Folfox X 2

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damama24
damama24 Member Posts: 174 Member
in Colorectal Cancer #1
I am wondering if anyone out there has done Folfox multiple times? When first dx'd I did folfox and avastin. I made it only six rounds when the neuropathy and fatique got so bad that onc dropped the oxi(it was reduced on round 4 but the neuropathy didn't improve.) I stayed on the rest of the folfox combo for 7 more rounds. CEA started to rise and scan showed progression.
I then went on iriontecan and vectibix.I was on this for 26 rounds. At about round 22 my CEA started to climb after having dropped steadily.Onc tweaked the chemo and ordered a scan to check if cancer was progressing. Scan was mixed some tumors showed shrink but one showed a slight increase. Did 4 more rounds and did another scan, CEA still going up at this time.Second scan showed progression of mets in liver.Since I had good response to folfox the first time( just really bad neuropathy and fatique) onc wanted to try it again. I have the second round of folfox and avastin wednesday. I guess I'm just really worried about the neuropathy being permanent this time. I do get a cal-mag infusion both before and after the oxi. I'm hoping it helps. I also have been told by a 3rd surgeon that I'm inoperable. I was hoping after 2 years of chemo things would change. I don't know how long I'll make it on the folfox this time, hopefully more than 6 rounds. I guess I'm a little concerned, can't stay on the oxi for ever and after that....I'm just not sure where we will go from there.
Deb

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  • johnnybegood
    johnnybegood Member Posts: 1,117 Member
    #2
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    hello
    i was on folfox from march-july 2009.i did 10 treatments and onc decided i had enough good thing because i felt like i had one foot in the grave.now i have had a recurrance was dx jan.2011 with mets to liver and lung.my surgen wanted me back on folfox +avastn i said i would try but i have permenant neuropathy in my hands and feet and i am dissabled to the point where i cant do factory work anymore.that is all i have done for over 20 years.sooo we tried it.after the first infusion which by the way was a low dosage my fingers were so bad they felt like they had been smashed with a hammer.so i was taken off of folfox and put on iriatecan+avastin.i have had 4 treatments and my scans show my tumors are shrinking.there is no way i could have taken the oxy again because my chemo onc said it just would damage me more to where i would be more disabled then i already am.be careful with that folfox if you have permenant neuropathy like i do it will only make it worse....Godbless...johnnybegood
  • luvmum
    luvmum Member Posts: 457 Member
    #3
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    Dear Deb
    I hope your body can cope with this round of FOLFOX well and will respond to it well too.

    Best wishes,
    Dora
  • pete43lost_at_sea
    pete43lost_at_sea Member Posts: 3,900 Member
    #4
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    goodluck deb
    maybe look at my post on folfox good news re glutamine, i think it really helps. askyour onc.
    hugs,
    pete

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