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Femara/Letrozole - "Real" vs Generic?

Posts: 3659
Joined: Aug 2009

Just wondering if those who were on Femara and have gone to the generic have noticed any differences in them?

I had just gotten my 3 mth supply in just before the Generic came out so I'm still on the 'Real' Femara until late Aug but I recently got my next 3 months worth in and it's the Generic.

So has anyone noticed any differences.


lanie940's picture
Posts: 492
Joined: Jul 2009

I am on the generic Arimidex and I haven't noticed any difference.

Posts: 598
Joined: Sep 2009

I had the same question and asked my onco. He said the main ingredient is the same. So switched over. Good luck. Maybe ask ur onco. I'd be interested in his/her answer. Katz

mollyz's picture
Posts: 753
Joined: Sep 2010

I think the price of it is all they pretty much have the same ingredients.I'm on 2.5mg of letrozole and i pay only $7.oo (that's co-pay after Ins.)

skipper54's picture
Posts: 936
Joined: Feb 2011

from my experience. I had the "real" stuff for 2 or 3 months and now the generice for about the same length of time. Color is different and price but I get it all for the same $ anyway.

Posts: 3659
Joined: Aug 2009

My generic ones look exactly like the real Femara - same size and color just have different marking on them. The new ones have E126 on them and the Femara has FV on one side and GG on the other. The generic that I have are made by Qualitest.

The generic cost me the same as the real did. Doesn't matter what the med is, I pay $8 per month for each script I have. Don't know why they do it but VA sends some in 3 month lots and some monthly.


Posts: 51
Joined: Sep 2010

Pharamacy Education and says there seems to be no difference. The FDA has rules about the producing generic drugs and any difference would have to be reported. Although the FDA has messed up before.

I am also on Femera and seem a little stiffer than before. Bt its so hot here that I don't walk like I used to. I have been on the generic since it came out because my insurance won't pay for a 90 day supply.

Posts: 1
Joined: Nov 2012

I've been taking Letrozole since the breast cancer was discovered in my lung - that has been 10 years this year. Two types of chemo failed to knock it out and as I was preparing for radiation, I started taking Letrozole. Within a month the tumor began to shrink and all that is left is scarring where it once was. I am so grateful to my doctor for recommending it to me. My other oncologist didn't even mention it. Needless to say I'm happy to be alive and enjoying life.

jerseygirl231's picture
Posts: 178
Joined: Mar 2011

Not the brand name I had no sleep for a year and a half terrible joint pain terrible back pain falling for no reason two very bad falls terrible weight gain I wish you the best. I am back on the brand name enjoying sleep weight been stable joint and back pain has not been that bad

Posts: 2
Joined: Feb 2015

I have only been on Letrozol for a month but noticing the joint pain, particularly in my hands.  Lots more aches and pains - feel like i am 90 but am only 57.  Read lots of recent blogs that point toward femara being almost side-effect free.  Would love to know if it is worth fighting for it.  The prospects of 5 - 10 years like this, or worse - is scary!  Sally

Posts: 3659
Joined: Aug 2009

It's been 3 1/2+ yrs since I started this thread and I'm still on letrozole and will be on it 'forever'.  I've had from different manufacturers with no negative issues.

Winyan - The Power Within



Jazzbear's picture
Posts: 8
Joined: Dec 2012

I have been on Letrozole for just over two years.  I have never been on Femerol.  The initial side effect of Letrozole for me was joint pain in my shoulders and fingers.  That lasted about three months.  Then that disappeared and pain started in my hips.  I sleep on my side so each morning, between 3 - 4 a.m., I wake up with pain and have to shift from side-to-side every 20 - 30 minutes.  The other discouraging side effect is that my hair is thinning.  My oncologist confirmed that is definitely a Letrozole side effect. 

mamamoody's picture
Posts: 28
Joined: Jun 2015

I've been on Femara (letrozole) for about a year.  I have  "late stage 3 Recurrent Uterine Cancer to the Lungs".  After having a hyster, chemo, and radiation for treatment ...I found out the cancer had spread to my lungs.  I then had more chemo, which really cut down the number and size of the small nodules peppered throughout both lungs. Afterwards, my gyn/onc & onc said no more chemo, I had reached my max.  They suggested the Femara, since my cancer is estrogen based.  The good news...the med has reduced the number and size of nodules ...I am down to one small nodule in each lung and I've had no new nodules anywhere.  The bad news .. general pain, bad joint pain, bad sleep,a fuzzy face, and general tiredness.  Some days are worse than others.  It doesn't help that I'm 59, morbidly obese, diabetic, and already had knee and hip problems.  I've tried the other two estrogen inhibitors, but came back to the letrozole ...the others were even worse for me.  Some days are worse than others and I have been given Tramadol and Lortabs to help with the pain when needed.  Overall, on most days I can pretty much function normally with help from the pain meds.  I get a one week vacation off the letrozole every 12 weeks.  Yea! Love that week and it really gives me a mental boost.  May God bless you

Posts: 10
Joined: Jul 2015

I started off with brand with minor bone, limb, muscle pain, dizzy, confusion.  Generic ended up in wheelchair and pain meds could not fix it.  had to chose between quality and quanity of life and stopped taking drug and issues went away.  Doctor gave me name brand and again fine.  Got access to name brand 6 months.  Now 6 days back on generic and close to wheelchair again and many other bad issues.  So generic not even close to name brand and I tried all the manufactor of the generic.  There is a difference, so those that it impacts - it is NOT your imagination.  We even tried blind dosing me and my body reacted badly to the generic, and no, I did not know which I was given and they look the same.

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