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Stage 2 UPSC - What is the outlook?

Posts: 2
Joined: Aug 2011

My wife was diagnosed last summer with UPSC with clear cell features. She has had a full hysterectomy, including the ovaries, Fallopian tubes, etc. on Aug. 31. At that time she was told that she is Stage 2A. She is nearing the completion of 6 rounds of carboplatin / taxol chemo. The next step is radiation. We have not yet met with the radiation oncologist.

Two questions here:
1. What sort of radiation therapy is generally given for this type and stage of cancer? How often? How long is each session? How many sessions? How bad are the side effects?
2. What is the outlook for survival?

Posts: 275
Joined: Jun 2011

Bill, like all of us here, your wife is a statistic of one (I am quoting someone else). Any statistics on survival are old and outdated for this rare kind of cancer.

Many of us had pelvic radiation for about a month (daily sessions) followed by 3-5 sessions of internal brachytherapy.

My daily radiation sessions lasted for 10 minutes. The brachytherapy sessions were 7 minutes each (spaced about 3 days apart) but the prep time for each one was about 20 minutes. A couple of weeks prior to starting brachytherapy, I had a simulation session in which all the measurements were done. It was pretty invasive.

My side effects from the pelvic radiation were nausea, exhaustion, bowel "issues", and more exhaustion. Some people have no side effects. I always say that there has never been a side effect - of anything - that I did not have!

Double Whammy's picture
Double Whammy
Posts: 2805
Joined: Jun 2010

Just want to add that I have a dear friend who had Stage 2 UPSC FIVE years ago. She had chemo and radiation. No recurrence. None. Nada. NED.

Good luck to your wife. And yes, she is a statistic of one.


Posts: 52
Joined: Nov 2011

I wonder why some drs. recommend chemo and radiation and others just radiation? From doing some research I am going with chemo and radiation. My radiation dr. was fine with that. I am having 4 chemo and 3 internal radiation. From what I have read Stage 1 and 2 are 80% survival rate; at least I hope so. Stay positive and don't let anyone or anything get you down.

Posts: 2
Joined: Aug 2011

As I understand it, Grade 1 (non-aggressive) Uterine Cancer is usually treated with just radiation if it is stage 1 or 2. But UPSC is a Grade 3 (aggressive) cancer. My wife's gyn/onc says that he treats aggressive cancers aggressively, so that is why both. UPSC is the same type of cancer as is the most common form of Ovarian cancer. The carbo/taxol chemo regimen is what is usually used for Ovarian, and it seems to be pretty standard for UPSC as well.

Posts: 296
Joined: Nov 2008

Hi Bill,

I am a Stage IIA UPSC survivor. I was diagnosed in Oct. 2008. I had four rounds of carbo/taxol and sandwiched in between I had three rounds of brachy therapy. I was scheduled for 6 rounds of chemo but did not tolerate it well and the Oncol and I decided four rounds would be enough.

She should only be getting brachy therapy (vaginal cuff) since the cancer did not spread outside of the uterus. If she is only getting the brachy, it's a breeze. Only thing is it is embarrassing and you feel a little violated, but it doesnt't hurt.

Keep the faith, don't read the stats, tell her to eat raw ginger; great stuff for inflammation and upset stomach.



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