, for maturing dendritic cells
RECIST.1 criteria
Exclusion Criteria:
Clinically relevant diseases or infections (HBV, HCV, HIV).
Pregnant or breast feeding women.
Immunosuppressant treatment.
Concurrent cancer, with the exceptions allowed by the principal investigator (PI).
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01413295
Locations
Spain
Hospital Clínic Barcelona Recruiting
Barcelona, Spain, 08036
Contact: Ramon Vilella, PhD rvilella@clinic.ub.es
Sub-Investigator: Jordi Milà, Biology
Sub-Investigator: Miguel Caballero, M.D.
Sub-Investigator: Antoni Castells, M.D. PhD
Sub-Investigator: Joan Maurel, M.D. PhD
Sub-Investigator: Miriam Cuatrecasas, M.D. PhD
Sub-Investigator: Antonio Maria De Lacy, M.D. PhD
Sub-Investigator: Ramon Vilana, M.D. PhD
Sub-Investigator: Xabier Adrián García, M.D. PhD
Sub-Investigator: Mario Pagés, M.D.
Sub-Investigator: Luis Bianchi, M.D. PhD
Sub-Investigator: Miguel Lozano, M.D. PhD
Sub-Investigator: Pedro José Marín, M.D. PhD
Sponsors and Collaborators
Fundacion Clinic per a la Recerca Biomédica
Investigators
Principal Investigator: Ramon Vilella, PhD Fundació Clinic Recerca Biomédica
More Information
No publications provided
Responsible Party: Ramon Vilella Puig, Senior consultant, Fundacion Clinic per a la Recerca Biomédica
ClinicalTrials.gov Identifier: NCT01413295 History of Changes
Other Study ID Numbers: MCBRVP, 2009-017247-33, TRA-082
Study First Received: August 9, 2011
Last Updated: November 2, 2011
Health Authority: Spain: Agencia Española de Medicamentos y Productos Sanitarios
Keywords provided by Fundacion Clinic per a la Recerca Biomédica:
Colorectal Neoplasms
Dendritic Cells
Additional relevant MeSH terms:
Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
ClinicalTrials.gov processed this record on February 13, 2012</p>
Amazing.
I hope the trial works.
Hugs
Pete0
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