Clinical trial for resistant cases

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LaundryQueen
LaundryQueen Member Posts: 676
in Ovarian Cancer #1
Here is a link to a Phase I clinical trial at MD Anderson. It includes Torisel which has been shown to benefit women diagnosed with clear cell OVCA.

http://clinicaltrials.gov/ct2/show/NCT01187199
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Avastin/Torisel With Carboplatin, Taxol, or Sorafenib

Official Title ICMJE Phase I Trial of Bevacizumab and Temsirolimus in Combination With 1) Carboplatin, 2) Paclitaxel, 3) Sorafenib for the Treatment of Advanced Cancer
Brief Summary The goal of this clinical research study is to find the highest tolerable dose of the combination of bevacizumab (Avastin) and temsirolimus (Torisel) that can be given with 1 of 3 other study drugs --carboplatin (Paraplatin), paclitaxel (Taxol), or sorafenib (Nexavar). The safety of these drug combinations will also be studied.

Detailed Description The Study Drugs:

Bevacizumab is designed to prevent or slow down the growth of cancer cells by blocking the growth of blood vessels.

Temsirolimus is designed to block the growth of cancer cells, which may eventually cause the cancer cells to die.

Carboplatin is designed to damage the DNA (the genetic material of cells)of cancer cells, which may will eventually cause the cancer cells to die.

Paclitaxel is designed to damage the DNA of cancer cells, which may eventually cause the cancer cells to die.

Sorafenib is designed to block the function of important proteins in cancer cells. These proteins, when active, are in part responsible for the abnormal growth and behavior of cancer cells.

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  • Rookerbird
    Rookerbird Member Posts: 100
    #2
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    Avastin/Torisel Trial
    Thank you, LaundryQueen. How do you have time to research all this stuff? Awesome!!!

    I've been admitted to the MDA system, and the clinical trial door is open to me. Will read about this study in full tomorrow. So many considerations...

    - The oncologist I saw at MDA suggested we hold off on clinical trials until I've tried Doxil, Taxotere, Topotecan.
    - There are a multitude of reasons why I want to stay in Dallas for treatment.
    - I'm allergic to Carboplatin so if the arms are randomized, I'm not sure I would be eligible.
    - Phase I trials are scary! I'd rather die from the disease in a "predictable" way than die from a side effect from a trial.

    But, someone has to do the trials in order for research to progress. Has anyone on this board been in a Phase I trial?

    -Kathy
  • LaundryQueen
    LaundryQueen Member Posts: 676
    #3
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    Rookerbird said:

    Avastin/Torisel Trial
    Thank you, LaundryQueen. How do you have time to research all this stuff? Awesome!!!

    I've been admitted to the MDA system, and the clinical trial door is open to me. Will read about this study in full tomorrow. So many considerations...

    - The oncologist I saw at MDA suggested we hold off on clinical trials until I've tried Doxil, Taxotere, Topotecan.
    - There are a multitude of reasons why I want to stay in Dallas for treatment.
    - I'm allergic to Carboplatin so if the arms are randomized, I'm not sure I would be eligible.
    - Phase I trials are scary! I'd rather die from the disease in a "predictable" way than die from a side effect from a trial.

    But, someone has to do the trials in order for research to progress. Has anyone on this board been in a Phase I trial?

    -Kathy

    Phase I trial
    Kathy: I don't know if the arms of this trial are randomized--somehow I got the impression that they are not. Although this is a Phase I trial, none of the chemotherapeutic agents are experimental--only the dose is experimental. The dose will be adjusted if side effects are problematic.

    Once the "therapeutic dose" as been found for the various combinations, more subjects will be enrolled in the trial to be treated with the therapeutic dose combination. You might think about waiting until there is more certainty as it is so important that your mind feels secure with your therapy. However, I don't know when the enrollment will end.

    I find this trial so exciting as it is testing the effects of various agents in combination. This research is not just for OVCA but for various chemoresistant conditions.

    From everything I have ingested and digested about the problem of chemo resistance, I believe the answer is in combination therapy. Perhaps your oncologist will consider combination therapy for your future chemo.

    I wouldn't enroll in a trial because "someone has to be the guinea pig," but only because I truly felt that I trusted that I was on the right path for me.

    You asked how I have time to look for such information. Insomnia! I tried to go back to work last week and was totally wiped out and was on the couch all day yesterday (Saturday) and then I was up late at night.

    I recently met a fellow survivor who has not been in remission since her diagnosis two years ago and has been on 9 different chemos and is still working to keep her CA-125 down. The condition she is gonna defeat is clear cell OVCA--and I was looking for any information that might incude Torisel (targeted-therapy for clear cell kidney cancer) as someone posted somewhere that they were doing very well on Torisel for ovarian clear cell.

    Her gyn/onc is willing to use Torisel and I am hoping that he puts it together with taxol/taxotere. She hasn't tried the "dose dense taxol" yet only taxol every 4 weeks.

    Please feel free to mark my posting as "inappropriate" if the research does not apply to this discussion board. I was up late at night when I posted the info on the clinical trial.

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