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"Harvard Scientists Discover How Cancer Outwits Erbitux Drug"

coloCan
Posts: 1956
Joined: Oct 2009

as reported at: bloomberg.com/news/2011-09-07/scientists-discover-how-cancer-outwits-erbitux.html

(and a potential solution)

Buckwirth's picture
Buckwirth
Posts: 1271
Joined: Jun 2010

Harvard Scientists Discover How Cancer Outwits Erbitux Drug

As usual.

BTW, see Phil's most recent thread...

Blake

laurettas
Posts: 372
Joined: May 2011

I hereby bestow the clickable link award to Blake!!

Now on the the article--what wonderful news!! Trials in six months possibly---Yahooooo!!!!

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PhillieG
Posts: 4911
Joined: May 2005

Krysta Pellegrino, a spokeswoman for Roche, said that while the company wasn’t familiar with the research, it thinks that “the hypothesis is scientifically sound.”

Thanks Steve...

Buckwirth's picture
Buckwirth
Posts: 1271
Joined: Jun 2010

Roche did not fund this!

I am shocked!

:smile:

tanstaafl's picture
tanstaafl
Posts: 1295
Joined: Oct 2010

"suggest...Herceptin from Roche Holding AG (ROG) might be combined with Erbitux to surmount resistance."
No doubt awaiting combined toxicity data, if not insurance approvals.


Cancer-Growth Genes.... generated lung cancer cells in the test tube that were able to evade the effects of Erbitux by making additional copies of a growth- boosting gene called ERBB2, or HER2."

Erbitux blocks overexpression of ErbB1 (aka EGFR, Endothial Growth Factor Receptor, alias HER1). These researchers are proposing to additionally block Erb2 to make Erbitux treatment effective.

While they search for a viable monoclonal antibody recipe, we try to modulate any HER2 (ErbB2) overexpression with things like quercetin and menaquinone-4, as described in the literature. One of cimetidine's biological actions is interfering with the cellular growth signals from ErbB1 (aka EGFR), as well as reducing VEGF-A (partly as Avastin does) for those with tumor sourced CA19-9 (and CSLEX1), like the large majority of advanced CRC patients have.

Cumulatively, my wife has taken cimetidine now for almost 18 months, quercitin for 17 months and menaquinone-4 (a vitamin K2) for about 14 months. We actually got lab data that showed her cimetidine soaked (pre-surgery doses, 800 mg each) tumor cells croaked best when additionally treated with 5FU, ascorbate and menaquinone-4 as chemotherapy, whatever the molecular biology.

smokeyjoe
Posts: 1428
Joined: Feb 2011

Okay Buck, you amaze me!!! When I put my little arrow thingy to your link I get the line "someday Steve will figure out how to do this".....how did you do that!!!

coloCan
Posts: 1956
Joined: Oct 2009

now i get what you mean......Three points for you.....steve

(one of these days i'll figure it out)

Buckwirth's picture
Buckwirth
Posts: 1271
Joined: Jun 2010

:smile:

smokeyjoe
Posts: 1428
Joined: Feb 2011

Search Pubmed, apparently there is some effect on cocoa on this.....sounds too good to be true but apparently it downregulates expression of this, in test tube samples anyway.

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