CSN Login
Members Online: 8

You are here

clinical trial adomet (SAMe) helps heal folfocked liver damage UPDATE not phase 3 study

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hope for all new folfoxers

sorry but folfox can really damage your liver, in case your onc failed to advice you.

see the study, this is from 2003 and a more recent from 2011 why am i the only digging up the relevant trials that can save our butts. our survival is supposed to be a team effort.
posted this on colonclub as well. not in either of our archives.

here we go again.................

i am still smiling in my picture.

2011 study folfoxiv
http://www.ncbi.nlm.nih.gov/pubmed/21406026

2003 study
http://www.ncbi.nlm.nih.gov/pubmed/14981985

Abstract
BACKGROUND: Liver toxicity can be observed during treatment with most chemotherapic agents, and represents one of the principal causes of dose reduction or chemotherapy delays. S-Adenosylmethionine (AdoMet) plays a critical role in the synthesis of polyamines and provides cysteine for the production of glutathione (GSH), the major endogenous hepatoprotective agent. Our study was aimed at assessing the protective effect of AdoMet supplementation in cancer chemotherapy-induced liver toxicity.

PATIENTS AND METHODS: Fifty cancer patients who developed, for the first time, anticancer chemotherapy-induced liver toxicity were studied. Enrolled patients received oral AdoMet supplementation.

RESULTS: AST, ALT and LDH levels recorded at the moment of the recognition of liver toxicity were significantly reduced after one week of AdoMet therapy (respectively p: 0.009, 0.0005 and 0.012). AST, ALT and LDH decrease was confirmed after two weeks of treatment. Furthermore, the effect on these enzyme levels persisted in the following chemotherapy courses, permitting our patients to perform the scheduled chemotherapy courses with a minimal number of dose reductions or administration delays. The efficacy of AdoMet supplementation was not influenced by the presence of liver metastases, and no appreciable side-effects were recognized.

CONCLUSION: The results of our study clearly demonstrate a protective effect of AdoMet in cancer chemotherapy-induced liver toxicity. Further large phase III studies are required to assess the real clinical benefit associated with AdoMet supplementation

UPDATE discussed SAMe adoment with naturopath 1 thersa, it may stimulate the liver detox which may prematurely get folfox out of your earlier, which may reduce its effectivess. this is just a comment that needs to be included. also changed the title from fixes to helps heal, which is more accurate.

Livingbyfaith's picture
Livingbyfaith
Posts: 56
Joined: Sep 2007

We love this product, its a mood enhancer, never knew this information. Thanks.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

i am happy now as well despite the dramas.
this product has been around for years, the trials since dam 2003.

everyone suffered more folfox liver damage needlessly, ignorance kills

why don't the onc care ?

guess what after the new study, i bet this will be standard protocol 5 years after big clinical studies.

how much suffering in the mean time and stress.

this is the news that really saves lives.

gee we would not need to support each nearly half as much if our treatmeants were not
so shiitty, an once of prevention hey ??

thanks for the feedback and reading.

a common food supplement thats proven to help us while fighting cancer on folfox.
not one good comment. guess all heads are in the sand.
besides yours, speaks volumes about the awareness and appreciation here for this type
of research. its why its never been found before.

glad your on it,

i am glad i am on it now at least.

wish some on this board new about this earlier, wish my onc mentioned it!
wish i knew about it earlier!

never mind no use crying over spilt milk.

some said oh wait a year and your bloods will pickup

i say why not wait a week and take SAMe

hugs,

pete

lisa42's picture
lisa42
Posts: 3661
Joined: Jul 2008

Interesting about Sam-e... prior to going on antidepressants, my kids and hubby were all taking Sam-e (I think the 400 mg tabs) & it really did help my son and youngest daughter, but older daughter and husband didn't notice much improvement. It was really helping the two kids though for about a year until they needed something a bit heavier duty. I had taken Sam-e myself for awhile but have forgotten about it lately. Maybe I should start up on it again- there really are no known side effects from it and I could use a mood booster much of the time lately. If it will also help the liver, well then it's an added bonus! Interestingly, when I first mentioned to the psychiatrist my daughters were going to that they had been on Sam-e, he said he never heard of it. That seems pretty stupid and out of it to me- can't believe he was that locked into only knowing about pharmacy drugs and nothing else.
Sam-e is a naturally occuring chemical in the brain & there are many things that can cause a depletion of it, contributing to depression and mood swings.
Interesting new things learned all the time, huh?!

