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Stage IV uterine cancer

2capecodkids
Posts: 1
Joined: Oct 2011

Hello, I was wondering if anyone has been treated w/avastin for stage iv uterine cancer and how it worked for you? I was diagnosed w/stage iv uterine cancer in 4/10 at age 48 with mets to bone, lungs and lymph nodes. I've been on taxol/carbo., doxil, megase and then taxol alone. I've recently developed a toxicity to my lungs from the taxol and my medical oncologist at Dana Farber wants me to try avastin. She said it isn't FDA approved for uterine cancer yet, but that she knows of other women who went on it for uterine cancer and had great success. I was wondering if anyone out there has tried that. Thank you!

snowbird_11's picture
snowbird_11
Posts: 160
Joined: Oct 2011

I was also Stage IV @ diagnosis. I have not been treated with Avastin - my current gyn-onc is not a fan of it but I have found he prefers old standbys to anything new. There have been a few posters who have been treated with Avastin but in conjunction with chemotherapyand then continue on with Avastin as maintenance. You are being treated at one of best cancer treatment facilities here in US. I hope this works for you. Please let us know how you tolerate it and how effective it is.
Wishing you success.
Annie

Lori_VA
Posts: 16
Joined: May 2011

I was in a clinical trial at NIH for Avastin and dasatinib. It didn't work for me, but it worked for almost everyone else. The trial had a variety of cancers, not just uterine. Everyone is different and there are several types of uterine cancer. The only side effect I had was that the dasatinib caused my hemoglogin to drop.

california_artist's picture
california_artist
Posts: 865
Joined: Jan 2009

This is a report on taxol and comination with turmeric that showed positive results particularly for those who were having difficulty with taxol's toxicity. Sincerely hope this helps. Please copy the trial to save it other than just here.

Taxol and turmeric benefits in long term Taxol use. Lessens Taxol's toxicity.

They are talking about taxol and breast cancer, but they are talking about taxol, which I do believe can initially be very effective in treating non pap serous endo cancers.Then they go on to discuss -TaXOL USED OVER TIME: They say: Because Taxol is so toxic, it activates a protein that produces an inflammatory response that induces metastasis.But and here's the good news-talking about curcumin(an ingredient in easily obtainable turmeric): researchers found that the nontoxic natural substance not only repelled progression of the disease to the lungs, but also appeared to reverse the effects of paclitaxel (Taxol TM ), a commonly prescribed chemotherapy for breast cancer that may trigger spread of the disease with use over a long period of time. It mentions that curcumin lessens the toxicity of taxol by specifically breaking the dose into more manageable size, thus giving cancer less of a target to respond to negatively.Article further states: In fact, researchers found that adding curcumin to Taxol actually enhances its effects.and this:Curcumin breaks down the dose, making the therapy less toxic and just as powerful while delivering the same level of efficacy.I had read this before in regard to the combo.Honestly, what's not to love about this news.So, all in all, I read this as very good news potentially. I am sure that other universities will be picking up on this and adding their research findings either in support or not. But basically it could potentially help those with recurrences have a far better response to Taxol.Anyone wishing further information contact the original researchers or M.D.Anderson directly for current status, it is not my study, I'm just putting it out there.

TRULY HOPE SOME OF YOU BRING THE INFO TO THE ATTENTION OF YOUR DOCTORS. BEST WISHES TO YOU

The Study reported on by ScienceDaily

Early Study Shows Spice Stunts Deadly Spread To Lungs

ScienceDaily

(Oct. 16, 2005) — HOUSTON - Curcumin, the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer Center. [My comments: I do think this is worth reading. Talks of turmerics beneficial use in conjunction with Taxol. the spaces in the article were put there by me so it would be easier to see why you might be interested, everything else in the same. I thought I had posted this but didn't see it anywhere. Might be something to bring to the attention of your doctors.]--------------------------------------------------------------------------------The study, to be published in the Oct. 15 issue of the journal Clinical Cancer Research, reports that the spice appears to shut down a protein active in the spread of breast cancer to a major target for metastasis.Though the study results are early, researchers found that the nontoxic natural substance not only repelled progression of the disease to the lungs, but also appeared to reverse the effects of paclitaxel (Taxol TM ), a commonly prescribed chemotherapy for breast cancer that may trigger spread of the disease with use over a long period of time. Because Taxol is so toxic, it activates a protein that produces an inflammatory response that induces metastasis. Curcumin suppresses this response, making it impossible for the cancer to spread.In fact, researchers found that adding curcumin to Taxol actually enhances its effect.Curcumin breaks down the dose, making the therapy less toxic and just as powerful while delivering the same level of efficacy."We are excited about the results of the study and the possible implications for taking the findings into the clinic in the next several years," says Bharat Aggarwal, Ph.D., professor of cancer medicine in M. D. Anderson's Department of Experimental Therapeutics. "At this time, advanced breast cancer is a difficult foe to fight with few proven treatments available after surgery, chemotherapy and radiation therapy."Taxol is currently used as the front-line chemotherapeutic agent in breast cancers, but because the drug frequently induces drug resistance after prolonged use, it is not effective in treating metastatic breast cancer, says Aggarwal.Researchers studied 60 mice with breast cancer, which were randomly assigned to one of four groups: control group, Taxol only, curcumin only and the combination of Taxol and curcumin. After the tumors grew to 10 mm (about the size of a pea), they were surgically removed, and the mice were fed a powdered curcumin diet.Macroscopic lung metastasis, or metastasis that is visible to the naked eye, was seen in 96 percent of the mice in the control group. Treatment using Taxol alone only "modestly reduced" the incidence of metastases, while the group using curcumin alone and curcumin plus Taxol "significantly reduced" both the incidence and numbers of visible lung metastases. Microscopic metastasis, or metastasis that is visible only when using a microscope, was found in the lungs of 28 percent of mice treated with the combination of curcumin and Taxol, and there was no macroscopic disease present. The micrometastases present consisted of only a few cells, suggesting that the combination inhibited the growth of breast cancer tumor cells that were in the lung before the tumors were removed. In a previous study published in the Aug. 15 issue of the journal Cancer, M. D. Anderson researchers found that when the nuclear factor-kappa B (NF-kB) (a powerful protein known to promote the inflammatory response necessary to cause breast cancer to spread) is shut down, cancer strains are unable to grow and cells are pushed to commit suicide. The mechanism in this curcumin study works the same way. Taxol activated the NF-kB in breast cancer cells, while curcumin stopped this activation by blocking the protein known as "IKK" that switched on the NF-kB, demonstrating how curcumin and Taxol work against one another. Taxol produced the inflammatory response, triggering metastasis, and curcumin suppressed it, causing cell death. Extracted from the roots of the curcuma longa plant, curcumin is a member of the ginger family. While it is not used in conventional medicine, it is widely prescribed in Indian medicine as a potent remedy for liver disorders, rheumatism, diabetic wounds, runny nose, cough and sinusitis. Traditional Chinese medicine uses curcumin as a treatment for diseases associated with abdominal pain, and it is used in ancient Hindu medicine as a treatment for sprains and swelling. According to the American Cancer Society, the chance of a woman having invasive breast cancer sometime during her life is one in eight. About 211,240 women in the United States will be diagnosed with invasive breast cancer in 2005, and approximately 40,410 women will die from the disease this year.###The study was funded by the United States Department of Defense. Co-authors include Shishir Shishodia, Ph.D.; Yasunari Takada, Ph.D.; Sanjeev Banerjee, Ph.D.; Robert A. Newman, Ph.D.; Carlos Bueso-Ramos, M.D., Ph.D.; and Janet E. Price, Ph.D.

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