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IP Clinical Trial NCI

paris11
Posts: 160
Joined: Oct 2010

If interested, you can google this. I am starting 5 of 6 Cycles of IV paclitaxel weekly and IP carboplatin for a 2nd recurrence of Stage IV endometrial cancer. The chemo treatment has been refined and is not that difficult. I think that close to 90% of women complete the 6 Cycles.

February 9, 2010 • Volume 7 / Number 3 | About the Bulletin| Archive/Search

Optimizing Chemotherapy with Bevacizumab for Ovarian Cancer

Name of the Trial
Phase III Randomized Study of Bevacizumab in Combination with Intravenous Versus Intraperitoneal Chemotherapy in Patients with Stage II, III, or IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Carcinoma (GOG-0252). See the protocol summary.

Dr. Joan Walker
Principal Investigator
Dr. Joan Walker, Gynecologic Oncology Group

Why This Trial Is Important
Women with ovarian cancer usually undergo surgery to determine the cancer’s stage and to remove as much malignant tissue as possible. Following surgery, these women are treated with chemotherapy in an effort to eliminate remaining cancer cells.

Typically, chemotherapy for ovarian cancer is administered intravenously (IV) and travels throughout the body in the blood (systemic chemotherapy). Research by the Gynecologic Oncology Group and others, however, has demonstrated that combining IV chemotherapy with the delivery of chemotherapy drugs directly into the peritoneal cavity (intraperitoneal, or IP, chemotherapy) is more effective in delaying cancer progression and helping patients live longer. Since tumors are often confined to the peritoneal cavity in patients with ovarian cancer (as well as in those with fallopian tube or primary peritoneal cancer, which are biologically similar diseases), IP chemotherapy may allow for a greater concentration of anticancer drugs in the area around the tumors while limiting side effects elsewhere in the body. Results published in 2006 from a phase III trial showing a median increase in survival of 12 months for women treated with IV plus IP chemotherapy led NCI to issue a clinical announcement encouraging use of the combined treatment.

Other recent developments in the treatment of ovarian cancer may offer benefits similar to those seen with IV plus IP chemotherapy while avoiding some of problems associated with it (such as increased toxicity and difficulty of administration). A recent phase III study using the chemotherapy drug paclitaxel intravenously on a weekly basis, along with IV carboplatin given every 3 weeks, yielded improvements in progression-free and overall survival compared with the same drugs given every 3 weeks. Additionally, treatment with the angiogenesis inhibitor bevacizumab has shown significant antitumor activity in phase II studies.

In this trial, patients with stage II, stage III, or stage IV ovarian epithelial, fallopian tube, or primary peritoneal cancer will be randomly assigned to receive one of three chemotherapy regimens:

IV paclitaxel weekly and IV carboplatin every 3 weeks
IV paclitaxel weekly and IP carboplatin
IV paclitaxel and IP cisplatin, followed by IP paclitaxel
All patients will receive IV bevacizumab during and following chemotherapy. Doctors want to know which of these three regimens is most effective in delaying progression and improving survival.

“This trial is designed to determine if IP therapy is still superior given the clinical advances seen with regimens using weekly IV paclitaxel and/or bevacizumab,” said Dr. Walker. “The added benefit of weekly IV paclitaxel and bevacizumab, in combination, for women with ovarian cancer has the potential to be a very exciting advance.”

For More Information
See the lists of entry criteria and trial contact information or call the NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). The toll-free call is confidential.

Ro10's picture
Ro10
Posts: 1579
Joined: Jan 2009

Very interesting. For those who do not know what drug bevacizumab is it is Avastin. (I had to look it up. Thought I would save you a "google") Other sisters have talked about treatment with Avastin. I know some siters have gotten the weekly taxol with carbo every 3 weeks. I know most of us did the taxol/carbo every three weeks. It will be interesting to see what others in the near future will be treated with.

Of course this trial was for ovarian. We know UPSC is very much like ovarian, so it will be interesting.

paris11
Posts: 160
Joined: Oct 2010

I think most uterine cancers are treated like ovarian

For my IP/IV Chemo treatment I have Day 1 IV taxol IP carboplatin, Day 8 IV taxol, Day 15 IV taxol. No breaks - just repeat the 21 days.

Today I had Cycle 5: Day 1 IV taxol IP carboplation. No side effects. CT Scan last Thursday shows the enlargement in the aortic lymph node has dissolved.

We will continue and complete Cycle 5 and 6. I was stunned when the oncologist offered IV/IP. I was diagnosed in Feb. 2007.

Just another option for our arsenal.

Best love to all the Warriors,

Connie

Ro10's picture
Ro10
Posts: 1579
Joined: Jan 2009

Finished cycle 5 already. It seems to have gone fast, but probably not to you. I am glad you continue to do well. The fact that the enlargement of the aortic lymph node has dissolved is wonderful news. I am so glad this treatment has been successful for you. You truly are a Warrior. In peace and caring.

Always Hopeful
Posts: 234
Joined: May 2010

What great news, Connie...the enlargement dissolved!

What exactly gets done in IP therapy? I understand there is an abdominal port but what I'm not sure about is how the chemo actually "touches" the tumors/growths. Do you have to reposition your body often?

Enjoy your good news!

Peace and hope, JJ

maggie_wilson's picture
maggie_wilson
Posts: 616
Joined: Nov 2009

i'm so glad to hear that that aortic lymph node enlargement has dissolved;--may it ever be so! that's such good news. and great that you are tolerating the treatment so well. thank you, connie, for being such a diligent reporter; i certainly feel stronger knowing that ip/iv can possibly be in my arsenal if needed, along with the avastin. what would we all do without each other??

sisterhood,
maggie

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