Mental Aspect of Cancer Patients

My husband was diagnosed in April of 2009 with stage 4. metastic pancreatic cancer. Currently going thru phase two of Chemo, 1st was Gemzar and Tarceva, which seemed to in the beginning have remarkable results...however we are now on 5fu with leukavorin and Oxyplatin, (sorry about the spelling) Just having real memory difficulty and dealing with alot of Anger. Paranoia is prevalent, and even the rx's don't seem to help...has anyone dealt with this stage of this horrible disease.