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ct results

alta29's picture
alta29
Posts: 435
Joined: Mar 2005

Not what I needed.....all tumors are still there, some are stable some have grown ( Dr. not concerned cause they only grew 1-3 mm) but there are 2 new ones. So we are changing cocktails..we are going from Erbitux & CPT 11 to Folfox Plus . That cocktail ( without Avastin) kept me in remission fro a year...so now we are having the same one plus avastin. I cried....but I am ready for it again..I am doing Scouty's diet to the T starting today and I am going to start the Vit. C infusion.....God bless u all...

rmap59
Posts: 266
Joined: Jun 2007

hi,
God Bless You too. I am sorry for your news but you are a fighter and will win this battle with your attitude. You are in my prayers.
Love, Robin

KathiM's picture
KathiM
Posts: 8077
Joined: Aug 2005

I am sending my biggest, strongest healing hugs dearheart..ENOUGH is ENOUGH!!!!!! Go AWAY beast, GO AWAY!!!!

Please keep us posted, sweet soul!

Hugs, Kathi

sladich's picture
sladich
Posts: 430
Joined: May 2007

A positive attitude! Best of luck with your treatments and keep us posted. Happy Holidays.

Debbie

valeriec's picture
valeriec
Posts: 350
Joined: Oct 2006

I'm sorry the results were not what you wanted them to be, but your attitude is so awesome that I'm sure the Folfox with Avastin is going to do the trick. Praying that the treatments are tolerable, and that the next scan has you in remission again. Good luck to you and Merry Christmas.
God bless-
ValerieC

hopefulone
Posts: 1048
Joined: Jan 2007

Alta, I know how difficult it is to get disappointing news , but the avastin has a good possibility of turning the tide back your way. So a big hug, my best thoughts and wishes and prayers. Keep the faith .God Bless
Diane

Faith4Cure
Posts: 405
Joined: Mar 2007

Sorry you didn't get the news that you needed. You have a good attitude and will be ready to fight again. Stay positive and keep on believing. My prayers are with you.

Faith

jenalynet's picture
jenalynet
Posts: 363
Joined: Nov 2005

Though your news is not what you wanted to hear, your attitude is amazing..Keep fighting this rotten disease , I will be thinking of you,sending warm hugs, Audrey.

pink05
Posts: 553
Joined: Mar 2006

I know that this is not what you wanted to hear, but what I admire most about you is that you get right back up and fight. You have a great attitude. I'm glad you are doing Lisa's diet. Let us know how it goes. As always, keeping you in my prayers.

-Lee-

betina61's picture
betina61
Posts: 644
Joined: Aug 2006

I'm so sorry too,but you are a fighter,and probably this next cocktail is the one that will bring you back to meet with Ned again.Keep the faith. Sending you hugs and prayers.

jerseysue's picture
jerseysue
Posts: 626
Joined: Oct 2005

Best of luck and keep up the great attitude.

Felixthecat
Posts: 37
Joined: Dec 2007

You could try this one. The drug referred to below is only available via the FMFs Compassionate Use Program so if other treatments are unsuccessful you could contact them and try it. It is a hormone antagonist and quite well tolerated as meds go:

Their website link is:
http://feminist.org/rrights/compassionateuse.asp

2004: Effects of mifepristone on proliferation of human gastric adenocarcinoma cell line SGC-7901 in vitro.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15309708&itool=iconfft&query_hl=20&itool=pubmed_docsum
Mifepristone effectively inhibited the proliferation of PR-positive human gastric adenocarcinoma cell line SGC-7901 in vitro through multiple mechanisms, and may be a beneficial agent against human adenocarcinoma

2004: (Detailed article) Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone
http://www.thymic.org/thypdf/biol/mif2.pdf

2004: Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone
http://www.wjgnet.com/1007-9327/abstract_en.asp?v=10&f=1722
Mifepristone has potent reversal effect on MDR in SGC7901/VCR via inhibiting the function of MRP and P-gp, modulating the expression of Bcl-2 and Bax proteins, and enhancing the sensitivity to anticancer agent VCR

2004: Inhibitory effects of mifepristone on the growth of human gastric cancer cell line MKN-45 in vitro and in vivo.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15669177&itool=iconabstr&query_hl=20&itool=pubmed_docsum
Mifepristone exerts significant growth inhibitory effects on PR-positive human MKN-45 gastric cancer cells via multiple mechanisms, and may be a beneficial agent against the tumor.