Lisa

Anonymous user (not verified)

This comment has been removed by the Moderator

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hi gracie,

even the board dramas don't get me down. samE mood upper , liver fixer. colorectal wonder food.

its very expensive, anyone found a good value internet supplier.
for me about $200 per month based 4 caps per day. don't plan to be on this long term.

its just what i need. it may help others, but please check with your dietician not your doctor as its a food supplement.

is this amazing or what?
hugs,
pete

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

i made this post separate as its specific to folfox,but maybe also applies other chemos!

sets an interesting precident in my opinion.

if we all begged and insisted that onc do more to mitagate side effects.

my diarrhea battle another example.

its so ironic that you were on samE for it mind benefits not its liver, but it was doing both anyway, so you have tested it already, how are your liver numbers ??

would love some anecdotal results. lucky this is just a food!!!!hehehehe

hugs,
pete

ps note for advice sandra cabot liver guru
dear sandra,
i am winning my battle with bowel cancer based on your liver and bowel book, i have followed your program to the letter. thanks. now i have finished 6 months folfoxchemo.
i am taking 17mg milk thistle and samE x 4 200mg
my ast alt ggt are all double and triple upper bounds and my platlettes crashed to 115.
any conflict milk this and samE

will post answer.
thanks heaps,
pete

smokeyjoe
Posts: 1428
Joined: Feb 2011

Any thoughts on the use of liquid chlorophyll? Anyone taking this??

lisa42's picture
lisa42
Posts: 3661
Joined: Jul 2008

Yup- have some liquid clorophyl. I do believe it makes a difference for the good in my red blood cell counts. I don't take it all the time because I ingest lots of greens as it is, but I give it a squirt (it comes in a bottle with a dropper) in a beverage a couple of days in a row when I feel the most tired and when my counts usually are the lowest after chemo & I believe it helps. Chlorphyl makes oxygen and that helps make more red blood cells and oxygenating our cells is a good thing too!

Lisa

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hi lisa,

another day, yippee!!!

I guess I am getting some natural chlorhyl when I juice my broccoli and beans with beets and carrot and celery. etc etc. been adding the spirullina as well, and biopectin into the morning juice, just lazy and throwing it all into together.

limes are on special now here, been adding a lime in as well, they taste good.

tastes like crap, so it must be good for me!!!!

I'll read about it, sounds ineresting and good links ?

I just hope you feel great everyday with energy and passion.

hugs,
pete

SisterSledge's picture
SisterSledge
Posts: 342
Joined: Feb 2011

Can't help it...makes me chuckle every time :)

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

thanks janine

i cannot find my teat list, 1000's unsorted emails, will keep on trying.

hugs,
pete

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

http://altmedicine.about.com/od/treatmentsfromatod/a/SAMe.htm

I have found a few sources on the net heaps cheaper than what i just spent.

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

I wonder if SAMe helps,
is this to co-incidental.
It could be my recently revamped juicing program.
it could be neither, I am just so glad my fingers feel normal, well about 98%.

My feet also feel almost normal, at least some improvments, rather than the nerve damage getting worse.

Anonymous user (not verified)

This comment has been removed by the Moderator

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hi gracie,

I am clearly seeing the benefits of our great forum.

If onc don't tell us, at least we can share.

We will simply be the most informed colorectal patients on the planet.

Imagine if the onc start browsing this forum to start learning some tricks.

Any onc with enough character to admit they read our posts. but stop I am dreaming....

I hope your having a wonderful day,

Pete

westie66's picture
westie66
Posts: 642
Joined: Jun 2010

Hi: I'm from the gallbladder cancer discussion group. Although I had my gallbladder, its tumour, and part of my liver removed last April (2010), and then did a round of chemotherapy using cisplatin and gemiticibine (Gemzar) here in Canada, what needs to go now are 6 peritoneum nodules (cancerous). My oncologist views this kind of like colon cancer. I am not eligible for the peritoneum removal surgery nor for the intraperitoneal chemo (only one place does it in Canada and they haven't had any success with gallbladder cancer patients), but my oncologist is going to try the dreaded oxaliplatin/irenotecan/5FU etc. chemotherapy done both through an IV every 2 weeks and a 46 hr infusion. My question is this: how much SAM-e does one take to help with neuropathy? I purchased a bottle of 100 mg SAM-e today. On the label it says take 3 tablets 3 times a day and that SAM-e was good for fibromyelga (which in many ways is similar to neuropathy in my mind). But someone above mentioned you take 4 tablets a day (but the number of mg was not given). I did not have a problem with neuropathy with the cisplatin/gemitibine mix (none at all actually) but I think oxaliplatin is much more of a 'beast'! I start chemo May 17. Someone on the gallbladder discussion group took L-glutonate to help with the neuropathy. Any ideas on this?
Thanks!
Cheryl

lisa42's picture
lisa42
Posts: 3661
Joined: Jul 2008

About purchasing Sam-e, I have found it to be cheapest online through Swanson Vitamins- you might also check amazon.com and see what you can get it for there. It's about 2/3 the price, sometimes even half the price of what you can get it for in the stores.
I use the 400 mg. pill- goes farther and you don't have to swallow as many pills.
As I said above, I had been purchasing it for kids with depression & definitely found it to be a mood booster. Never new about the other benefits of it until reading these postings here. I took it for a while for myself, but stopped & I have now just started back up on it after reading all this.

One note on the Sam-e, I read awhile back that it's best to take in the morning, as it could possibly interfere with sleep if taken in the evening.

Has anyone out there heard of 5-HTP? It is also a mood enhancer. I take one before bed each night lately. It is best to be taken before bed and not in the morning, as it tends to calm you down and could possibly make you sleepy. I take it because I have discovered from experience it helps with feelings of stress and/or anger better than Sam-e did for me. I wonder if it might also have some added benefits with the cancer, just like the Sam-e apparently does.

