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Double Whammy's picture
Double Whammy
Posts: 2835
Joined: Jun 2010

Diane and Annie and anyone else:

Do you believe your cancer was a side effect of Tamoxifen? Were your docs doing routine ultrasounds to check the lining of your uterus?

Since I got both breast and endometrial cancers at the same time, it certainly didn't play a role in my case. I have also been told by those white coated people that it is not unusual for a woman to have both cancers over the course of her lifetime because the risk factors are the same. Since I frequent both the breast and uterine cancer boards, I've seen it both ways - breast first or uterine first.

Just curious.


upsofloating's picture
Posts: 473
Joined: Dec 2009

My doctors all deny that there is any relationship between tamoxifen and my UPSC. I disagree. After year one on tamoxifen, my oncologist informed me annual endo biopsies were no longer considered necessary while on tamoxifen. My first ultrasound was after I developed a sudden onset of quite significant bleeding. A D&C indicated no cancer but many! Polyps were found. I changed to femara but I had been on tamxifen 6.5 yrs. at the recommendation of my med onc. Later when I got copies of my med record, she stated continued treatment w/tamoxifen was at my request! (Cya!) No primary was found at debulking surgery 2 yrs later - thought to have been 'missed' in D&C and was in one of polyps removed - all rather vague. Unfortunately, whatever the situation, I can't go back and change it. I would definitely rec regular monitoring to anyone on tamoxifen.

Posts: 350
Joined: Feb 2004

Online information from the National Cancer Institute on endometrial cancer prevention, found at
http://www.cancer.gov/cancertopics/pdq/prevention/endometrial/HealthProfessional/page2, states in part as follows:

"Based on solid evidence, more than 2 years of tamoxifen use is associated with an increased risk of endometrial cancer.[16,17] A different selective estrogen receptor modifier, raloxifene, does not have this association.[18,19]

Magnitude of Effect: Women taking tamoxifen for more than 2 years have a 2.3-fold to 7.5-fold relative risk (RR) of endometrial cancer.

Study Design: Multiple randomized controlled trials.
Internal Validity: Good.
Consistency: Good.
External Validity: Good."

See the above link for the entire article, including cited studies.


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