2004: Effects of mifepristone on invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15188494&dopt=
• “Mifepristone can effectively inhibit the invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivo through inhibition of heterotypic adhesion to basement membrane, cell migration and angiogenesis.”

2003: Glucocorticoid Cotreatment Induces Apoptosis Resistance toward Cancer Therapy in Carcinomas1
http://cancerres.aacrjournals.org/cgi/content/full/63/12/3112

GCs are widely used in high doses in the therapy of leukemias and lymphomas and are also used as antiemetics or preservatives for normal cells during chemotherapy of solid tumors. In addition, GCs are among the most widely used anti-inflammatory drugs. In this study, we have shown that application of GCs renders certain tumors resistant or less susceptible to apoptosis after cancer therapy. This finding urges to carefully reconsider the widespread use of GCs in almost all treatment protocols for patients with solid cancers. In the clinical setting of cancer therapy, e.g., in antiemetic regimens, corticosteroids are usually given transiently to suppress acute side effects of cancer therapy. Although our experiments did not mimic precisely the clinical situation because we administered DEX daily to achieve steady-state levels, short-term exposure to DEX may nevertheless be sufficient to abrogate or diminish the efficacy of concomitant chemotherapy in cancer patients in vivo. This is suggested by our experiments where DEX was found to down-regulate basal and cisplatin-induced expression of apoptosis effectors within 24 h in vitro. Also, endogenous levels of GCs and those existing as a consequence of administered hormones may render solid tumors less susceptible to apoptosis after cancer therapy. The administration of steroid/receptor agonists such as RU486 might be beneficial before chemotherapy and radiotherapy to enhance cell death of solid tumor cells

2006:Therapy of cancer by cytokines mediated by gene therapy approach.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16474432&dopt=Abstract
Gene therapy offers a new approach for treatment of cancer. Transfer of genes encoding immunostimulatory cytokines has been used with remarkable success to eliminate cancer in animals. However, clinical trials in patients with this strategy had limited efficacy. Therefore, improvement of gene transfer vector system is necessary. A hybrid viral vector, consisting of SFV replicon with either murine IL-12 or reporter LacZ gene, was constructed. This hybrid vector showed specificity and high level of expression in HCC both in vitro and in vivo. In a rat orthotropic liver tumor model, treatment of established tumors by the hybrid vector with mIL-12 gene resulted in a strong anti-tumor activity without accompanying toxicity. Subsequently, a helper-dependent adenovirus vectors containing a mifepristone (RU486) inducible system was constructed for controlled and liver-specific expression of human interleukin 12 (hIL-12) (HD-Ad/RUhIL-12) and mouse IL-12 (mIL-12) (HD-Ad/RUmIL-12). Data showed that high and sustained serum levels of hIL-12 could be attained by continuing administration of RU486 every 12 or 24 h. Repetitive induction of hIL-12 could be obtained over, at least, a period of 48 weeks after a single injection of HD-Ad/RUhIL-12. Treatment of liver metastases with of HD-Ad/RUmIL-12 plus RU846 resulted in complete tumor regression in all animals. Then, different cytokine genes were inserted into conditional replicative adenoviruses vectors (also called oncolytic adenovirus). Replication of adenovirus in tumor cells would kill tumor cells and release viruses, which infect surrounding tumor cells. The combination of cytopathic effect by oncolytic adenovirus and biological effect of transgene would exert strong antitumor activity. These new types of vectors may provide a potent and safe tool for cancer gene therapy.

KierstenRx's picture
KierstenRx
Posts: 249
Joined: Nov 2006

I'm sorry to hear about your results. I am sending you all the positive vibes I can. I'll keep you in my prayers.

Kiersten

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