Lisa

smokeyjoe
Posts: 1428
Joined: Feb 2011

I googled 5-HTP and liver toxicity....google it...there are some warnings.

lisa42's picture
lisa42
Posts: 3661
Joined: Jul 2008

Ooh- okay- I better read up on it- thanks for the heads-up!

westie66's picture
westie66
Posts: 642
Joined: Jun 2010

Hi Lisa: Thanks! my bottle says take on an empty stomach so that would be the morning for me! before breakfast! So, how many of the 400 mg pills do you take per day? One? The bottle I bought cost $36 for 60 pills so I'll surely look for a cheaper source! Thanks for the tips.
Cheryl

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

Thanks for visiting the colorectal world here, sorry you had the need too.

The SAMe study posted initially was just for liver damage. Only liver damage and folfox.

That said SAMe is an interesting product with lots of infomation on the net available.
Its not been publicially discussed on these forums before so I raised it for discussion purposes.

Now its called co-incidence, so the fact my neuropathy improved while on is very likely that. Please just read the studies if your interested, and discuss with your doctor and support team.

The studies are not stage 3 clinical, not double blind studies with a large sample. I draw your attention to these caveats.

I wish you only the very very best of health and luck in your treatment.
cheers,
Pete

westie66's picture
westie66
Posts: 642
Joined: Jun 2010

Hi: Thanks, Pete. I will do that. At this point I want to try anything so I don't get that neuropathy thing! It doesn't sound good to me. I didn't have any problems with cisplatin but oxaliplatin seems a different beast. And the irenotecan! Good luck tomorrow.
Cheryl

smokeyjoe
Posts: 1428
Joined: Feb 2011

Westie66, Cheryl, where in Canada are you?? I'm in Ontario.

Kenny H.'s picture
Kenny H.
Posts: 503
Joined: Aug 2010

Thanks for the info Pete.
Currently taking the milk thistle, will look into finding some adament. What dosage do you take?
Having some nuerapthy issues myself. Hands and feet really numb (drop things & hard to do some tasks. Button shirt ect) hope it helps this to but mainly need to get my liver count back down.

After 12 rounds of poison ended I thought things would get easier. Guess with time it will I pray.
Onc never mentioned none of these to help either. =-(

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

if i could swear on this board i would, i so hate to hear about survivors nasty side effects, i even read my own posts and feel sorry for pete. i am sorry to hear about dropping things. it makes me sick to my stomach that we have made it through folfox and are left with these sides, did you get cal/mag infusions ? not that it matters now really, damage been done, just curious. now the study to minimise the peripheral neuropathy been out for a while, still people get what i was dished up with.

we have the power to insist about the very best care in the most passionate way, for us we can insist to onc about sides. the issue is some of the remedies are natural and the doctors want have a bar of them, no trials, no adaquate proof to offset mitagation risk, so we just sit, sleep, walk and blooody well suffer. i have certainly been desparate enough to try most alt things with some science backing.

if all our onc's cared like say lenz, maybe we would be better off. like his advice milk thistle or b complex for 5fu many maybe better off.

just get the best caring and professional advice you can re your sides. if they are as important to you

i started to get worried when yes the penis started to get a bitnumb, ten i really started researching. mind you made sex last alot longer. hey, every dark cloud has a silver linning.

i have noticed my balance maybe an issue, if my eyes are open i am ok. if i put a towel get dry the few remaing hairs well i almost topple over like a bag of shiiit. i have heard of some here having balance issues.

sorry to rave,

its not the dex its the morphine,

I forgot how good it is,

hugs,
pete

westie66's picture
westie66
Posts: 642
Joined: Jun 2010

Hi Smokeyjoe: I am in London, Ontario. Where are you?
Cheryl

smokeyjoe
Posts: 1428
Joined: Feb 2011

South end of Lake Simcoe..... north of Toronto. Maglets is from Ont. too... Nice to meet you!!! P.s. Smokeyjoe is my kitties name in the photo. I see you have a cute little Westie. Take care Leena.

westie66's picture
westie66
Posts: 642
Joined: Jun 2010

HI again: Not too far away! Where do you get your treatments - in Toronto? Did you have the oxiliplatin/irentocen/5FU treatment? If so, how did it go for you? I think with colon cancer (stage III) the oxiliplatin costs are covered but not for me. Where is "Maglets" from in Ontario? Yes, Charlotte is a cutie and my joy.
Cheryl

pete43lost_at_sea's picture
pete43lost_at_sea
Posts: 3908
Joined: Nov 2010

hi all interested adoment, samE

I am glad i am using this post chemo.

consider this comment from my naturopath

UPDATE discussed SAMe adoment with naturopath 1 thersa, it may stimulate the liver detox which may prematurely get folfox out of your earlier, which may reduce its effectivess. this is just a comment that needs to be included. also changed the title from fixes to helps heal, which is more accurate.

hugs,

pete

Subscribe to Comments for "clinical trial adomet (SAMe) helps heal folfocked liver damage UPDATE not phase 3 study"