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First bite question

Sunriver's picture
Posts: 50
Joined: Sep 2006

After my second chemo infusion I had a significant increase in "first bite" pain. This is not a cold sensitivity just pain with the first few chews of anything. Several people here said they had the same thing. My question is which of the FOLFOX drugs is this a side effect of? Thanks in advance...Mark

Posts: 553
Joined: Mar 2006

Hi Mark,

My father also had the same problem and always complained of that. His onc said that it was due to the oxaliplatin. He complained of that side effect less and less as he continued to receive the chemo. The onc recommended a calcium supplement to help ease the pain. My dad never tried that, so I don't know whether or not it works. I'm sure others will have some more suggestions. Hope this helps.


Posts: 425
Joined: Jan 2005

My husband is on oxaliplatin and xeloda and we have been told it is the oxaliplatin that causes it..

Monicaemilia's picture
Posts: 455
Joined: Nov 2006

I was on Oxaliplatin and had the same reaction. It did go away after the 6th or 7th cycle.

KathiM's picture
Posts: 8077
Joined: Aug 2005

I hate to admit to this, but I can't remember. One of the few GIFTS of chemo brain...

I am sending big, healthy vibes your way...

Hugs, Kathi

jerseysue's picture
Posts: 626
Joined: Oct 2005

Last year I thought it was because of the oxaliplatin but I'm taking chemo again and not using oxaliplatin and I still get the "first bite" pain. So I'm taking all the FOLFOX minus the oxaliplatin. Interesting....

nudgie's picture
Posts: 1482
Joined: Sep 2006

I finished 6 of 12 FLOFOX treatments and two of the chemo drugs, 5FU and Oxy both can cause this problem. I had it after the 3rd treatment I think until I finished on 3 November.

Posts: 59
Joined: Mar 2006

It is a documented side effect of the oxalaplatin. I completed my chemo over a year and a half ago and I sometimes randomly still get the first bite bite.

vinny3's picture
Posts: 933
Joined: Jun 2006

I had it for the first 6 cycles but then it seemed to disappear. I found that biting down or clenching my teeth just before eating something helped to lessen it.


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